Prof Louise Thomas
Analysis of MRI-derived spleen iron in the UK Biobank identifies genetic variation linked to iron homeostasis and hemolysis
Sorokin, E., Basty, N., Whitcher, B., Liu, Y., Bell, J.D., Cohen, R.L., Cule, M. and Thomas, E.L. 2022. Analysis of MRI-derived spleen iron in the UK Biobank identifies genetic variation linked to iron homeostasis and hemolysis. American Journal of Human Genetics. 109 (6), pp. P1092-1104. https://doi.org/10.1016/j.ajhg.2022.04.013
Precision MRI Phenotyping Enables Detection of Small Changes in Body Composition for Longitudinal Cohorts
Whitcher, B., Thanaj, M., Cule, M., Liu, Y., Basty, N., Sorokin, E., Bell, J.D. and Thomas, E.L. 2022. Precision MRI Phenotyping Enables Detection of Small Changes in Body Composition for Longitudinal Cohorts. Scientific Reports. 12 3748. https://doi.org/10.1038/s41598-022-07556-y
Large‑scale analysis of iliopsoas muscle volumes in the UK Biobank
Fitzpatrick, J., Basty, N., Cule, M., Liu, Y., Bell, J.D., Thomas, E.L. and Whitcher, B. 2020. Large‑scale analysis of iliopsoas muscle volumes in the UK Biobank. Scientific Reports. 10 20215. https://doi.org/10.1038/s41598-020-77351-0
Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning.
Liu, Y., Basty, N., Whitcher, B., Bell, J.D., Sorokin, E., van Bruggen, Nick, Thomas, E.L. and Cule, M. 2021. Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning. eLife. 10. https://doi.org/10.7554/elife.65554
2024
Genetic evidence for distinct biological mechanisms that link adiposity to type 2 diabetes: towards precision medicine2024
Quantifying the effect of nutritional interventions on metabolic resilience using personalised computational models2024
Ultra Weak Photon Emission - A Brief Review2024
Precision MRI phenotyping of muscle volume and quality at a population scale2024
Liver Shape Analysis using Statistical Parametric Maps at Population Scale2023
Artifact-Free Fat-Water Separation in Dixon MRI using Deep Learning2023
Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models.2023
Kidney Shape Statistical Analysis: Associations with Disease and Anthropometric Factors2023
Non-chemical Signalling Between Mitochondria2023
Diet-induced weight loss and phenotypic flexibility among healthy overweight adults: a randomized trial2023
Abdominal imaging associates body composition with COVID-19 severity2022
Analysis of MRI-derived spleen iron in the UK Biobank identifies genetic variation linked to iron homeostasis and hemolysis2022
Precision MRI Phenotyping Enables Detection of Small Changes in Body Composition for Longitudinal Cohorts2022
Cell-Cell Death Communication by Signals Passing Through Non-Aqueous Environments: A Reply2022
The Mixed Meal Model: quantifying the contribution of 1 triglycerides to metabolic resilience.2022
Improving the accuracy of fatty liver index to reflect liver fat content with predictive regression modelling2022
Plasma metabolic signatures of healthy overweight subjects challenged with an oral glucose tolerance test2022
Infection with the hepatitis C virus causes viral genotype-specific differences in cholesterol metabolism and hepatic steatosis2022
Estimating the Effect of Liver and Pancreas Volume and Fat Content on Risk of Diabetes: A Mendelian Randomization Study2022
A cross-sectional MR study of body fat volumes and distribution in chronic schizophrenia2022
Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation2022
Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study2021
Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning.2021
Adipose tissue dysfunction, inflammation, and insulin resistance alternative pathways to cardiac remodelling in schizophrenia. A multimodal, case-control study2021
Genetic evidence for different adiposity phenotypes and their opposing influence on ectopic fat and risk of cardiometabolic disease2021
Cannabidiol modulates mitochondrial redox and dynamics in MCF7 cancer cells: a study using fluorescence lifetime imaging microscopy of NAD(P)H2021
Acetate induces growth arrest in colon cancer cells through modulation of mitochondrial function2021
Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study2020
Large‑scale analysis of iliopsoas muscle volumes in the UK Biobank2020
Ethnic Differences in Body Fat Deposition and Liver Fat Content in Two UK-Based Cohorts2020
Normalized indices derived from visceral adipose mass assessed by MRI and their correlation with markers for insulin resistance and prediabetes2020
Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI Direct study2020
Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts2020
Ethnic differences in adiposity and diabetes risk – insights from genetic studies2020
Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis2020
The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study2020
HDL-apoA-I kinetics in response to 16 weeks exercise training in men with non-alcoholic fatty liver disease (NAFLD)2020
Machine Learning Prediction of Susceptibility to Visceral Fat Associated Diseases2019
Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration2019
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium2019
LEAP2 changes with body mass and food intake in humans and mice2019
Genome-wide and abdominal MRI-imaging data provides evidence that a genetically determined favourable adiposity phenotype is characterized by lower ectopic liver fat and lower risk of type 2 diabetes, heart disease and hypertension2019
A Framework for Automatic Morphological Feature Extraction and Analysis of Abdominal Organs in MRI Volumes2019
Reference range of liver corrected T1 values in a population at low risk for fatty liver disease-a UK Biobank sub-study, with an appendix of interesting cases2019
Cannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cells2019
The effects of dietary supplementation with inulin and inulin-propionate ester on hepatic steatosis in adults with non-alcoholic fatty liver disease2018
Measurement of liver iron by magnetic resonance imaging in the UK Biobank population2018
Non-alcoholic fatty liver disease: relationship with cardiovascular risk markers and clinical endpoints2018
Body Composition Profiling in the UK Biobank Imaging Study2018
Plasma metabolome analysis identifies distinct human metabotypes in the postprandial state with different susceptibility to weight loss–mediated metabolic improvements2018
Cannabidiol (CBD) is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer2017
Characterisation of liver fat in the UK Biobank cohort2017
Cationic lipid-based nanoparticles mediate functional delivery of acetate to tumor cells in vivo leading to significant anticancer effects2016
Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study2016
Reprogramming of hepatic fat accumulation and 'browning' of adipose tissue by the short-chain fatty acid acetate2015
Dissociation between exercise-induced reduction in liver fat and changes in hepatic and peripheral glucose homeostasis in obese patients with Non-Alcoholic Fatty Liver Disease.2015
Effects of elevating colonic propionate on liver fat content in overweight adults with non-alcoholic fatty liver disease: a pilot study2015
A diet low in sugar reduces the production of atherogenic lipoproteins in men with high liver fat2014
The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism2014
Body Fat: our own Janus2012
Improved Glycaemia correlates with liver fat reduction in obese, type 2 diabetes, patients given glucagon-like peptide-1 (GLP-1) receptor agonists2012
Differential effects of two fermentable carbohydrates on central appetite regulation and body composition2010
Impact of Maternal Body Mass Index on Offspring Liver Lipid Depends on Mode of Delivery2010
Fatty acid oxidation rate is higher in obese women than obese men2008
Reduction in Total Lung Capacity in Obese Men: Role of Trunk Fat2007
Increased abdominal and visceral adiposity is manifest in Indian babies at birth2007
Impaired insulin-mediated non-esterified fatty acid suppression in patients with hepatic steatosis quantified using proton magnetic resonance spectroscopy2006
Prediction of specific absorption rate in mother and fetus associated with MRI examinations during pregnancy2005
Hepatic triglyceride content and its relation to body adiposity: a magnetic resonance imaging and proton magnetic resonance spectroscopy study2004
Familial partial lipodystrophy associated with compound heterozygosity for novel mutations in the LMNA gene1998
In vivo and in vitro hepatic phosphorus-31 magnetic resonance spectroscopy and electron microscopy in chronic ductopenic rejection of human liver allografts1996
An in vivo 13C magnetic resonance spectroscopic study of the relationship between diet and adipose tissue composition2023
Individuals with moderately raised liver fat show a greater increase in liver fat in response to a high sugar diet2022
Correction: Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation2021
Using Genetics to Uncouple Higher Adiposity from Its Adverse Metabolic Effects2019
Genetic studies of MRI liver fat content identify susceptibility variants with variable metabolic effects2019
PTU-028 Genome-wide association study of MRI liver iron content in UK biobank identifies 3 susceptibility variants2019
Genome-wide association study of MRI liver iron content in 9,800 individuals yields new insights into its link with hepatic and extrahepatic diseases2019
Subcutaneous Abdominal Fat Has a Stronger Association with Prediabetes than Visceral Fat in Young Indians2019
Genome-wide association studies of abdominal MRI scans identifies loci associated with liver fat and liver iron in the UK Biobank2018
Rifaximin in Non-Alcoholic Steatohepatitis: An Open-Label Pilot Study2018
Genome-Wide and Abdominal Imaging Data Characterizes Common Alleles Associated with Higher BMI and Subcutaneous Fat but Less Liver Fat and Lower Risk of Type 2 Diabetes2017
Impact of liver fat on the differential partitioning of hepatic triacylglycerol into VLDL subclasses on high and low sugar diets2017
Psoas major cross-sectional area: A potential marker of cardiorespiratory fitness2017
UK Biobank Study of Liver Iron Overload Shows Variable Penetrance of Different Genotypes2017
Non-invasive stratification of fatty liver disease with high-throughput multiparametric MRI2016
Effect of energy restriction and physical exercise intervention on phenotypic flexibility as examined by transcriptomics analyses of mRNA from adipose tissue and whole body magnetic resonance imaging2016
Exercise Training Reduces Liver Fat and Increases Rates of VLDL Clearance, but not VLDL Production in NAFLD2016
Feasibility of MR-Based Body Composition Analysis in Large Scale Population Studies2016
Nutritional Evaluation and Optimisation in Neonates: a randomized, double-blind controlled trial of amino acid regimen and intravenous lipid composition in preterm parenteral nutrition2016
Nutritional Evaluation and Optimisation in Neonates (NEON) trial of amino acid regimen and intravenous lipid composition in preterm parenteral nutrition: a randomised double-blind controlled trial2016
Liver fat in adults with GH deficiency: comparison to matched controls and the effect of GH replacement2016
Investigating the lipodystrophy genetic score associations with insulin sensitivity, ectopic and visceral fat in people at risk or with diabetes: a DIRECT study2015
A randomized controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes.2015
Validation of a fast method for quantification of intra-abdominal and subcutaneous adipose tissue for large-scale human studies2015
Sexual dimorphism in relation to adipose tissue and intrahepatocellular lipid deposition in early infancy2015
Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults.2015
Circulating pancreatic polypeptide concentrations predict visceral and liver fat content2015
Body fat MRS2015
Effects of Elevating Colonic Propionate on Liver Fat Content in Adults with Non-Alcoholic Fatty Liver Disease2015
Exercise training alters VLDL TG and apoB metabolism in men with non-alcoholic liver disease (NAFLD)2014
External validation of the fatty liver index and lipid accumulation product indices, using 1H-magnetic resonance spectroscopy, to identify hepatic steatosis in healthy controls and obese, insulin-resistant individuals2014
The association between objectively measured sitting and standing with body composition: a pilot study using magnetic resonance imaging2014
Preterm nutritional intake and MRI phenotype at term age: a prospective observational study2014
Efficacy of increased resistant starch consumption in human type 2 diabetes2014
The impact of oligofructose on stimulation of gut hormones, appetite regulation and adiposity2014
Adiposity and hepatic lipid in healthy full-term, breastfed, and formula-fed human infants: a prospective short-term longitudinal cohort study2014
Targeted delivery of propionate to the human colon prevents body weight and intra-abdominal adipose tissue gain in overweight adults2013
A history of previous gestational diabetes mellitus is associated with adverse changes in insulin secretion and VLDL metabolism independently of increased intrahepatocellular lipid2013
Early nutritional determinants of intrahepatocellular lipid deposition in preterm infants at term age2013
Whole body fat: content and distribution2012
Polycystic ovary syndrome with hyperandrogenism is characterized by an increased risk of hepatic steatosis compared to nonhyperandrogenic PCOS phenotypes and healthy controls, independent of obesity and insulin resistance2012
Gender differences in VLDL1 and VLDL2 triglyceride kinetics and fatty acid kinetics in obese postmenopausal women and obese men2012
Fatty acid flux and oxidation are increased by rimonabant in obese women2012
Intrahepatic insulin exposure, intrahepatocellular lipid and regional body fat in non-alcoholic fatty liver disease2012
Hepatic steatosis, GH deficiency and the effects of GH replacement: a Liverpool magnetic resonance spectroscopy study2012
The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat2012
Fermentable carbohydrate alters hypothalamic neuronal activity and protects against the obesogenic environment2012
Relation between trunk fat volume and reduction of total lung capacity in obese men2012
Excess body fat in obese and normal weight subjects2012
The effect of preterm birth on adiposity and metabolic pathways and the implications for later life2011
Pragmatic study of orlistat 60 mg on abdominal obesity2011
Aberrant adiposity and ectopic lipid deposition characterize the adult phenotype of the preterm infant2011
The influence of maternal body mass index on infant adiposity and hepatic lipid content2011
Rapid reductions in left ventricular mass following a community based 12-week prevention programme are partially predicted by change in fat depots2011
Mechanism for the Differential Effect of the Long-Acting Insulin Analog Detemir on Weight in Patients with Type 2 Diabetes2011
Effects of 8 weeks oligofructose supplementation on appetite and body weight in overweight and obese adults2011
Impact of liver fat on the response of plasma triacylglycerol to diets high and low in extrinsic sugars2010
Estimation of abdominal fat compartments by bioelectrical impedance: the validity of the ViScan measurement system in comparison with MRI2010
Proton magnetic resonance spectroscopy and ultrasound for hepatic fat quantification2010
Reduction of total lung capacity in obese men: comparison of total intrathoracic and gas volumes2010
Resistant starch improves insulin sensitivity in metabolic syndrome2009
Fat distribution in men of different waist girth, fitness level and exercise habit2009
Whole body magnetic resonance imaging of healthy newborn infants demonstrates increased central adiposity in Asian Indians2009
Incidental findings in healthy control research subjects using whole-body MRI2009
Obesity, diabetes and longevity in the Gulf: is there a Gulf metabolic syndrome?2009
Lean Body Mass is Reduced in Preterm Infants at Term Age2008
Neonatal intrahepatocellular lipid2008
Non-invasive means of measuring hepatic fat content2008
Intra-Hepatic Insulin Exposure is Increased in Subjects with Non-Alcoholic Fatty Liver Disease (NAFLD)2008
Intra-hepatic insulin exposure but not percent extraction of newly-secreted insulin is increased in subjects with non-alcoholic fatty liver disease (NAFLD)2007
Pioglitazone added to conventional lipid lowering treatment in familial combined hyperlipidaemia improves parameters of metabolic control: relation to liver, muscle and regional body fat content2007
Creatine supplements in patients with idiopathic inflammatory myopathies who are clinically weak after conventional pharmacologic treatment: Six-month, double-blind, randomized, placebo-controlled trial2007
Exercise training reduces fatty acid availability and improves the insulin sensitivity of glucose metabolism2007
Exploratory, randomised, double-blind, controlled trial of breast milk fortifier containing long chain polyunsaturated fatty acids (LCPUFA) in pre term (PT) infants: effects on term body composition2007
Relationship between intrahepatocellular lipid content and features of the metabolic syndrome in subjects with known nonalcoholic fatty liver disease and healthy volunteers2006
Critical role for peptide YY in protein-mediated satiation and body-weight regulation2006
Effect of nutritional counselling on hepatic, muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease2006
Determinants of adiposity during preweaning postnatal growth in appropriately grown and growth-restricted term infants2006
Intra-cellular fat accumulation: mechanisms and implications for health2006
Are ethnic differences in body composition present at birth?2005
Excess visceral and hepatic adipose tissue in Turner syndrome determined by magnetic resonance imaging: estrogen deficiency associated with hepatic adipose content2005
Altered adiposity after extremely preterm birth2005
Preterm infants at term show increased intrahepatocellular lipid content on proton magnetic resonance spectroscopy2004
Elevated fasting plasma ghrelin in Prader-Willi Syndrome adults is not solely explained by their reduced visceral adiposity and insulin resistance2004
Distribution of adipose tissue in the newborn2004
Determinants of altered adipose tissue deposition in preterm infants at term2004
The effect of long term exercise on intrahepatic lipid and the insulin sensitivity of glucose and fatty acid metabolism in sedentary male subjects2003
Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-γ2003
Carbohydrate-induced manipulation of insulin sensitivity independently of intramyocellular lipids2003
Influence of undersampling on magnetic resonance imaging measurements of intra-abdominal adipose tissue2003
Altered deposition of adipose tissue after extremely preterm birth2002
Letter: Digenic inheritance of severe insulin resistance in a human pedigree2002
Fast and reproducible method for the direct quantitation of adipose tissue in newborn infants2002
Resting metabolic rate, plasma leptin concentrations, leptin receptor expression, and adipose tissue measured by whole-body magnetic resonance imaging in women with Prader-Willi syndrome2001
Visceral adipose tissue and metabolic complications of obesity are reduced in Prader-Willi syndrome female adults: evidence for novel influences on body fat distribution2000
In vivo evaluation of the effects of continuous exercise on skeletal muscle triglycerides in trained humans2000
Preferential loss of visceral fat following aerobic exercise, measured by magnetic resonance imaging1999
Angiotensin-converting-enzyme gene insertion/deletion polymorphism and response to physical training1999
Diversity in levels of intracellular total creatine and triglycerides in human skeletal muscles observed by 1H-MRS1999
Relation of triglyceride stores in skeletal muscle cells to central obesity and insulin sensitivity in European and South Asian men1998
Magnetic resonance imaging of total body fat1998
Critical assessment of in vivo13C NMR spectroscopy and gas–liquid chromatography in the study of adipose tissue composition1998
Intracellular and extracellular skeletal muscle triglyceride metabolism during alternating intensity exercise in humans1998
Human gene for physical performance1997
In vivo assessment of metabolic perturbations following alanine and glucagon administration using 31P-MRS in the rat1997
Noninvasive characterization of neonatal adipose tissue by 13C magnetic resonance spectroscopy1997
Changes in adipose tissue composition in malnourished patients before and after liver transplantation: A carbon-13 magnetic resonance spectroscopy and gas-liquid chromatography study1996
Effects of n-3 fatty acids on the NMR profile of plasma lipoproteins1996
Development of a rapid and efficient magnetic resonance imaging technique for analysis of body fat distribution1996
Automated feature extraction for the classification of human in vivo13C NMR spectra using statistical pattern recognition and wavelets1995
Cirrhosis of the human liver: an in vitro 31P nuclear magnetic resonance study2021
Mass Univariate Regression Analysis for Three-Dimensional Liver Image-Derived Phenotypes2021
3D Deep Learning for Anatomical Structure Segmentation in Multiple Imaging Modalities2020
Automated Measurement of Pancreatic Fat and Iron Concentration Using Multi-Echo and T1-Weghted MRI Data2019
Advancing Pancreas Segmentation in Multi-protocol MRI Volumes using Hausdorff-Sine Loss Function2019
Machine Learning Classification of Females Susceptibility to Visceral Fat Associated Diseases2017
A Framework for Morphological Feature Extraction of Organs from MR Images for Detection and Classification of Abnormalities2013
Metabolic syndrome, overweight and fatty liver2003
Hypothalamic neuropeptides and regulation of fat mass in Prader-Willi syndrome1999
Body fat metabolism: observation by MR imaging and spectroscopy1999
Magnetic resonance: in-vivo NMR, applications – other nuclei2024
Preprint: MRI assessment of adipose tissue fatty acid composition in the UK Biobank and its association with diet and disease2023
Preprint: Kidney Shape Statistical Analysis: Associations with Disease and Anthropometric Factors2023
Preprint: Precision MRI phenotyping of muscle volume and quality at a population scale2023
Preprint: Cardiovascular measures from abdominal MRI provide insights into abdominal vessel genetic architecture2023
Preprint: Liver Shape Analysis using Statistical Parametric Maps at Population Scale2021
Preprint: Swap-Free Fat-Water Separation in Dixon MRI using Conditional Generative Adversarial Networks2021
Preprint: Body fat volumes and distribution in chronic schizophrenia compared to healthy controls; a cross-sectional MR study2021
Preprint: Using genetics to uncouple higher adiposity from its adverse metabolic effects and understand its role in metabolic and non-metabolic disease2020
Preprint: Image Processing and Quality Control for Abdominal Magnetic Resonance Imaging in the UK Biobank2020
Preprint: Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study