|Title||MRI assessment of the blood-brain barrier in a hamster model of scrapie|
|Authors||Chung, Y.L., Williams, A., Beech, J.S., Williams, S.C.R., Bell, J.D., Cox, I.J. and Hope, J.|
Magnetic resonance (MR) imaging in combination with gadolinium-diethylenetriaminepenta-acetic acid (Gd-DTPA) enhancement was used to investigate the integrity of the blood-brain barrier in a hamster model of scrapie (263K) during the clinical phase of the disease. The post Gd-DTPA images of the infected hamster brain showed marked enhancement, which was not present in control animals. These results suggest that blood-brain barrier function is disrupted in the clinically-affected animal.
|Journal citation||4 (2), pp. 203-207|
|Digital Object Identifier (DOI)||https://doi.org/10.1006/neur.1995.0025|