| Title | Effects of discontinuous drug administration on the development of dopamine receptor supersensitivity during chronic trifluoperazine or cis-flupenthixol administration to rats |
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| Authors | Murugaiah, K., Theodorou, A., Clow, A., Jenner, P. and Marsden, C.D. |
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| Abstract | Rats received continuous or discontinuous administration of trifluoperazine or cis-flupenthixol in drinking water for up to 12 months. Continuous and discontinuous trifluoperazine administration had no consistent effect on apomorphine-induced stereotyped behaviour and there was no difference between drug treatments. Continuous and discontinuous cis-flupenthixol administration enhanced apomorphine-induced stereotypy, but there was no difference in the effect of the two drug treatments. Both continuous and discontinuous administration of trifluoperazine increased the number of specific striatal 3H-spiperone binding sites (B max). Over the period of treatment there was no difference in the effects of the different treatments. Continuous or discontinuous cis-flupenthixol intake did not increase B max after 6 or 12 months intake. Continuous or discontinuous neuroleptic treatment produced no difference in functional striatal dopamine receptor activity as judged by apomorphine-induced stereotyped behaviour. Ligand binding studies also suggest that the overall change in striatal receptor function is not affected by the use of a discontinuous drug regime. |
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| Journal | Psychopharmacology |
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| Journal citation | 86 (1-2), pp. 228-232 |
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| ISSN | 0033-3158 |
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| Year | 1985 |
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| Publisher | Springer |
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| Digital Object Identifier (DOI) | https://doi.org/10.1007/BF00431715 |
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| Publication dates |
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| Published | 1985 |
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