|Title||(−)-Deprenyl can induce soluble superoxide dismutase in rat striata|
|Authors||Clow, A., Hussain, T., Glover, V., Sandler, M., Dexter, D. and Walker, M.|
(–)-Deprenyl (0.25 or 2mg/kg) or saline was injected daily into male Wistar rats for 3 weeks. The striata were dissected out and soluble and particulate Superoxide dismutase activity measured. (–)-Deprenyl at 2mg/kg induced a significant increase in the soluble but not the particulate form of the enzyme. The possibility that this action contributes to the ability of (–)-deprenyl to retard nigral degeneration in man and prolong life in rats is discussed.
|Journal||Journal of Neural Transmission|
|Journal citation||86 (1), pp. 77-80|
|Digital Object Identifier (DOI)||https://doi.org/10.1007/BF01250378|