2023
Stimulation of the Pro-Resolving Receptor Fpr2 Reverses Inflammatory Microglial Activity by Suppressing NFκB Activity2022
Development of chitosan, pullulan, and alginate based drug-loaded nano-emulsions as a potential malignant melanoma delivery platform2022
Exploiting formyl peptide receptor 2 to promote microglial resolution: a new approach to Alzheimer's disease treatment.2021
Regulation of TNF-Induced Osteoclast Differentiation.2020
Reversal of beta-Amyloid-Induced Microglial Toxicity In Vitro by Activation of Fpr2/32020
Novel anti-inflammatory and chondroprotective effects of the human melanocortin MC1 receptor agonist BMS-470539 dihydrochloride and human melanocortin MC3 receptor agonist PG-990 on lipopolysaccharide activated chondrocytes2018
Extracellular vesicles and their nucleic acids for biomarker discovery2016
Activation of melanocortin receptors MC1 and MC5 attenuates retinal damage in experimental diabetic retinopathy2015
Both MC1 and MC3 Receptors Provide Protection From Cerebral Ischemia-Reperfusion-Induced Neutrophil Recruitment.2014
Melanocortin peptides protect chondrocytes from mechanically induced cartilage injury2013
Urocortin protects chondrocytes from NO-induced apoptosis: a future therapy for osteoarthritis?2012
Chondroprotective and anti-inflammatory role of melanocortin peptides in TNF-α activated human C-20/A4 chondrocytes2012
The central role of myostatin in skeletal muscle and whole body homeostasis2009
Melanocortin peptide therapy for the treatment of arthritic pathologies2009
Melanocortin peptides modulate pro-inflammatory mediator release from TNF-a stimulated C-20/A4 cells2018
Effect of Urocortin on human osteoclasts differentiation2018
Quin-C1: a selective Fpr2 agonist that shifts microglial phenotype following LPS and Aβ1-42 exposure2017
Reversal of β-amyloid induced microglial activation by an agonist of Fpr22017
The effect of silymarin on chondrocytes2017
Fpr2 and neuroinflammation: selective agonists with synergistic anti-oxidative and pro-resolving effects2017
The effect of the selective MC3 agonist PG990 on high density human chondrocytes micromass cultures activated by TNF-alpha2017
Activation of the pro-resolving receptor Fpr2 attenuates inflammatory microglial activation2017
The effect of the selective human MC3 receptor agonist PG992 on high density human chondrocyte micromass cultures activated by IL-1beta.2015
The effect of melanocortin peptides on Interleukin 1-beta induced chondrocyte cell death and inflammation2015
Acute hypoxia reduces plasma myostatin independent of hypoxic dose2015
The effect of melanocortin peptides on Interleukin 1-beta induced chondrocyte cell death and inflammation2014
The melanocortin receptor antagonist SHU9119 inhibits the anti-inflammatory/pro-resolving properties of a-MSH and D[TRP8]-y-MSH in lipopolysaccharide stimulated chondrocytes2014
The role of acute hypoxia in skeletal muscle atrophy2013
Melanocortin 3 receptor (MC3) activation effects on testicular testosterone and nitrite production in vitro2011
MC1 and MC3 activation inhibits caspase-3 production and activity, promotes cell-viability, and induces IL-10 and HO-1 release from human C20/A4 chondrocytes2010
Cartilage and macrophages: evidence for a paracrine loop. Poster no. 2782010
The effects of REV5901 on chondrocyte viability following mechanical trauma2010
Diurnal inflammatory cytokine changes post-exercise. Poster no. 3192010
REV5901: the protective effect on bovine articular chondrocytes following single impact trauma2010
REV5901: an investigation on the chondroprotective effect in bovine chondrocytes following single impact trauma2009
Pro-inflammatory mediator release from TNF-α stimulated C-20/A4 cells results in Col II degradation2007
Endogenous MC3R and inhibition of inflammatory arthritis. PC1122007
Crucial role for endogenous melanocortin type 3 receptor in mesenteric post-reperfusion injury. PC1061995
Effect of nitric oxide on basal and NMDA-evoked release of glutamate and aspartate release in vivoPopulated Collagen Hydrogel and Polyhydroxyalkanoate Composites: Novel Matrices for Cartilage Repair and Regeneration?
De Pascale, C., Marcello, E., Getting, S.J., Roy, I. and Locke, I.C. Forthcoming. Populated Collagen Hydrogel and Polyhydroxyalkanoate Composites: Novel Matrices for Cartilage Repair and Regeneration? OARSI World Congress on Osteoarthritis . Toronto, Canada 02 Mar - 05 May 2019
2016
The formyl peptide receptor 2 (Fpr2) agonist, Compound 43 (Cpd43), attenuates and promotes the release of pro-inflammatory, and anti-inflammatory cytokines, respectively2014
Acute hypoxia alters myotube size in vitro and myostatin signalling in vivo2014
Melanocortin 3 receptors (MC3) exert anti-inflammatory effects in mouse testicular inflammation by reducing nitric oxide (NO) release from Leydig cells2013
Neuroprotective efficacy of the endogenous neuropeptide Urocortin in a oxygen-glucose deprivation model of transient cerebral ischaemia with reperfusion2012
Expression of melanocortin 3 receptors (MC3) in the reproductive axes of both male and female mice2012
The anti-inflammatory effects of melanocortin peptides in lipopolysaccharide activated chondrocytes2011
REV5901 induces calcium dependant chondroprotective effects post in vitro mechanical loading2011
α-MSH and [DTRP]8-γ-MSH inhibit pro-inflammatory cytokine release from stimulated primary bovine chondrocytes2011
Total pituitary hormone content in wild type and MC3 null male and female mice2011
Comparison between the total pituitary hormone content in wild type and melanocortin 3 receptor (MC3) null male and female mice2010
Activation of testicular melanocortin 3 receptors (MC3-R) inhibits LH-stimulated testosterone production2010
A13/BACII, a novel bovine chondrocytic cell line with differentiation potential2010
Tamoxifen: chondroprotective effects post-mechanical trauma2010
REV5901: chondroprotective effects post mechanical trauma2010
Knee forces and inflammation: the effects of foot strike patterns and footwear2010
Chondroitin and glucosamine supplementation results in increased chondrocyte viability post mechanical trauma in vitro2010
α-MSH and dTRP8-γ-MSH inhibit TNF-α induced MMP 1 and 13 expression in human C20/A4 chondrocytes2010
Melanocortin peptides modulate pro-inflammatory mediator release from TNF-a stimulated C-20/A4 cells2010
The MC3 agonist dTRP8-γ-MSH inhibits IL-6 and IL-8 release from TNF-α stimulated C-20/A4 chondrocytes, an effect blocked by the MC3R antagonist SHU91192010
Testicular LH-stimulated testosterone production is inhibited by activation of melanocortin 3 receptors (MC3)2008
Melanocortin 3 receptor in the testes of mice2008
Inhibitory role of endogenous melanocortin type 3 receptor in the inflamed microcirculation2014
The melanocortin system in the male reproductive axis2012
The phenotypic characterization of A13/BACii, a novel bovine chondrocytic cell line with differentiation potential2012
Novel methods for the quantification of changes in actin organization in chondrocytes using fluorescent imaging and linear profiling2012
Leukocyte recruitment in the brain in sepsis: involvement of the annexin 1-FPR2/ALX anti-inflammatory system2011
The Melanocortin receptor system as an anti-inflammatory therapeutic target for stroke2011
Investigating the role of melanocortin receptor subtypes in mediating anti-inflammatory protection following cerebral ischemia reperfusion injury2011
Targeting the melanocortin receptor system for anti-stroke therapy2010
Anti-inflammatory and antiosteoclastogenesis propertiesof endogenous melanocortin receptor type 3 inexperimental arthritis2010
Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via Annexin-A1 mobilization2010
The melanocortin MC1 receptor agonist BMS-470539 inhibits leucocyte trafficking in the inflamed vasculature2010
Saliva: physiology and diagnostic potential in health and disease2009
The effects of REV5901 on chondrocyte viability following mechanical trauma2009
Molecular characterization of the melanocortin 3 receptor in the testes of mice2008
Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion2008
A role for MC3R in modulating lung inflammation2008
Melanocortin 3 receptor in the testes of mice2008
Asymmetric dimethylarginine negatively influences osteoblast differentiation in vitro2008
The role of the actin cytoskeleton in chondrocyte protection following single impact2008
Tonic inhibitory control of the mesenteric microcirculation by the melanocortin type 3 receptor2008
A role for melanocortin peptides in modulating oxidative stress induced inflammation in A549 cells2008
The effect of prolonged hypotonicity on chondrocyte volume regulation and intracellular calcium signalling2007
Glucocorticoid and melanocortins: special issue2006
[D -Trp8]-γ -melanocyte -stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1 R(Recessive Yellow e/e Mouse)2006
Annexin 1 and melanocortin peptide therapy for protection against ischaemic-reperfusion damage in the heart2006
Targeting melanocortin receptors as potential novel therapeutics2006
Melanocortin receptor signaling in RAW264.7 macrophage cell line2006
The melanocortin peptide HP228 displays protective effects in acute models of inflammation and organ damage2006
Mode of glucocorticoid actions in airway disease2006
Melanocortin 3 receptors control crystal-induced inflammation2005
In vitro and in vivo induction of heme oxygenase 1 in mouse macrophages following melanocortin receptor activation2004
MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct2004
Inhibitory effects of TSG-6 Link module on leukocyte-endothelial cell interactions in vitro and in vivo2004
Investigation into the potential anti-inflammatory effects of endothelin antagonists in a murine model of experimental monosodium urate peritonitis2004
Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis2004
The annexin 1-/- mouse: phenotypic studies2004
Activation of melanocortin receptors induces cAMP-dependent hemeoxygenase-1 expression in murine macrophages2004
Melanocortin receptor type 3 as a potential target for anti-inflammatory therapy2003
Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides2003
Redundancy of a Functional Melanocortin 1 Receptor in the Anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor2003
Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse2003
Migration of specific leukocyte subsets in response to cytokine or chemokine application in vivo2002
The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha -inhibitor-independent manner2002
The annexin-1 knockout mouse: what it tells us about the inflammatory response2002
Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor2002
Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis2002
Melanocortin peptides and their receptors: new targets for anti-inflammatory therapy2002
A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones2002
Characterization of CXC and CC chemokine expression in a murine model of chronic granuloma2001
Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics2001
Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase2001
Arthritic diseases: melanocortin type 3 receptor agonists as potential therapeutics2001
Natural and synthetic agonists of the melanocortin receptor type 3 possess anti-inflammatory properties2000
MC3-R as a novel target for anti-inflammatory therapy1999
POMC gene-derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation1997
Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts anti-inflammatory effects1997
Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins1997
Inhibition of neutrophil and monocyte recruitment by endogenous and exogenous lipocortin 11997
Sub-acute treatment of rats with dexamethasone reduces ICAM-1 levels on circulating monocytes1996
Biphasic modulation of GABA release by nitric oxide in the hippocampus of freely moving rats in vivo1995
Nitric oxide regulates excitatory amino acid release in a biphasic manner in freely moving rats2014
Melanocortin receptor expression in the hypothalamo-pituitary-gonadal system of WT and MC3 null mice2008
Melanocortins2003
Migration of specific leukocyte sub-sets in response to cytokine or chemokine application in vivo1998
Compounds for use in the treatment of inflammation