Title | (−)-Deprenyl can induce soluble superoxide dismutase in rat striata |
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Authors | Clow, A., Hussain, T., Glover, V., Sandler, M., Dexter, D. and Walker, M. |
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Abstract | (–)-Deprenyl (0.25 or 2mg/kg) or saline was injected daily into male Wistar rats for 3 weeks. The striata were dissected out and soluble and particulate Superoxide dismutase activity measured. (–)-Deprenyl at 2mg/kg induced a significant increase in the soluble but not the particulate form of the enzyme. The possibility that this action contributes to the ability of (–)-deprenyl to retard nigral degeneration in man and prolong life in rats is discussed. |
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Journal | Journal of Neural Transmission |
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Journal citation | 86 (1), pp. 77-80 |
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ISSN | 0300-9564 |
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Year | Feb 1991 |
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Publisher | Springer |
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Digital Object Identifier (DOI) | https://doi.org/10.1007/BF01250378 |
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