Title | Inhibitory potency of some isatin analogues on human monoamine oxidase A and B |
---|
Authors | Medvedev, A.E., Goodwin, B.L., Clow, A., Halket, J., Glover, V. and Sandler, M. |
---|
Abstract | Isatin is an endogenous compound which acts as a selective inhibitor of monoamine oxidase (MAO) B. In this study a range of isatin analogues were tested for their in vitro inhibition of human MAO A and B. Most of the analogues were less potent than isatin. Hydroxylation of the aromatic ring changed the inhibitory potency in favour of MAO A, with 5-hydroxyisatin being a potent and selective MAO A inhibitor (ic50 8μM). Isatinic acid, which is formed reversibly from isatin at alkaline pH, showed no inhibition. |
---|
Journal | Biochemical Pharmacology |
---|
Journal citation | 44 (3), pp. 590-592 |
---|
ISSN | 0006-2952 |
---|
Year | 04 Aug 1992 |
---|
Publisher | Elsevier |
---|
Digital Object Identifier (DOI) | https://doi.org/10.1016/0006-2952(92)90454-Q |
---|
Publication dates |
---|
Published | 04 Aug 1992 |
---|