Authors | Clow, A., Freestone, C., Lewis, E., Dexter, D., Sandler, M. and Glover, V. |
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Abstract | It has previously been shown that both the dopamine receptor agonist, pergolide, and the monoamine oxidase inhibitor. (−)-deprenyl, can cause induction of CuZn superoxide dismutase in the rat striatum. We have now confirmed this effect of pergolide (0.04 mg/kg i.p.) as being localised to the striatum, but not the cerebellum, and shown it to take 3 weeks to develop. Furthermore, we have found that MDL 72974, a more specific monoamine oxidase inhibitor than (−)-deprenyl, failed to bring about such an induction either at a low selective monoamine oxidase B inhibitory dose, or at a higher non-selective dose. |
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