Chemistry of tumour targeted T1 based MRI contrast agents

Kamaly, N., Miller, A.D. and Bell, J.D. 2010. Chemistry of tumour targeted T1 based MRI contrast agents. Current Topics in Medicinal Chemistry. 10 (12), pp. 1158-1183.

TitleChemistry of tumour targeted T1 based MRI contrast agents
AuthorsKamaly, N., Miller, A.D. and Bell, J.D.
Abstract

For effective tumour imaging by magnetic resonance imaging (MRI) there is a clear need to develop organ, tissue and cell specific contrast agents that can selectively bind to tumour biomarkers. The versatility of a range of bioconjugation techniques and facile coupling chemistries has facilitated the synthesis of MRI contrast agents bearing tumour targeting moieties that comprise small molecule affinity ligands, peptides, antibodies and even proteins. The aim of this review is to describe the development and implementation of tumour targeted T1 MRI contrast agents, with an emphasis on the chemistry used to modify pre-existing clinical MRI contrast agents for targeted tumour imaging.

JournalCurrent Topics in Medicinal Chemistry
Journal citation10 (12), pp. 1158-1183
ISSN1568-0266
Year2010
PublisherBentham Science Publishers
Digital Object Identifier (DOI)doi:10.2174/156802610791384199
Publication dates
Published2010

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Gender differences in VLDL1 and VLDL2 triglyceride kinetics and fatty acid kinetics in obese postmenopausal women and obese men
Sarac, I., Backhouse, K., Shojaee-Moradie, F., Stolinski, M., Robertson, M.D., Bell, J.D., Thomas, E.L., Hovorka, R., Wright, J. and Umpleby, A.M. 2012. Gender differences in VLDL1 and VLDL2 triglyceride kinetics and fatty acid kinetics in obese postmenopausal women and obese men. Journal of Clinical Endocrinology and Metabolism. 97 (7), pp. 2475-2481.

Excess body fat in obese and normal weight subjects
Thomas, E.L., Frost, G.S., Taylor-Robinson, S.D. and Bell, J.D. 2012. Excess body fat in obese and normal weight subjects. Nutrition Research Reviews. 25 (1), pp. 150-161.

The effect of preterm birth on adiposity and metabolic pathways and the implications for later life
Thomas, E.L., Al Saud, N.B., Durighel, G., Frost, G.S. and Bell, J.D. 2012. The effect of preterm birth on adiposity and metabolic pathways and the implications for later life. Clinical Lipidology. 7 (3), pp. 275-288.

Elemental imaging of MRI contrast agents: benchmarking of LA-ICP-MS to MRI
Pugh, J.A.T., Cox, A.G., McLeod, C.W., Bunch, J., Writer, M.J., Hart, S.L., Bienemann, A., White, E. and Bell, J.D. 2012. Elemental imaging of MRI contrast agents: benchmarking of LA-ICP-MS to MRI. Analytical and bioanalytical chemistry. 403 (6), pp. 1641-1649.

Intrahepatic insulin exposure, intrahepatocellular lipid and regional body fat in non-alcoholic fatty liver disease
Mehta, S.R., Godsland, I.F., Thomas, E.L., Pavitt, D.V., Morin, S.H.X., Bell, J.D., Taylor-Robinson, S.D. and Johnston, D.G. 2012. Intrahepatic insulin exposure, intrahepatocellular lipid and regional body fat in non-alcoholic fatty liver disease. Journal of Clinical Endocrinology and Metabolism. 97 (6), pp. 2151-2159.

Hepatic steatosis, GH deficiency and the effects of GH replacement: a Liverpool magnetic resonance spectroscopy study
Gardner, C.J., Irwin, A., Daousi, C., McFarlane, I.A., Joseph, F., Bell, J.D., Thomas, E.L., Adams, V.L., Kemp, G.J. and Cuthbertson, D.J. 2012. Hepatic steatosis, GH deficiency and the effects of GH replacement: a Liverpool magnetic resonance spectroscopy study. European Journal of Endocrinology. 166, pp. 993-1002.

Fermentable carbohydrate alters hypothalamic neuronal activity and protects against the obesogenic environment
Anastasovska, J., Arora, T., Sanchez-Canon, G.J., Parkinson, J.R.C., Touhy, K., Gibson, G.R., Nadkarni, N., So, P.W., Goldstone, A.P., Thomas, E.L., Hankir, M., Van Loo, J., Modi, N., Bell, J.D. and Frost, G.S. 2012. Fermentable carbohydrate alters hypothalamic neuronal activity and protects against the obesogenic environment. Obesity. 20 (5), pp. 1016-1023.

Validation of dual energy x-ray absorptiometry measures of abdominal fat by comparison with magnetic resonance imaging in an Indian population
Taylor, A.E., Kuper, H., Varma, R.D., Wells, J.C.K., Bell, J.D., Radhakrishna, K.V., Kulkarni, B., Kinra, S., Timpson, N.J., Ebrahim, S., Smith, G.D. and Ben-Shlomo, Y. 2012. Validation of dual energy x-ray absorptiometry measures of abdominal fat by comparison with magnetic resonance imaging in an Indian population. PLoS ONE. 7 (12), p. e51042.

Metabolic profiling of the rat liver after chronic ingestion of alpha-naphthylisothiocyanate using in vivo and ex vivo magnetic resonance spectroscopy
Solanky, B.S., Sanchez-Canon, G.J., Cobbold, J.F.L., Taylor-Robinson, S.D., Bell, J.D., Scudamore, C.L., Ross, E., Holder, J.C., So, P.W. and Cox, I.J. 2012. Metabolic profiling of the rat liver after chronic ingestion of alpha-naphthylisothiocyanate using in vivo and ex vivo magnetic resonance spectroscopy. Toxicological Sciences. 126 (2), pp. 306-316.

Increased energy expenditure in gastric bypass rats is not caused by activated brown adipose tissue
Hankir, M., Bueter, M., Gsell, W., Seyfried, F., Khalil, M., Smith, K.L., Bloom, S.R., Bell, J.D. and le Roux, C.W. 2012. Increased energy expenditure in gastric bypass rats is not caused by activated brown adipose tissue. Obesity Facts. 5 (3), pp. 349-358.

Relation between trunk fat volume and reduction of total lung capacity in obese men
Watson, R.A., Pride, N.B., Thomas, E.L., Ind, P.W. and Bell, J.D. 2012. Relation between trunk fat volume and reduction of total lung capacity in obese men. Journal of Applied Physiology. 112 (1), pp. 118-126.

The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat
Thomas, E.L., Parkinson, J.R.C., Frost, G.S., Goldstone, A.P., Doré, C.J., McCarthy, J., Collins, A.L., Fitzpatrick, J., Durighel, G., Taylor-Robinson, S.D. and Bell, J.D. 2012. The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat. Obesity. 20 (1), pp. 76-87.

The effects of glutamate receptor agonists and antagonists on mouse hypothalamic and hippocampal neuronal activity shown through manganese enhanced MRI
Hankir, M., Parkinson, J.R.C., Bloom, S.R. and Bell, J.D. 2012. The effects of glutamate receptor agonists and antagonists on mouse hypothalamic and hippocampal neuronal activity shown through manganese enhanced MRI. NeuroImage. 59 (2), pp. 968-978.

A low molecular weight folate receptor targeted contrast agent for magnetic resonance tumour imaging
Kalber, T., Kamaly, N., So, P.W., Pugh, J.A.T., Bunch, J., McLeod, C.W., Jorgensen, M.R., Miller, A.D. and Bell, J.D. 2011. A low molecular weight folate receptor targeted contrast agent for magnetic resonance tumour imaging. Molecular Imaging and Biology. 13 (4), pp. 653-662.

Synthesis and characterisation of a novel tubulin-directed DO3A–colchicine conjugate with potential theranostic features
Wardle, N.J., Kalber, T., Bell, J.D. and Bligh, S.W.A. 2011. Synthesis and characterisation of a novel tubulin-directed DO3A–colchicine conjugate with potential theranostic features. Bioorganic and Medicinal Chemistry Letters. 21 (11), pp. 3346-3348.

Peptide YY3-36 and pancreatic polypeptide differentially regulate hypothalamic neuronal activity in mice in vivo as measured by manganese-enhanced magnetic resonance imaging
Hankir, M., Parkinson, J.R.C., Minnion, J.S., Addison, M.L., Bloom, S.R. and Bell, J.D. 2011. Peptide YY3-36 and pancreatic polypeptide differentially regulate hypothalamic neuronal activity in mice in vivo as measured by manganese-enhanced magnetic resonance imaging. Journal of Neuroendocrinology. 23 (4), pp. 371-380.

Novel multifunctional nanoparticle mediates siRNA tumour delivery, visualisation and therapeutic tumour reduction in vivo
Kenny, G., Kamaly, N., Kalber, T., Brody Leigh, Sahuri-Arisoylu Meliz, Shamsaei, E., Miller, A.D. and Bell, J.D. 2011. Novel multifunctional nanoparticle mediates siRNA tumour delivery, visualisation and therapeutic tumour reduction in vivo. Journal of Controlled Release. 149 (2), pp. 111-116.

Aberrant adiposity and ectopic lipid deposition characterize the adult phenotype of the preterm infant
Thomas, E.L., Parkinson, J.R.C., Hyde, M.J., Yap, I.K.S., Holmes, E., Doré, C.J., Bell, J.D. and Modi, N. 2011. Aberrant adiposity and ectopic lipid deposition characterize the adult phenotype of the preterm infant. Paediatric Research. 70 (5), pp. 507-512.

Pragmatic study of orlistat 60 mg on abdominal obesity
Thomas, E.L., Makwana, A., Newbould, R., Rao, A.W., Gambarota, G., Frost, G.S., Delafont, B., Mishra, R.G., Matthews, P.M., Berk, E.S., Schwartz, S.M., Bell, J.D. and Beaver, J.D. 2011. Pragmatic study of orlistat 60 mg on abdominal obesity. European Journal of Clinical Nutrition. 65, pp. 1256-1262.

Targeting of anionic membrane species by lanthanide(III) complexes: towards improved MRI contrast agents for apoptosis
Surman, A.J., Kenny, G., Krishna Kumar, D., Bell, J.D., Casey, D.R. and Vilar, R. 2011. Targeting of anionic membrane species by lanthanide(III) complexes: towards improved MRI contrast agents for apoptosis. Chemical Communications. 47, pp. 10245-10247.

The influence of maternal body mass index on infant adiposity and hepatic lipid content
Modi, N., Murgasova, D., Ruager-Martin, R., Thomas, E.L., Hyde, M.J., Gale, C., Santhakumaran, S., Doré, C.J., Alavi, Afshin and Bell, J.D. 2011. The influence of maternal body mass index on infant adiposity and hepatic lipid content. Paediatric Research. 70 (3), pp. 287-291.

Synthesis and characterization of a theranostic vascular disrupting agent for in vivo MR imaging
Kalber, T., Kamaly, N., Higham, S.A., Pugh, J.A.T., Bunch, J., McLeod, C.W., Miller, A.D. and Bell, J.D. 2011. Synthesis and characterization of a theranostic vascular disrupting agent for in vivo MR imaging. Bioconjugate Chemistry. 22 (5), pp. 879-886.

A pyrophosphate-responsive gadolinium(III) MRI contrast agent
Surman, A.J., Bonnet, C.S., Lowe, M.P., Kenny, G., Bell, J.D., Tóth, É. and Vilar, R. 2011. A pyrophosphate-responsive gadolinium(III) MRI contrast agent. Chemistry: A European Journal. 17 (1), pp. 223-230.

Manganese enhancement in non-CNS organs
Lee, L.W., So, P.W., Price, A.N., Parkinson, J.R.C., Larkman, D.J., Halliday, J., Poucher, S.M., Pugh, J.A.T., Cox, A.G., McLeod, C.W. and Bell, J.D. 2010. Manganese enhancement in non-CNS organs. NMR in Biomedicine. 23 (8), pp. 931-938.

Endocannabinoids, FOXO and the metabolic syndrome: redox, function and tipping point – the view from two systems
Nunn, A.V.W., Guy, G.W. and Bell, J.D. 2010. Endocannabinoids, FOXO and the metabolic syndrome: redox, function and tipping point – the view from two systems. Immunobiology. 215 (8), pp. 617-628.

Imaging of gadolinium spatial distribution in tumor tissue by laser ablation inductively coupled plasma mass spectrometry
Kamaly, N., Pugh, J.A.T., Kalber, T., Bunch, J., Miller, A.D., McLeod, C.W. and Bell, J.D. 2010. Imaging of gadolinium spatial distribution in tumor tissue by laser ablation inductively coupled plasma mass spectrometry. Molecular Imaging and Biology. 12 (4), pp. 361-366.

Peripherally injected cholecystokinin-induced neuronal activation is modified by dietary composition in mice
Zeeni, N., Nadkarni, N., Bell, J.D., Even, P.C., Fromentin, G., Tome, D. and Darcel, N. 2010. Peripherally injected cholecystokinin-induced neuronal activation is modified by dietary composition in mice. NeuroImage. 50 (4), pp. 1560-1565.

The combined effects on neuronal activation and blood–brain barrier permeability of time and n-3 polyunsaturated fatty acids in mice, as measured in vivo using MEMRI
Kuo, Y.T., So, P.W., Parkinson, J.R.C., Yu, W.S., Hankir, M., Herlihy, A.H., Goldstone, A.P., Frost, G.S., Wasserfall, C. and Bell, J.D. 2010. The combined effects on neuronal activation and blood–brain barrier permeability of time and n-3 polyunsaturated fatty acids in mice, as measured in vivo using MEMRI. NeuroImage. 50 (4), pp. 1384-1391.

Proton magnetic resonance spectroscopy and ultrasound for hepatic fat quantification
Mehta, S.R., Thomas, E.L., Patel, N., Crofton, M.E., McCarthy, J., Eliahoo, J., Morin, S.H.X., Fitzpatrick, J., Durighel, G., Goldstone, A.P., Johnston, D.G., Bell, J.D. and Taylor-Robinson, S.D. 2010. Proton magnetic resonance spectroscopy and ultrasound for hepatic fat quantification. Hepatology Research. 40 (4), pp. 399-406.

Resistant starch improves insulin sensitivity in metabolic syndrome
Johnston, K.L., Thomas, E.L., Bell, J.D., Frost, G.S. and Robertson, M.D. 2010. Resistant starch improves insulin sensitivity in metabolic syndrome. Diabetic Medicine. 27 (4), pp. 391-397.

Reduction of total lung capacity in obese men: comparison of total intrathoracic and gas volumes
Watson, R.A., Pride, N.B., Thomas, E.L., Fitzpatrick, J., Durighel, G., McCarthy, J., Morin, S.H.X., Ind, P.W. and Bell, J.D. 2010. Reduction of total lung capacity in obese men: comparison of total intrathoracic and gas volumes. Journal of Applied Physiology. 108 (6), pp. 1605-1612.

Estimation of abdominal fat compartments by bioelectrical impedance: the validity of the ViScan measurement system in comparison with MRI
Thomas, E.L., Collins, A.L., McCarthy, J., Fitzpatrick, J., Durighel, G., Goldstone, A.P. and Bell, J.D. 2010. Estimation of abdominal fat compartments by bioelectrical impedance: the validity of the ViScan measurement system in comparison with MRI. European Journal of Clinical Nutrition. 64, pp. 525-533.

Efficient and rapid labelling of transplanted cell populations with superparamagnetic iron oxide nanoparticles using cell surface chemical biotinylation for in vivo monitoring by MRI
So, P.W., Kalber, T., Hunter, D., Farquharson, M., Al-Ebraheem, A., Parkes, H.G., Simon, R. and Bell, J.D. 2010. Efficient and rapid labelling of transplanted cell populations with superparamagnetic iron oxide nanoparticles using cell surface chemical biotinylation for in vivo monitoring by MRI. Cell Transplantation. 19 (4), pp. 419-429.

Inflammatory modulation of exercise salience: using hormesis to return to a healthy lifestyle
Nunn, A.V.W., Guy, G.W., Brodie, J.S. and Bell, J.D. 2010. Inflammatory modulation of exercise salience: using hormesis to return to a healthy lifestyle. Nutrition & Metabolism. 7, p. 87.

A novel bimodal lipidic contrast agent for cellular labelling and tumour MRI
Kamaly, N., Kalber, T., Kenny, G., Bell, J.D., Jorgensen, M.R. and Miller, A.D. 2010. A novel bimodal lipidic contrast agent for cellular labelling and tumour MRI. Organic and Biomolecular Chemistry. 8, pp. 201-211.

Incidental findings in healthy control research subjects using whole-body MRI
Morin, S.H.X., Cobbold, J.F.L., Lim, A.K.P., Eliahoo, J., Thomas, E.L., Mehta, S.R., Durighel, G., Fitzpatrick, J., Bell, J.D. and Taylor-Robinson, S.D. 2009. Incidental findings in healthy control research subjects using whole-body MRI. European Journal of Radiology. 72 (3), pp. 529-533.

Dominant role of the p110β isoform of PI3K over p110α in energy homeostasis regulation by POMC and AgRP neurons
Al-Qassab, H., Smith, M.A., Irvine, E.E., Guillermet-Guibert, J., Claret, M., Choudhury, A.I., Selman, C., Piipari, K., Clements, M., Lingard, S., Chandarana, K., Bell, J.D., Barsh, G.S., Smith, A.J.H., Batterham, R.L., Ashford, M.L.J., Vanhaesebroeck, B. and Withers, D.J. 2009. Dominant role of the p110β isoform of PI3K over p110α in energy homeostasis regulation by POMC and AgRP neurons. Cell Metabolism. 10 (5), pp. 343-354.

Fasting biases brain reward systems towards high-calorie foods
Goldstone, A.P., Prechtl de Hernandez, C.G., Beaver, J.D., Muhammed, K., Croese, C., Bell, G., Durighel, G., Hughes, E., Waldman, A.D., Frost, G.S. and Bell, J.D. 2009. Fasting biases brain reward systems towards high-calorie foods. European Journal of Neuroscience. 30 (8), pp. 1625-1635.

Cerebral activation by fasting induces lactate accumulation in the hypothalamus
Violante, I.R., Anastasovska, J., Sanchez-Canon, G.J., Rodrigues, T.B., Righi, V., Nieto-Charques, L., Parkinson, J.R.C., Bloom, S.R., Bell, J.D. and Cerdan Sebastian 2009. Cerebral activation by fasting induces lactate accumulation in the hypothalamus. Magnetic Resonance in Medicine. 62 (2), pp. 279-283.

Obesity, diabetes and longevity in the Gulf: is there a Gulf metabolic syndrome?
Guy, G.W., Nunn, A.V.W., Thomas, E.L. and Bell, J.D. 2009. Obesity, diabetes and longevity in the Gulf: is there a Gulf metabolic syndrome? International Journal of Diabetes Mellitus. 1 (1), pp. 43-54.

Differential patterns of neuronal activation in the brainstem and hypothalamus following peripheral injection of GLP-1, oxyntomodulin and lithium chloride in mice detected by manganese-enhanced magnetic resonance imaging (MEMRI)
Parkinson, J.R.C., Chaudhri, O.B., Kuo, Y.T., Field, B.C.T., Herlihy, A.H., Dhillo, W.S., Ghatei, M.A., Bloom, S.R. and Bell, J.D. 2009. Differential patterns of neuronal activation in the brainstem and hypothalamus following peripheral injection of GLP-1, oxyntomodulin and lithium chloride in mice detected by manganese-enhanced magnetic resonance imaging (MEMRI). NeuroImage. 44 (3), pp. 1022-1031.

The application of magnetic resonance imaging and spectroscopy to gene therapy
So, P.W., Bhakoo, K.K., Cox, I.J., Taylor-Robinson, S.D. and Bell, J.D. 2009. The application of magnetic resonance imaging and spectroscopy to gene therapy. in: Conn, P.M. (ed.) Essential bioimaging methods Academic Press. pp. 374-398

Diagonal-SPRITE and its applications for in vivo imaging at high field
Protti, A., Herlihy, A.H., So, P.W., Tessier, J., Kalber, T. and Bell, J.D. 2009. Diagonal-SPRITE and its applications for in vivo imaging at high field. The Open Magnetic Resonance Journal. 2, pp. 1-7.

Imaging appetite regulating pathways in the central nervous system using manganese enhanced magnetic resonance imaging (MEMRI)
Parkinson, J.R.C., Chaudhri, O.B. and Bell, J.D. 2009. Imaging appetite regulating pathways in the central nervous system using manganese enhanced magnetic resonance imaging (MEMRI). Neuroendocrinology. 89 (2), pp. 121-130.

Fat distribution in men of different waist girth, fitness level and exercise habit
O'Donovan, G., Thomas, E.L., McCarthy, J., Fitzpatrick, J., Durighel, G., Mehta, S.R., Morin, S.H.X., Goldstone, A.P. and Bell, J.D. 2009. Fat distribution in men of different waist girth, fitness level and exercise habit. International Journal of Obesity. 33 (12), pp. 1356-1362.

Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe?
Nunn, A.V.W., Bell, J.D. and Guy, G.W. 2009. Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe? Nutrition & Metabolism. 6, p. 16.

Whole body magnetic resonance imaging of healthy newborn infants demonstrates increased central adiposity in Asian Indians
Modi, N., Thomas, E.L., Uthaya, S.N., Umranikar, S., Bell, J.D. and Yajnik, C. 2009. Whole body magnetic resonance imaging of healthy newborn infants demonstrates increased central adiposity in Asian Indians. Paediatric Research. 65 (5), pp. 584-587.

Folate receptor targeted bimodal liposomes for tumor magnetic resonance imaging
Kamaly, N., Kalber, T., Thanou, M., Bell, J.D. and Miller, A.D. 2009. Folate receptor targeted bimodal liposomes for tumor magnetic resonance imaging. Bioconjugate Chemistry. 20 (4), pp. 648-655.

Neonatal intrahepatocellular lipid
Thomas, E.L., Uthaya, S.N., Vasu, V., McCarthy, J., McEwan, P., Hamilton, G., Bell, J.D. and Modi, N. 2008. Neonatal intrahepatocellular lipid. Archives of Disease in Childhood. Fetal and Neonatal Edition. 93 (5), pp. F382-F383.

Non-invasive means of measuring hepatic fat content
Mehta, S.R., Thomas, E.L., Bell, J.D., Johnston, D.G. and Taylor-Robinson, S.D. 2008. Non-invasive means of measuring hepatic fat content. World Journal of Gastroenterology. 14 (22), pp. 3476-3483.

Bimodal paramagnetic and fluorescent liposomes for cellular and tumor magnetic resonance imaging
Kamaly, N., Kalber, T., Ahmad, A., Oliver, M.H., So, P.W., Herlihy, A.H., Bell, J.D., Jorgensen, M.R. and Miller, A.D. 2008. Bimodal paramagnetic and fluorescent liposomes for cellular and tumor magnetic resonance imaging. Bioconjugate Chemistry. 19 (1), pp. 118-129.

Pioglitazone added to conventional lipid lowering treatment in familial combined hyperlipidaemia improves parameters of metabolic control: relation to liver, muscle and regional body fat content
Thomas, E.L., Potter, E., Tosi, I., Fitzpatrick, J., Hamilton, G., Amber, V., Hughs, R., North, C., Holvoet, P., Seed, M., Betteridge, D.J., Bell, J.D. and Naoumova, R.P. 2007. Pioglitazone added to conventional lipid lowering treatment in familial combined hyperlipidaemia improves parameters of metabolic control: relation to liver, muscle and regional body fat content. Atherosclerosis. 195 (1), pp. e181-e190.

The temporal sequence of gut peptide-central nervous system interactions tracked in vivo by magnetic resonance imaging
Kuo, Y.T., Parkinson, J.R.C., Chaudhri, O.B., Herlihy, A.H., So, P.W., Dhillo, W.S., Small, C.J., Bloom, S.R. and Bell, J.D. 2007. The temporal sequence of gut peptide-central nervous system interactions tracked in vivo by magnetic resonance imaging. Journal of Neuroscience. 27 (45), pp. 12341-12348.

Synthesis of a novel ‘smart’ bifunctional chelating agent 1-(2-[β,d-galactopyranosyloxy]ethyl)-7-(1-carboxy-3-[4-aminophenyl]propyl)-4,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododecane (Gal-PA-DO3A-NH2) and its Gd(III) complex
Wardle, N.J., Herlihy, A.H., So, P.W., Bell, J.D. and Bligh, S.W.A. 2007. Synthesis of a novel ‘smart’ bifunctional chelating agent 1-(2-[β,d-galactopyranosyloxy]ethyl)-7-(1-carboxy-3-[4-aminophenyl]propyl)-4,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododecane (Gal-PA-DO3A-NH2) and its Gd(III) complex. Bioorganic & medicinal chemistry. 15 (14), pp. 4714-4721.

The integration of lipid-sensing and anti-inflammatory effects: how the PPARs play a role in metabolic balance
Nunn, A.V.W., Bell, J.D. and Barter, P. 2007. The integration of lipid-sensing and anti-inflammatory effects: how the PPARs play a role in metabolic balance. Nuclear Receptor. 5 (1), pp. 1-12.

You have free access to this content Creatine supplements in patients with idiopathic inflammatory myopathies who are clinically weak after conventional pharmacologic treatment: Six-month, double-blind, randomized, placebo-controlled trial
Chung, Y.L., Alexanderson, H., Pipitone, N., Morrison, C., Dastmalchi, M., Ståhl-Hallengren, C., Richards, S., Thomas, E.L., Hamilton, G., Bell, J.D., Lundberg, I.E. and Scott, D.L. 2007. You have free access to this content Creatine supplements in patients with idiopathic inflammatory myopathies who are clinically weak after conventional pharmacologic treatment: Six-month, double-blind, randomized, placebo-controlled trial. Arthritis & Rheumatism. 57 (4), pp. 694-702.

Exercise training reduces fatty acid availability and improves the insulin sensitivity of glucose metabolism
Shojaee-Moradie, F., Baynes, K.C.R., Pentecost, C., Bell, J.D., Thomas, E.L., Jackson, N.C., Stolinski, M., Whyte, M., Lovell, D., Bowes, S.B., Gibney, J., Jones, R.H. and Umpleby, A.M. 2007. Exercise training reduces fatty acid availability and improves the insulin sensitivity of glucose metabolism. Diabetologia. 50 (2), pp. 404-413.

Impact of resistant starch on body fat patterning and central appetite regulation
So, P.W., Yu, W.S., Kuo, Y.T., Wasserfall, C., Goldstone, A.P., Bell, J.D. and Frost, G.S. 2007. Impact of resistant starch on body fat patterning and central appetite regulation. PLoS ONE. 2 (12), p. e1309.

Application of magnetic resonance methods to studies of gene therapy
So, P.W., Parkes, H.G. and Bell, J.D. 2007. Application of magnetic resonance methods to studies of gene therapy. Progress in Nuclear Magnetic Resonance Spectroscopy. 51 (1), pp. 49-62.

The application of in vivo MRI and MRS in phenomic studies of murine models of disease
So, P.W. and Bell, J.D. 2007. The application of in vivo MRI and MRS in phenomic studies of murine models of disease. in: Webb, G.A. (ed.) Modern magnetic resonance The Netherlands Springer. pp. 769-786

Manganese-enhanced magnetic resonance imaging (MEMRI) without compromise of the blood–brain barrier detects hypothalamic neuronal activity in vivo
Kuo, Y.T., Herlihy, A.H., So, P.W. and Bell, J.D. 2006. Manganese-enhanced magnetic resonance imaging (MEMRI) without compromise of the blood–brain barrier detects hypothalamic neuronal activity in vivo. NMR in Biomedicine. 19 (8), pp. 1028-1034.

Differential hypothalamic neuronal activation following peripheral injection of GLP-1 and oxyntomodulin in mice detected by manganese-enhanced magnetic resonance imaging
Chaudhri, O.B., Parkinson, J.R.C., Kuo, Y.T., Druce, M.R., Herlihy, A.H., Bell, J.D., Dhillo, W.S., Stanley, S.A., Ghatei, M.A. and Bloom, S.R. 2006. Differential hypothalamic neuronal activation following peripheral injection of GLP-1 and oxyntomodulin in mice detected by manganese-enhanced magnetic resonance imaging. Biochemical and Biophysical Research Communications. 350 (2), pp. 298-306.

Determinants of adiposity during preweaning postnatal growth in appropriately grown and growth-restricted term infants
Modi, N., Thomas, E.L., Harrington, T.A.M., Uthaya, S.N., Doré, C.J. and Bell, J.D. 2006. Determinants of adiposity during preweaning postnatal growth in appropriately grown and growth-restricted term infants. Pediatric Research. 60 (3), pp. 345-348.

Critical role for peptide YY in protein-mediated satiation and body-weight regulation
Batterham, R.L., Heffron, H., Kapoor, S., Chivers, J.E., Chandarana, K., Herzog, H., le Roux, C.W., Thomas, E.L., Bell, J.D. and Withers, D.J. 2006. Critical role for peptide YY in protein-mediated satiation and body-weight regulation. Cell Metabolism. 4 (3), pp. 223-233.

Effect of nutritional counselling on hepatic, muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease
Thomas, E.L., Brynes, A.E., Hamilton, G., Patel, N., Spong, A., Goldin, R.D., Frost, G.S., Bell, J.D. and Taylor-Robinson, S.D. 2006. Effect of nutritional counselling on hepatic, muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease. World Journal of Gastroenterology. 12 (36), pp. 5813-5819.

Intra-cellular fat accumulation: mechanisms and implications for health
Thomas, E.L. and Bell, J.D. 2006. Intra-cellular fat accumulation: mechanisms and implications for health. International Journal of Body Composition Research. 4 (1), pp. 27-37.

MAGfect: a novel liposome formulation for MRI labelling and visualization of cells
Oliver, M.H., Ahmad, A., Kamaly, N., Perouzel, E., Caussin, A., Keller, M., Herlihy, A.H., Bell, J.D., Miller, A.D. and Jorgensen, M.R. 2006. MAGfect: a novel liposome formulation for MRI labelling and visualization of cells. Organic and Biomolecular Chemistry. 4 (18), pp. 3489-3497.

Muscle metabolites, detected in urine by proton spectroscopy, correlate with disease damage in juvenile idiopathic inflammatory myopathies
Chung, Y.L., Rider, L.G., Bell, J.D., Summers, R.M., Zemel, L.S., Rennebohm, R.M., Passo, M.H., Hicks, J., Miller, F.W. and Scott, D.L. 2005. Muscle metabolites, detected in urine by proton spectroscopy, correlate with disease damage in juvenile idiopathic inflammatory myopathies. Arthritis & Rheumatology. 53 (4), pp. 565-570.

Generic method for imaging transgene expression
So, P.W., Hotee, S., Herlihy, A.H. and Bell, J.D. 2005. Generic method for imaging transgene expression. Magnetic Resonance in Medicine. 54 (1), pp. 218-221.

Adiposity induced by adenovirus 5 inoculation
So, P.W., Herlihy, A.H. and Bell, J.D. 2005. Adiposity induced by adenovirus 5 inoculation. International Journal of Obesity. 29 (6), pp. 603-606.

Excess visceral and hepatic adipose tissue in Turner syndrome determined by magnetic resonance imaging: estrogen deficiency associated with hepatic adipose content
Ostberg, J.E., Thomas, E.L., Hamilton, G., Attar, M.J.H., Bell, J.D. and Conway, G.S. 2005. Excess visceral and hepatic adipose tissue in Turner syndrome determined by magnetic resonance imaging: estrogen deficiency associated with hepatic adipose content. Journal of Clinical Endocrinology and Metabolism. 90 (5), pp. 2631-2635.

In vivo measurements of T1 relaxation times in mouse brain associated with different modes of systemic administration of manganese chloride
Kuo, Y.T., Herlihy, A.H., So, P.W., Bhakoo, K.K. and Bell, J.D. 2005. In vivo measurements of T1 relaxation times in mouse brain associated with different modes of systemic administration of manganese chloride. Journal of Magnetic Resonance Imaging. 21 (4), pp. 334-339.

The role of insulin receptor substrate 2 in hypothalamic and β cell function
Choudhury, A.I., Heffron, H., Smith, M.A., Al-Qassab, H., Xu, A.W., Selman, C., Simmgen, M., Clements, M., Claret, M., MacColl, G., Bedford, D.C., Hisadome, K., Diakonov, I., Moosajee, V., Bell, J.D., Speakman, J.R., Batterham, R.L., Barsh, G.S., Ashford, M.L.J. and Withers, D.J. 2005. The role of insulin receptor substrate 2 in hypothalamic and β cell function. Journal of Clinical Investigation. 115 (4), pp. 940-950.

Altered adiposity after extremely preterm birth
Uthaya, S.N., Thomas, E.L., Hamilton, G., Doré, C.J., Bell, J.D. and Modi, N. 2005. Altered adiposity after extremely preterm birth. Pediatric Research. 57 (2), pp. 211-215.

Phosphorus-31 brain MR spectroscopy in women during and after pregnancy compared with nonpregnant control subjects
Holdcroft, A., Hall, L., Hamilton, G., Counsell, S.J., Bydder, G.M. and Bell, J.D. 2005. Phosphorus-31 brain MR spectroscopy in women during and after pregnancy compared with nonpregnant control subjects. American Journal of Neuroradiology. 26 (2), pp. 352-356.

Veganism and its relationship with insulin resistance and intramyocellular lipid
Goff, L.M., Bell, J.D., So, P.W., Dornhorst, A. and Frost, G.S. 2005. Veganism and its relationship with insulin resistance and intramyocellular lipid. European Journal of Clinical Nutrition. 59 (2), pp. 291-298.

Hepatic triglyceride content and its relation to body adiposity: a magnetic resonance imaging and proton magnetic resonance spectroscopy study
Thomas, E.L., Hamilton, G., Patel, N., O'Dwyer, R., Doré, C.J., Goldin, R.D., Bell, J.D. and Taylor-Robinson, S.D. 2005. Hepatic triglyceride content and its relation to body adiposity: a magnetic resonance imaging and proton magnetic resonance spectroscopy study. Gut. 54 (1), pp. 122-127.

Contrast enhancement of short T2 tissues using ultrashort TE (UTE) pulse sequences
Robson, M.D., Gatehouse, P.D., So, P.W., Bell, J.D. and Bydder, G.M. 2004. Contrast enhancement of short T2 tissues using ultrashort TE (UTE) pulse sequences. Clinical Radiology. 59 (8), pp. 720-726.

Links Familial partial lipodystrophy associated with compound heterozygosity for novel mutations in the LMNA gene
Savage, D.B., McFarlane, I.A., Barroso, I., Soos, M.A., Powlson, A., Thomas, E.L., Bell, J.D., Scobie, I., Belchetz, P.E., Kelly, W.F., Halsall, D.J., Schafer, A.J. and O’Rahilly, S. 2004. Links Familial partial lipodystrophy associated with compound heterozygosity for novel mutations in the LMNA gene. Diabetologia. 47 (4), pp. 753-756.

Elevated fasting plasma ghrelin in Prader-Willi Syndrome adults is not solely explained by their reduced visceral adiposity and insulin resistance
Goldstone, A.P., Thomas, E.L., Brynes, A.E., Castroman, G., Edwards, R., Ghatei, M.A., Frost, G.S., Holland, A., Grossman, A.B., Korbonits, M., Bloom, S.R. and Bell, J.D. 2004. Elevated fasting plasma ghrelin in Prader-Willi Syndrome adults is not solely explained by their reduced visceral adiposity and insulin resistance. Journal of Clinical Endocrinology and Metabolism. 89 (4), pp. 1718-1726.

Distribution of adipose tissue in the newborn
Harrington, T.A.M., Thomas, E.L., Modi, N., Frost, G.S. and Bell, J.D. 2004. Distribution of adipose tissue in the newborn. Pediatric Research. 55 (3), pp. 437-441.

Adipose tissue magnetic resonance imaging in the newborn
Uthaya, S.N., Bell, J.D. and Modi, N. 2004. Adipose tissue magnetic resonance imaging in the newborn. Hormone Research. 62 (sup.3), pp. 143-148.

Nuclear receptor corepressor RIP140 regulates fat accumulation
Leonardsson, G., Steel, J.H., Christian, M., Pocock, V., Milligan, S., Bell, J.D., So, P.W., Medina-Gomez, G., Vidal-Puig, A., White, R. and Parker, M.G. 2004. Nuclear receptor corepressor RIP140 regulates fat accumulation. Proceedings of the National Academy of Sciences. 101 (22), pp. 8437-8442.

The application of magnetic resonance imaging and spectroscopy to gene therapy
Bhakoo, K.K., Bell, J.D., Cox, I.J. and Taylor-Robinson, S.D. 2004. The application of magnetic resonance imaging and spectroscopy to gene therapy. in: Ashkenazi, A., Wells, J.A. and Yuan, J. (ed.) Methods in enzymology Elsevier.

N-acetyl aspartate estimation: a potential method for determining neuronal loss in the transmissible spongiform encephalopathies
Chung, Y.L., Barr, J., Bhakoo, K.K., Williams, S.C.R., Bell, J.D. and Fraser, J.R. 2003. N-acetyl aspartate estimation: a potential method for determining neuronal loss in the transmissible spongiform encephalopathies. Neuropathology and Applied Neurobiology. 29 (5), pp. 445-450.

Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-γ
Savage, D.B., Tan, G.D., Acerini, C.L., Jebb, S.A., Agostini, M., Gurnell, M., Williams, R.L., Umpleby, A.M., Thomas, E.L., Bell, J.D., Dixon, A.K., Dunne, F., Boiani, R., Cinti, S., Vidal-Puig, A., Karpe, F., Chatterjee, V.K.K. and O'Rahilly, S. 2003. Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-γ. Diabetes. 52 (4), p. 910.

Carbohydrate-induced manipulation of insulin sensitivity independently of intramyocellular lipids
Goff, L.M., Frost, G.S., Hamilton, G., Thomas, E.L., Dhillo, W.S., Dornhorst, A. and Bell, J.D. 2003. Carbohydrate-induced manipulation of insulin sensitivity independently of intramyocellular lipids. British Journal of Nutrition. 89 (3), pp. 365-375.

Influence of undersampling on magnetic resonance imaging measurements of intra-abdominal adipose tissue
Thomas, E.L. and Bell, J.D. 2003. Influence of undersampling on magnetic resonance imaging measurements of intra-abdominal adipose tissue. International Journal of Obesity. 27 (2), pp. 211-218.

Urinary levels of creatine and other metabolites in the assessment of polymyositis and dermatomyositis
Chung, Y.L., Wassif, W.S., Bell, J.D., Hurley, M. and Scott, D.L. 2003. Urinary levels of creatine and other metabolites in the assessment of polymyositis and dermatomyositis. Rheumatology. 42 (2), pp. 298-303.

Hypothalamic neuropeptides and regulation of fat mass in Prader-Willi syndrome
Goldstone, A.P., Unmehopa, U.A., Thomas, E.L., Brynes, A.E., Bell, J.D., Frost, G.S., Ghatei, M.A., Holland, A., Bloom, S.R. and Swaab, D.F. 2003. Hypothalamic neuropeptides and regulation of fat mass in Prader-Willi syndrome. in: Eiholzer, U., l’Allemand, D. and Zipf, W.B. (ed.) Prader-Willi syndrome as a model for obesity: international symposium, Zurich, October 18-19, 2002 Karger Medical and Scientific Publishers. pp. 31-43

Letter: Digenic inheritance of severe insulin resistance in a human pedigree
Savage, D.B., Agostini, M., Barroso, I., Gurnell, M., Luan, J.A., Meirhaeghe, A., Harding, A.H., Ihrke, G., Rajanayagam, O., Soos, M.A., George, S., Birger, D., Thomas, E.L., Bell, J.D., Meera, K., Ross, R.J., Vidal-Puig, A., Wareham, N.J., O'Rahilly, S., Chatterjee, V.K.K. and Schafer, A.J. 2002. Letter: Digenic inheritance of severe insulin resistance in a human pedigree. Nature Genetics. 31 (4), pp. 379-384.

Resting metabolic rate, plasma leptin concentrations, leptin receptor expression, and adipose tissue measured by whole-body magnetic resonance imaging in women with Prader-Willi syndrome
Goldstone, A.P., Brynes, A.E., Thomas, E.L., Bell, J.D., Frost, G.S., Holland, A., Ghatei, M.A. and Bloom, S.R. 2002. Resting metabolic rate, plasma leptin concentrations, leptin receptor expression, and adipose tissue measured by whole-body magnetic resonance imaging in women with Prader-Willi syndrome. American Journal of Clinical Nutition. 75 (3), pp. 468-475.

Fast and reproducible method for the direct quantitation of adipose tissue in newborn infants
Harrington, T.A.M., Thomas, E.L., Modi, N., Frost, G.S., Coutts, G.A. and Bell, J.D. 2002. Fast and reproducible method for the direct quantitation of adipose tissue in newborn infants. Lipids. 37 (1), pp. 95-100.

Evidence for altered hepatic gluconeogenesis in patients with cirrhosis using in vivo 31-phosphorus magnetic resonance spectroscopy
Changani, K.K., Jalan, R., Cox, I.J., Ala-Korpela, M., Bhakoo, K.K., Taylor-Robinson, S.D. and Bell, J.D. 2001. Evidence for altered hepatic gluconeogenesis in patients with cirrhosis using in vivo 31-phosphorus magnetic resonance spectroscopy. Gut. 49 (4), pp. 557-564.

Visceral adipose tissue and metabolic complications of obesity are reduced in Prader-Willi syndrome female adults: evidence for novel influences on body fat distribution
Goldstone, A.P., Thomas, E.L., Brynes, A.E., Bell, J.D., Frost, G.S., Saeed, N., Hajnal, J.V., Howard, J.K., Holland, A. and Bloom, S.R. 2001. Visceral adipose tissue and metabolic complications of obesity are reduced in Prader-Willi syndrome female adults: evidence for novel influences on body fat distribution. Journal of Clinical Endocrinology and Metabolism. 86 (9), pp. 4330-4338.

In vivo evaluation of the effects of continuous exercise on skeletal muscle triglycerides in trained humans
Rico-Sanz, J., Moosavi, M., Thomas, E.L., McCarthy, J., Coutts, G.A., Saeed, N. and Bell, J.D. 2000. In vivo evaluation of the effects of continuous exercise on skeletal muscle triglycerides in trained humans. Lipids. 35 (12), pp. 1313-1315.

Investigation of human low-density lipoprotein by 1H nuclear magnetic resonance spectroscopy:  mobility of phosphatidylcholine and sphingomyelin headgroups characterizes the surface layer
Murphy, H.C., Burns, S.P., White, J.J., Bell, J.D. and Iles, R.A. 2000. Investigation of human low-density lipoprotein by 1H nuclear magnetic resonance spectroscopy:  mobility of phosphatidylcholine and sphingomyelin headgroups characterizes the surface layer. Biochemistry. 39 (32), pp. 9763-9770.

Bioenergetic targeting during organ preservation: 31P magnetic resonance spectroscopy investigations into the use of fructose to sustain hepatic ATP turnover during cold hypoxia in porcine livers
Changani, K.K., Fuller, B.J., Bell, J.D., Taylor-Robinson, S.D. and Davidson, B.R. 2000. Bioenergetic targeting during organ preservation: 31P magnetic resonance spectroscopy investigations into the use of fructose to sustain hepatic ATP turnover during cold hypoxia in porcine livers. Cryobiology. 41 (1), pp. 72-87.

Assessing gene expression in vivo: magnetic resonance imaging and spectroscopy
Bell, J.D. and Taylor-Robinson, S.D. 2000. Assessing gene expression in vivo: magnetic resonance imaging and spectroscopy. Gene Therapy. 7 (15), pp. 1259-1264.

Preferential loss of visceral fat following aerobic exercise, measured by magnetic resonance imaging
Thomas, E.L., Brynes, A.E., McCarthy, J., Goldstone, A.P., Hajnal, J.V., Saeed, N., Frost, G.S. and Bell, J.D. 2000. Preferential loss of visceral fat following aerobic exercise, measured by magnetic resonance imaging. Lipids. 35 (7), pp. 769-776.

Increased availability of central benzodiazepine receptors in patients with chronic hepatic encephalopathy and alcohol related cirrhosis
Jalan, R., Turjanski, N., Taylor-Robinson, S.D., Koepp, M.J., Richardson, M.P., Wilson, J.A., Bell, J.D. and Brooks, D.J. 2000. Increased availability of central benzodiazepine receptors in patients with chronic hepatic encephalopathy and alcohol related cirrhosis. Gut. 46 (4), pp. 546-552.

Cortical dysfunction in non-demented Parkinson's disease patients: A combined 31P-MRS and 18FDG-PET study
Hu, M.T.M., Taylor-Robinson, S.D., Chaudhuri, K.R., Bell, J.D., Labbé, C., Cunningham, V.J., Koepp, M.J., Hammers, A., Morris, R.G., Turjanski, N. and Brooks, D.J. 2000. Cortical dysfunction in non-demented Parkinson's disease patients: A combined 31P-MRS and 18FDG-PET study. Brain. 123 (2), pp. 340-352.

Conflicting MRI signals from gliosis and neuronal vacuolation in prion diseases
Chung, Y.L., Williams, A., Ritchie, D., Williams, S.C.R., Changani, K.K., Hope, J. and Bell, J.D. 1999. Conflicting MRI signals from gliosis and neuronal vacuolation in prion diseases. NeuroReport. 10 (17), pp. 3471-3477.

Cerebral proton and phosphorus-31 magnetic resonance spectroscopy in patients with subclinical hepatic encephalopathy
Taylor-Robinson, S.D., Buckley, C., Changani, K.K., Hodgson, H.J.F. and Bell, J.D. 1999. Cerebral proton and phosphorus-31 magnetic resonance spectroscopy in patients with subclinical hepatic encephalopathy. Liver. 19 (5), pp. 389-398.

Improved preservation solutions for organ storage: a dynamic study of hepatic metabolism
Changani, K.K., Fuller, B.J., Bell, J.D., Taylor-Robinson, S.D., Moore, D.P. and Davidson, B.R. 1999. Improved preservation solutions for organ storage: a dynamic study of hepatic metabolism. Transplantation. 68 (3), pp. 345-355.

Evidence for cortical dysfunction in clinically non-demented patients with Parkinson’s disease: a proton MR spectroscopy study
Hu, M.T.M., Taylor-Robinson, S.D., Chaudhuri, K.R., Bell, J.D., Morris, R.G., Clough, C., Brooks, D.J. and Turjanski, N. 1999. Evidence for cortical dysfunction in clinically non-demented patients with Parkinson’s disease: a proton MR spectroscopy study. Journal of Neurology, Neurosurgery, and Psychiatry. 67 (1), pp. 20-26.

Relation of triglyceride stores in skeletal muscle cells to central obesity and insulin sensitivity in European and South Asian men
Forouhi, N.G., Jenkinson, G., Thomas, E.L., Mullick, S., Mierisová, Ŝ., Bhonsle, U., McKeigue, P.M. and Bell, J.D. 1999. Relation of triglyceride stores in skeletal muscle cells to central obesity and insulin sensitivity in European and South Asian men. Diabetologia. 42 (8), pp. 932-935.

Brain bioenergetics in murine models of scrapie using in vivo 31P magnetic resonance spectroscopy
Chung, Y.L., Williams, S.C.R., Hope, J. and Bell, J.D. 1999. Brain bioenergetics in murine models of scrapie using in vivo 31P magnetic resonance spectroscopy. NeuroReport. 10 (9), pp. 1899-1901.

Incorporation of metabolite prior knowledge for data analysis: biochemical implications of dynamic 31P NMR ex vivo pig liver studies
Changani, K.K., Ala-Korpela, M., Fuller, B.J., Mierisová, Ŝ., Bryant, D.J., Taylor-Robinson, S.D., Davidson, B.R. and Bell, J.D. 1999. Incorporation of metabolite prior knowledge for data analysis: biochemical implications of dynamic 31P NMR ex vivo pig liver studies. NMR in Biomedicine. 12 (4), pp. 197-204.

Angiotensin-converting-enzyme gene insertion/deletion polymorphism and response to physical training
Montgomery, H., Clarkson, P., Barnard, M.L., Bell, J.D., Brynes, A.E., Hajnal, J.V., Hemingway, H., Mercer, D., Jarman, P., Marshall, R., Prasad, K., Rayson, M., Saeed, N., Thomas, E.L., Jubb, M., World, M., Dollery, C., Talmud, P. and Humphries, S.E. 1999. Angiotensin-converting-enzyme gene insertion/deletion polymorphism and response to physical training. The Lancet. 353 (9152), pp. 541-545.

Relation between proton magnetic resonance spectroscopy within 18 hours of birth asphyxia and neurodevelopment at 1 year of age
Hanrahan, J.D., Cox, I.J., Azzopardi, D., Cowan, F.M., Sargentoni, J., Bell, J.D., Bryant, D.J. and Edwards, A.D. 1999. Relation between proton magnetic resonance spectroscopy within 18 hours of birth asphyxia and neurodevelopment at 1 year of age. Developmental Medicine & Child Neurology. 41 (2), pp. 76-82.

Body fat metabolism: observation by MR imaging and spectroscopy
Thomas, E.L. and Bell, J.D. 1999. Body fat metabolism: observation by MR imaging and spectroscopy. in: Young, I.R. (ed.) Magnetic resonance imaging and spectroscopy in medicine and biology Wiley.

Diversity in levels of intracellular total creatine and triglycerides in human skeletal muscles observed by 1H-MRS
Rico-Sanz, J., Thomas, E.L., Jenkinson, G., Mierisová, Ŝ., Iles, R.A. and Bell, J.D. 1999. Diversity in levels of intracellular total creatine and triglycerides in human skeletal muscles observed by 1H-MRS. Journal of Applied Physiology. 87 (6), pp. 2068-2072.

Magnetic resonance: in-vivo NMR, applications – other nuclei
Bell, J.D., Thomas, E.L. and Changani, K.K. 1999. Magnetic resonance: in-vivo NMR, applications – other nuclei. in: Lindon, J. (ed.) Encyclopedia of spectroscopy and spectrometry London Academic Press.

Metabolic changes underlying 31P MR spectral alterations in human hepatic tumours
Bell, J.D. and Bhakoo, K.K. 1998. Metabolic changes underlying 31P MR spectral alterations in human hepatic tumours. NMR in Biomedicine. 11 (7), pp. 354-359.

Critical assessment of in vivo13C NMR spectroscopy and gas–liquid chromatography in the study of adipose tissue composition
Thomas, E.L., Cunnane, S.C. and Bell, J.D. 1998. Critical assessment of in vivo13C NMR spectroscopy and gas–liquid chromatography in the study of adipose tissue composition. NMR in Biomedicine. 11 (6), pp. 290-296.

Evaluation of the stability of the proton chemical shifts of some metabolites other than water during thermal cycling of normal human muscle tissue
Young, I.R., Bell, J.D., Hajnal, J.V., Jenkinson, G. and Ling, J. 1998. Evaluation of the stability of the proton chemical shifts of some metabolites other than water during thermal cycling of normal human muscle tissue. Journal of Magnetic Resonance Imaging. 8 (5), pp. 1114-1118.

Persistent increase in cerebral lactate concentration after birth asphyxia
Hanrahan, J.D., Cox, I.J., Edwards, A.D., Cowan, F.M., Sargentoni, J., Bell, J.D., Bryant, D.J., Rutherford, M.A. and Azzopardi, D. 1998. Persistent increase in cerebral lactate concentration after birth asphyxia. Pediatric Research. 44 (3), pp. 304-311.

Intracellular and extracellular skeletal muscle triglyceride metabolism during alternating intensity exercise in humans
Rico-Sanz, J., Hajnal, J.V., Thomas, E.L., Mierisová, Ŝ., Ala-Korpela, M. and Bell, J.D. 1998. Intracellular and extracellular skeletal muscle triglyceride metabolism during alternating intensity exercise in humans. Journal of Physiology. 510 (2), pp. 615-622.

Non-invasive metabolic assessment of human donor livers: metabolite assignment in 31P magnetic resonance spectroscopy
Changani, K.K., Taylor-Robinson, S.D., Bell, J.D., Fuller, B.J. and Davidson, B.R. 1998. Non-invasive metabolic assessment of human donor livers: metabolite assignment in 31P magnetic resonance spectroscopy. Transplantation. 65 (11), pp. 1526-1527.

Human gene for physical performance
Montgomery, H., Marshall, R., Hemingway, H., Myerson, S., Clarkson, P., Dollery, C., Hayward, M., Holliman, D.E., Jubb, M., World, M., Thomas, E.L., Brynes, A.E., Saeed, N., Barnard, M.L., Bell, J.D., Prasad, K., Rayson, M., Talmud, P. and Humphries, S.E. 1998. Human gene for physical performance. Nature. 393 (6682), pp. 221-222.

13C-Glycogen deposition during pregnancy in the rat following routine meal feeding
Changani, K.K., Bell, J.D. and Iles, R.A. 1998. 13C-Glycogen deposition during pregnancy in the rat following routine meal feeding. Biochimica et Biophysica Acta: general subjects. 1380 (2), pp. 198-208.

Magnetic resonance imaging of total body fat
Thomas, E.L., Saeed, N., Hajnal, J.V., Brynes, A.E., Goldstone, A.P., Frost, G.S. and Bell, J.D. 1998. Magnetic resonance imaging of total body fat. Journal of Applied Physiology. 85 (5), pp. 1778-1785.

A comparison of ATP recovery or phosphomonoester/inorganic phosphate ratio to assess metabolic activity in liver at hypothermia: a 31P NMR study
Changani, K.K., Davidson, B.R., Bell, J.D., Taylor-Robinson, S.D. and Fuller, B.J. 1998. A comparison of ATP recovery or phosphomonoester/inorganic phosphate ratio to assess metabolic activity in liver at hypothermia: a 31P NMR study. CryoLetters. 19, pp. 183-188.

Enhanced energy metabolism at hypothermia following addition of a prostacyclin derivative in porcine liver
Changani, K.K., Davidson, B.R., Bell, J.D., Taylor-Robinson, S.D. and Fuller, B.J. 1998. Enhanced energy metabolism at hypothermia following addition of a prostacyclin derivative in porcine liver. CryoLetters. 19, pp. 131-140.

Depression of liver mitochondrial complex II-linked respiration following cooling: beneficial effects of using a prostacyclin analogue during hypothermia
Changani, K.K., Bell, J.D., Brooks, K.J., Fuller, B.J., Taylor-Robinson, S.D., Davidson, B.R., Brookes, P.S. and Bates, T.E. 1998. Depression of liver mitochondrial complex II-linked respiration following cooling: beneficial effects of using a prostacyclin analogue during hypothermia. CryoLetters. 19, pp. 71-78.

Assessment of quantitative artificial neural network analysis in a metabolically dynamic ex vivo31p NMR pig liver study
Ala-Korpela, M., Changani, K.K., Hiltunen, Y., Bell, J.D., Fuller, B.J., Bryant, D.J., Taylor-Robinson, S.D. and Davidson, B.R. 1997. Assessment of quantitative artificial neural network analysis in a metabolically dynamic ex vivo31p NMR pig liver study. Magnetic Resonance in Medicine. 38 (5), pp. 840-844.

In vivo and in vitro hepatic 31P magnetic resonance spectroscopy and electron microscopy of the cirrhotic liver
Taylor-Robinson, S.D., Sargentoni, J., Bell, J.D., Saeed, N., Changani, K.K., Davidson, B.R., Rolles, K., Burroughs, A.K., Hodgson, H.J.F., Foster, C.S. and Cox, I.J. 1997. In vivo and in vitro hepatic 31P magnetic resonance spectroscopy and electron microscopy of the cirrhotic liver. Liver. 17 (4), pp. 198-209.

In vivo assessment of metabolic perturbations following alanine and glucagon administration using 31P-MRS in the rat
Changani, K.K., Barnard, M.L., Bell, J.D., Thomas, E.L., Williams, S.C.R., Bloom, S.R. and Iles, R.A. 1997. In vivo assessment of metabolic perturbations following alanine and glucagon administration using 31P-MRS in the rat. Biochimica et Biophysica Acta: general subjects. 1335 (3), pp. 290-304.

Noninvasive characterization of neonatal adipose tissue by 13C magnetic resonance spectroscopy
Thomas, E.L., Hanrahan, J.D., Ala-Korpela, M., Jenkinson, G., Azzopardi, D., Iles, R.A. and Bell, J.D. 1997. Noninvasive characterization of neonatal adipose tissue by 13C magnetic resonance spectroscopy. Lipids. 32 (6), pp. 645-651.

Evidence for distinct behaviour of phosphatidylcholine and sphingomyelin at the low density lipoprotein surface
Murphy, H.C., Ala-Korpela, M., White, J.J., Raoof, A., Bell, J.D., Barnard, M.L., Burns, S.P. and Iles, R.A. 1997. Evidence for distinct behaviour of phosphatidylcholine and sphingomyelin at the low density lipoprotein surface. Biochemical and Biophysical Research Communications. 234 (3), pp. 733-737.

Non-invasive assessment of ATP regeneration potential of the preserved donor liver
Changani, K.K., Fuller, B.J., Bryant, D.J., Bell, J.D., Ala-Korpela, M., Taylor-Robinson, S.D., Moore, D.P. and Davidson, B.R. 1997. Non-invasive assessment of ATP regeneration potential of the preserved donor liver. Journal of Hepatology. 26 (2), pp. 336-342.

The application of NMR spectroscopy to the study of apoptosis
Bhakoo, K.K. and Bell, J.D. 1997. The application of NMR spectroscopy to the study of apoptosis. Cellular and Molecular Biology. 43 (5), pp. 621-629.

Changes in adipose tissue composition in malnourished patients before and after liver transplantation: A carbon-13 magnetic resonance spectroscopy and gas-liquid chromatography study
Thomas, E.L., Taylor-Robinson, S.D., Barnard, M.L., Frost, G.S., Sargentoni, J., Davidson, B.R., Cunnane, S.C. and Bell, J.D. 1997. Changes in adipose tissue composition in malnourished patients before and after liver transplantation: A carbon-13 magnetic resonance spectroscopy and gas-liquid chromatography study. Hepatology. 25 (1), pp. 178-183.

Metabolic changes associated with vacuolation in murine models of scrapie using in vitro 1H-NMR spectroscopy
Chung, Y.L., Williams, A., Chong, A., Hope, J., Williams, S.C.R. and Bell, J.D. 1996. Metabolic changes associated with vacuolation in murine models of scrapie using in vitro 1H-NMR spectroscopy. NMR in Biomedicine. 9 (8), pp. 359-363.

Hepatic nucleotide triphosphate regeneration following a period of brief hypothermic reperfusion in the pig model: an in vitro 31P-NMR study
Changani, K.K., Fuller, B.J., Bell, J.D., Bryant, D.J., Moore, D.P., Taylor-Robinson, S.D. and Davidson, B.R. 1996. Hepatic nucleotide triphosphate regeneration following a period of brief hypothermic reperfusion in the pig model: an in vitro 31P-NMR study. Transplantation. 62 (6), pp. 787-793.

Characterisation of secondary metabolites associated with neutrophil apoptosis
Nunn, A.V.W., Barnard, M.L., Bhakoo, K.K., Murray, J., Chilvers, E.J. and Bell, J.D. 1996. Characterisation of secondary metabolites associated with neutrophil apoptosis. FEBS Letters. 392 (3), pp. 295-298.

Effects of n-3 fatty acids on the NMR profile of plasma lipoproteins
Bell, J.D., Barnard, M.L., Parkes, H.G., Thomas, E.L., Brennan, C.H., Cunnane, S.C. and Dagnelie, P.C. 1996. Effects of n-3 fatty acids on the NMR profile of plasma lipoproteins. The Journal of Lipid Research. 37 (8), pp. 1664-1674.

Automated feature extraction for the classification of human in vivo13C NMR spectra using statistical pattern recognition and wavelets
Tate, A.R., Watson, D., Eglen, S., Arvanitis, T.N., Thomas, E.L. and Bell, J.D. 1996. Automated feature extraction for the classification of human in vivo13C NMR spectra using statistical pattern recognition and wavelets. Magnetic Resonance in Medicine. 35 (6), pp. 834-840.

Development of a rapid and efficient magnetic resonance imaging technique for analysis of body fat distribution
Barnard, M.L., Schwieso, J.E., Thomas, E.L., Bell, J.D., Saeed, N., Frost, G.S., Bloom, S.R. and Hajnal, J.V. 1996. Development of a rapid and efficient magnetic resonance imaging technique for analysis of body fat distribution. NMR in Biomedicine. 9 (4), pp. 156-164.

Cerebral metabolism within 18 hours of birth asphyxia: a proton magnetic resonance spectroscopy study
Hanrahan, J.D., Sargentoni, J., Azzopardi, D., Manji, K., Cowan, F.M., Rutherford, M.A., Cox, I.J., Bell, J.D., Bryant, D.J. and Edwards, A.D. 1996. Cerebral metabolism within 18 hours of birth asphyxia: a proton magnetic resonance spectroscopy study. Paediatric Research. 39 (4), pp. 584-590.

Anin vivo 13C magnetic resonance spectroscopic study of the relationship between diet and adipose tissue composition
Thomas, E.L., Frost, G.S., Barnard, M.L., Bryant, D.J., Taylor-Robinson, S.D., Simbrunner, J., Coutts, G.A., Burl, M., Bloom, S.R., Sales, K.D. and Bell, J.D. 1996. Anin vivo 13C magnetic resonance spectroscopic study of the relationship between diet and adipose tissue composition. Lipids. 31 (2), pp. 145-151.

Hepatic phosphorus-31 magnetic resonance spectroscopy in primary biliary cirrhosis and its relation to prognostic models
Jalan, R., Sargentoni, J., Coutts, G.A., Bell, J.D., Rolles, K., Burroughs, A.K. and Taylor-Robinson, S.D. 1996. Hepatic phosphorus-31 magnetic resonance spectroscopy in primary biliary cirrhosis and its relation to prognostic models. Gut. 39 (1), pp. 141-146.

Body fluid spectroscopic studies
Bell, J.D. and Sadler, P.J. 1996. Body fluid spectroscopic studies. in: Grant, D.M. and Harris, R.K. (ed.) Encyclopedia of nuclear magnetic resonance Chichester Wiley.

Dietary changes: observation by NMR spectroscopy
Bell, J.D. and Barnard, M.L. 1996. Dietary changes: observation by NMR spectroscopy. in: Grant, D.M. and Harris, R.K. (ed.) Encyclopedia of nuclear magnetic resonance Chichester Wiley.

Artificial neural network analysis of 1H NMR spectroscopic data from human plasma
Ala-Korpela, M., Hiltunen, Y. and Bell, J.D. 1996. Artificial neural network analysis of 1H NMR spectroscopic data from human plasma. Anticancer Research. 16 (3B), pp. 1473-1478.

Cirrhosis of the human liver: an in vitro 31P nuclear magnetic resonance study
Taylor-Robinson, S.D., Thomas, E.L., Sargentoni, J., Marcus, C.D., Davidson, B.R. and Bell, J.D. 1995. Cirrhosis of the human liver: an in vitro 31P nuclear magnetic resonance study. Biochimica et Biophysica Acta: Molecular Basis of Disease. 1272 (2), pp. 113-118.

Quantification of biomedical NMR data using artificial neural network analysis: lipoprotein lipid profiles from 1H NMR data of human plasma
Ala-Korpela, M., Hiltunen, Y. and Bell, J.D. 1995. Quantification of biomedical NMR data using artificial neural network analysis: lipoprotein lipid profiles from 1H NMR data of human plasma. NMR in Biomedicine. 8 (6), pp. 235-244.

MRI assessment of the blood-brain barrier in a hamster model of scrapie
Chung, Y.L., Williams, A., Beech, J.S., Williams, S.C.R., Bell, J.D., Cox, I.J. and Hope, J. 1995. MRI assessment of the blood-brain barrier in a hamster model of scrapie. Neurodegeneration. 4 (2), pp. 203-207.

Effect of functional grade and etiology on in vivo hepatic phosphorus-31 magnetic resonance spectroscopy in cirrhosis: Biochemical basis of spectral appearances
Menon, D.K., Sargentoni, J., Taylor-Robinson, S.D., Bell, J.D., Cox, I.J., Bryant, D.J., Coutts, G.A., Rolles, K., Burroughs, A.K. and Morgan, M.Y. 1995. Effect of functional grade and etiology on in vivo hepatic phosphorus-31 magnetic resonance spectroscopy in cirrhosis: Biochemical basis of spectral appearances. Hepatology. 21 (2), pp. 417-427.

Cerebral 31P MRS in patients with chronic hepatic encephalopathy
Taylor-Robinson, S.D., Bell, J.D., Sargentoni, J., Bryant, D.J., Mallalieu, R.J. and Morgan, M.Y. 1995. Cerebral 31P MRS in patients with chronic hepatic encephalopathy. in: Capocaccia, L., Merli, M. and Riggio, O. (ed.) Advances in hepatic encephalopathy and metabolic nitrogen exchange Hants CRC Press.

Cerebral Phosphorus-31 magnetic resonance spectroscopy in patients with chronic hepatic encephalopathy
Taylor-Robinson, S.D., Sargentoni, J., Mallalieu, R.J., Bell, J.D., Bryant, D.J., Coutts, G.A. and Morgan, M.Y. 1994. Cerebral Phosphorus-31 magnetic resonance spectroscopy in patients with chronic hepatic encephalopathy. Hepatology. 20 (5), pp. 1173-1178.

Utilization of uniformly labeled 13C-polyunsaturated fatty acids in the synthesis of long-chain fatty acids and cholesterol accumulating in the neonatal rat brain
Cunnane, S.C., Williams, S.C.R., Bell, J.D., Brookes, S., Craig, K., Iles, R.A. and Crawford, M.A. 1994. Utilization of uniformly labeled 13C-polyunsaturated fatty acids in the synthesis of long-chain fatty acids and cholesterol accumulating in the neonatal rat brain. Journal of Neurochemistry. 62 (6), pp. 2429-2436.

Effect of fish oil on cancer cachexia and host liver metabolism in rats with prostate tumours
Dagnelie, P.C., Bell, J.D., Williams, S.C.R., Bates, T.E., Abel, P.D. and Foster, C.S. 1994. Effect of fish oil on cancer cachexia and host liver metabolism in rats with prostate tumours. Lipids. 29 (3), pp. 195-203.

NMR studies of body fluids and tissue extracts
Bell, J.D., Preece, N.E. and Parkes, H.G. 1994. NMR studies of body fluids and tissue extracts. in: Gillies, R. (ed.) Nuclear magnetic resonance in physiology and biomedicine Oxford Pergamon.

In vivo fluorine-19 magnetic resonance spectroscopy of cerebral halothane in postoperative patients: preliminary results
Menon, D.K., Lockwood, G.G., Peden, C.J., Cox, I.J., Sargentoni, J., Bell, J.D., Coutts, G.A. and Whitwam, J.G. 1993. In vivo fluorine-19 magnetic resonance spectroscopy of cerebral halothane in postoperative patients: preliminary results. Magnetic Resonance in Medicine. 30 (6), pp. 680-684.

A 31P and 1H NMR investigation in vitro of normal and abnormal human liver
Bell, J.D., Cox, I.J., Sargentoni, J., Peden, C.J., Menon, D.K., Foster, C.S., Watanapa, P., Iles, R.A. and Urenjak, J. 1993. A 31P and 1H NMR investigation in vitro of normal and abnormal human liver. Biochimica et Biophysica Acta: Lipids and Lipid Metabolism. 1225 (1), pp. 71-77.

Altered phosphorylation status, phospholipid metabolism and gluconeogenesis in the host liver of rats with prostate cancer: a 31P magnetic resonance spectroscopy study
Dagnelie, P.C., Bell, J.D., Williams, S.C.R., Bates, T.E., Abel, P.D. and Foster, C.S. 1993. Altered phosphorylation status, phospholipid metabolism and gluconeogenesis in the host liver of rats with prostate cancer: a 31P magnetic resonance spectroscopy study. British Journal of Cancer. 67 (6), pp. 1303-1309.

The proton NMR spectrum in acute EAE: the significance of the change in the Cho:Cr ratio
Brenner, R.E., Munro, P.M.G., Williams, S.C.R., Bell, J.D., Barker, G.J., Landon, D.N., Hawkins, C.P. and McDonald, W.I. 1993. The proton NMR spectrum in acute EAE: the significance of the change in the Cho:Cr ratio. Magnetic Resonance in Medicine. 29 (6), pp. 737-745.

Effects of fish oil on phospholipid metabolism in human and rat liver studied by 31P NMR spectroscopy in vivo and in vitro
Dagnelie, P.C., Bell, J.D., Cox, I.J., Menon, D.K., Sargentoni, J., Coutts, G.A. and Williams, S.C.R. 1993. Effects of fish oil on phospholipid metabolism in human and rat liver studied by 31P NMR spectroscopy in vivo and in vitro. NMR in Biomedicine. 6 (2), pp. 157-162.

Potential of nuclear magnetic resonance spectroscopy for studies of N- fatty acid metabolism in plasma, liver and adipose tissues
Dagnelie, P.C., Bell, J.D., Barnard, M.L. and Williams, S.C.R. 1993. Potential of nuclear magnetic resonance spectroscopy for studies of N- fatty acid metabolism in plasma, liver and adipose tissues. in: Drevon, A., Baksaas, I. and Krokan, H.E. (ed.) Omega-3 fatty acids: metabolism and biological effects Basel, Switzerland Birkhauser Verlag. pp. 27-34

In vivo fatty acid analysis in humans and animals using carbon-13 nuclear magnetic resonance spectroscopy
Cunnane, S.C., Allman, T., Bell, J.D., Barnard, M.L., Coutts, G.A., Williams, S.C.R. and Iles, R.A. 1993. In vivo fatty acid analysis in humans and animals using carbon-13 nuclear magnetic resonance spectroscopy. Basic Life Sciences. 60, pp. 355-358.

NMR: a clinical approach
Bell, J.D. and Sadler, P.J. 1993. NMR: a clinical approach. Chemistry in Britain. 29, pp. 597-600.

Detection of aluminium (III) binding to citrate in human blood plasma by proton nuclear magnetic resonance spectroscopy
Bell, J.D., Kubal, G., Radulovic, S., Sadler, P.J. and Tucker, A. 1993. Detection of aluminium (III) binding to citrate in human blood plasma by proton nuclear magnetic resonance spectroscopy. The Analyst. 118, pp. 241-244.

Phosphorus-31 magnetic resonance spectroscopy of the human liver using chemical shift imaging techniques
Cox, I.J., Menon, D.K., Sargentoni, J., Bryant, D.J., Collins, A.G., Coutts, G.A., Iles, R.A., Bell, J.D., Benjamin, I.S., Gilbey, S., Hodgson, H.J.F. and Morgan, M.Y. 1992. Phosphorus-31 magnetic resonance spectroscopy of the human liver using chemical shift imaging techniques. Journal of Hepatology. 14 (2-3), pp. 265-275.

Effect of l-alanine infusion on 31P nuclear magnetic resonance spectra of normal human liver: towards biochemical pathology in vivo
Dagnelie, P.C., Menon, D.K., Cox, I.J., Bell, J.D., Sargentoni, J., Coutts, G.A., Urenjak, J. and Iles, R.A. 1992. Effect of l-alanine infusion on 31P nuclear magnetic resonance spectra of normal human liver: towards biochemical pathology in vivo. Clinical Science: an international journal of translational science and medicine. 83, pp. 183-190.

In vivo and in vitro31P magnetic resonance spectroscopy of focal hepatic malignancies
Cox, I.J., Bell, J.D., Peden, C.J., Iles, R.A., Foster, C.S., Watanapa, P. and Williamson, R.C.N. 1992. In vivo and in vitro31P magnetic resonance spectroscopy of focal hepatic malignancies. NMR in Biomedicine. 5 (3), pp. 114-120.

MRS characterisation of tissue and body fluids
Bell, J.D. 1992. MRS characterisation of tissue and body fluids. in: Textbook of magnetic resonance spectroscopy in biology and medicine: functional and pathological tissue characterisation Oxford Pergamon.

In vivo detection of metabolic changes in a mouse model of scrapie using nuclear magnetic resonance spectroscopy
Bell, J.D., Cox, I.J., Williams, S.C.R., Belton, P.S., McConnell, I. and Hope, J. 1991. In vivo detection of metabolic changes in a mouse model of scrapie using nuclear magnetic resonance spectroscopy. Journal of General Virology. 72 (10), pp. 2419-2423.

Aluminium speciation: NMR studies of blood plasma, transferrin and citrate complexes
Bell, J.D., Evans, R.W., Kiang, W., Kubal, G., Radulovic, S., Sadler, P.J. and Williams, G. 1991. Aluminium speciation: NMR studies of blood plasma, transferrin and citrate complexes. Journal of Inorganic Biochemistry. 43 (2-3), p. 488.

Metabolites in the developing rat liver: a proton nuclear magnetic resonance spectroscopic study
Rafter, J.E.M., Bates, T.E., Bell, J.D. and Iles, R.A. 1991. Metabolites in the developing rat liver: a proton nuclear magnetic resonance spectroscopic study. Biochimica et Biophysica Acta: general subjects. 1074 (2), pp. 263-269.

Approaches to editing, assignment and interpretation of proton spectra
Gadian, D.G., Bates, T.E., Williams, S.R., Bell, J.D., Austin, S.J. and Connelly, A. 1991. Approaches to editing, assignment and interpretation of proton spectra. NMR in Biomedicine. 4 (2), pp. 85-89.

Proton magnetic resonance spectroscopy in chronic renal failure
Menon, D.K., Cassidy, M.J.D., Baudouin, C., Sandford, R.N., Bell, J.D. and Sargentoni, J. 1991. Proton magnetic resonance spectroscopy in chronic renal failure. The Lancet. 337 (8735), pp. 244-245.

Nuclear magnetic resonance studies of blood plasma and urine from subjects with chronic renal failure: identification of trimethylamine-N-oxide
Bell, J.D., Lee, J.D., Lee, H.A., Sadler, P.J., Wilkie, D.R. and Woodham, R.H. 1991. Nuclear magnetic resonance studies of blood plasma and urine from subjects with chronic renal failure: identification of trimethylamine-N-oxide. Biochimica et Biophysica Acta: general subjects. 1096 (2), pp. 101-107.

Proton MR spectroscopy in herpes simplex encephalitis: assessment of neuronal loss
Menon, D.K., Sargentoni, J., Peden, C.J., Bell, J.D., Cox, I.J., Coutts, G.A., Baudouin, C. and Newman, C.G.H. 1990. Proton MR spectroscopy in herpes simplex encephalitis: assessment of neuronal loss. Journal of Computer Assisted Tomography. 14 (3), pp. 449-452.

31P Magnetic resonance spectroscopy of the human paediatric liver
Iles, R.A., Cox, I.J., Bell, J.D., Dubowitz, L.M.S., Cowan, F.M. and Bryant, D.J. 1990. 31P Magnetic resonance spectroscopy of the human paediatric liver. NMR in Biomedicine. 3 (2), pp. 90-94.

NMR studies of drug metabolism and disposition
Bell, J.D., Gadian, D.G. and Preece, N.E. 1990. NMR studies of drug metabolism and disposition. European Journal of Drug Metabolism and Pharmacokinetics. 15 (2), pp. 127-133.

Proton MR spectroscopy of the brain in infants
Peden, C.J., Cowan, F.M., Bryant, D.J., Sargentoni, J., Cox, I.J., Menon, D.K., Gadian, D.G., Bell, J.D. and Dubowitz, L.M.S. 1990. Proton MR spectroscopy of the brain in infants. Journal of Computer Assisted Tomography. 14 (6), pp. 886-894.

Proton MR spectroscopy of intracranial tumours: in vivo and in vitro studies
Gill, S.S., Thomas, D.G.T., van Bruggen, N., Gadian, D.G., Peden, C.J., Bell, J.D., Cox, I.J., Menon, D.K., Iles, R.A., Bryant, D.J. and Coutts, G.A. 1990. Proton MR spectroscopy of intracranial tumours: in vivo and in vitro studies. Journal of Computer Assisted Tomography. 14 (4), pp. 497-502.

NMR studies of body fluids
Bell, J.D., Brown, J.C.C. and Sadler, P.J. 1989. NMR studies of body fluids. NMR in Biomedicine. 2 (5-6), pp. 246-256.

1H NMR study of cerebral development in the rat
Bates, T.E., Williams, S.R., Gadian, D.G., Bell, J.D., Small, R.K. and Iles, R.A. 1989. 1H NMR study of cerebral development in the rat. NMR in Biomedicine. 2 (5-6), pp. 225-229.

Non-transferrin-bound iron in plasma or serum from patients with idiopathic hemochromatosis. Characterization by high performance liquid chromatography and nuclear magnetic resonance spectroscopy
Grootveld, M., Bell, J.D., Halliwell, B., Aruoma, O.I., Bomford, A. and Sadler, P.J. 1989. Non-transferrin-bound iron in plasma or serum from patients with idiopathic hemochromatosis. Characterization by high performance liquid chromatography and nuclear magnetic resonance spectroscopy. Journal of Biological Chemistry. 264 (8), pp. 4417-4422.

Nuclear magnetic resonance studies of body fluids: an overview
Bell, J.D. 1989. Nuclear magnetic resonance studies of body fluids: an overview. in: de Certaines, J.D. (ed.) Magnetic resonance spectroscopy of biofluids: a new tool in clinical biology London, U.K. World Scientific Publishing.

NMR-invisible lactate in blood plasma
Bell, J.D., Brown, J.C.C., Kubal, G. and Sadler, P.J. 1988. NMR-invisible lactate in blood plasma. FEBS Letters. 235 (1-2), pp. 81-86.

Factors affecting 1h NMR spectra of blood plasma: cancer, diet and freezing
Bell, J.D., Brown, J.C.C., Norman, R.E., Sadler, P.J. and Newell, D.R. 1988. Factors affecting 1h NMR spectra of blood plasma: cancer, diet and freezing. NMR in Biomedicine. 1 (2), pp. 90-94.

Metabolic profiling of body fluids by proton NMR: self-poisoning episodes with paracetamol (acetaminophen)
Bales, J.R., Bell, J.D., Nicholson, J.K., Sadler, P.J., Timbrell, J.A., Hughes, R.D., Bennett, P.N. and Williams, R. 1988. Metabolic profiling of body fluids by proton NMR: self-poisoning episodes with paracetamol (acetaminophen). Magnetic Resonance in Medicine. 6 (3), pp. 300-306.

NMR Spectroscopy of body fluids
Bell, J.D., Brown, J.C.C. and Sadler, P.J. 1988. NMR Spectroscopy of body fluids. Chemistry in Britain. 24, pp. 1021-1024.

Coordination chemistry in biological media: reactions of antitumor Pt(II) and Au(III) complexes with cell culture media
Bell, J.D., Norman, R.E. and Sadler, P.J. 1987. Coordination chemistry in biological media: reactions of antitumor Pt(II) and Au(III) complexes with cell culture media. Journal of Inorganic Biochemistry. 31 (4), pp. 241-246.

1H NMR studies of human blood plasma assignment of resonances for lipoproteins
Bell, J.D., Sadler, P.J., MacLeod, A.F., Turner, P.R. and La Ville, A. 1987. 1H NMR studies of human blood plasma assignment of resonances for lipoproteins. FEBS Letters. 219 (1), pp. 239-243.

Assignment of resonances for ‘acute-phase’ glycoproteins in high resolution proton NMR spectra of human blood plasma
Bell, J.D., Brown, J.C.C., Nicholson, J.K. and Sadler, P.J. 1987. Assignment of resonances for ‘acute-phase’ glycoproteins in high resolution proton NMR spectra of human blood plasma. FEBS Letters. 215 (2), pp. 311-315.

High resolution proton nuclear magnetic resonance studies of human cerebrospinal fluid
Bell, J.D., Brown, J.C.C., Sadler, P.J., MacLeod, A.F., Sönksen, P.H., Hughes, R.D. and Williams, R. 1987. High resolution proton nuclear magnetic resonance studies of human cerebrospinal fluid. Clinical Science: an international journal of translational science and medicine. 72, pp. 563-570.

1H NMR studies of urine during fasting: excretion of ketone bodies and acetylcarnitine
Bales, J.R., Bell, J.D., Nicholson, J.K. and Sadler, P.J. 1986. 1H NMR studies of urine during fasting: excretion of ketone bodies and acetylcarnitine. Magnetic Resonance in Medicine. 3 (6), pp. 849-856.

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