| Description | Background: Central obesity has been associated with cardiometabolic diseases. Unlike in the white Caucasians, the abdominal subcutaneous adiposity has been associated with higher cardiometabolic risk in Indians. There are few studies in young Indians. We investigated associations of MRI measured abdominal subcutaneous adipose tissue (aSAT) and visceral adipose tissue (VAT) with cardiometabolic risk markers in young lean rural Indian adults. Methods: We measured aSAT and VAT adiposity by MRI in young adult participants in the PMNS cohort [18yrs, n=590 (310 men)]. We used multiple regression analysis to investigate their associations with a range of cardiometabolic risk markers (glucose-insulin indices, blood pressure, lipids, and inflammatory markers). Results: In multiple regression models, aSAT was significantly positively associated with 120-min OGTT glucose, insulinogenic index, total cholesterol, triglycerides, leptin, total leukocyte count, CRP and systolic and diastolic blood pressure, and negatively with Matsuda index and adiponectin. aSAT associations were stronger than VAT for most outcomes. In women, aSAT was associated with all parameters except HDL-cholesterol, whereas in men the associations were similar to those observed in the combined analyses. Conclusion: In young Indians, aSAT is associated with insulin resistance, dyslipidaemia, and inflammation, unlike in Western populations. Utility of targeting aSAT to prevent cardiometabolic diseases needs to be further investigated. |
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