Hydrophobically modified chitosan nanoliposomes for intestinal drug delivery

Zariwala, M., Bendre, H., Markiv, A., Farnaud, S., Renshaw, D., Taylor, K.M.G. and Somavarapu, S. 2018. Hydrophobically modified chitosan nanoliposomes for intestinal drug delivery. International Journal of Nanomedicine. 2018:13, pp. 5837-5848.

TitleHydrophobically modified chitosan nanoliposomes for intestinal drug delivery
TypeJournal article
AuthorsZariwala, M., Bendre, H., Markiv, A., Farnaud, S., Renshaw, D., Taylor, K.M.G. and Somavarapu, S.
Abstract

Background: Encapsulation of hydrophilic drugs within liposomes can be challenging.
Methods: A novel chitosan derivative, O-palmitoyl chitosan (OPC) was synthesized from chitosan and palmitoyl chloride using methane-sulfonic acid as a solvent. The success of synthesis was confirmed by Fourier transform infra-red (FT-IR) spectroscopy and proton NMR spectroscopy (H-NMR). Liposomes encapsulating ferrous sulphate as a model hydrophilic drug for intestinal delivery were prepared with or without OPC inclusion (Lipo-Fe and OPC-Lipo-Fe).
Results: Entrapment of iron was significantly higher in OPC containing liposomes compared to controls. Quantitative iron absorption from the OPC liposomes was significantly higher (1.5-fold P<0.05) than free ferrous sulphate controls. Qualitative uptake analysis by confocal imaging using coumarin-6 dye loaded liposomes also indicated higher cellular uptake and internalization of the OPC-containing liposomes.
Conclusion: These findings suggest that addition of OPC during liposome preparation creates robust vesicles that have improved mucoadhesive and absorption enhancing properties. The chitosan derivative OPC therefore provides a novel alternative for formulation of delivery vehicles targeting intestinal absorption.

Keywordsgut delivery, intestinal absorption, Caco-2, ferrous sulfate
JournalInternational Journal of Nanomedicine
Journal citation2018:13, pp. 5837-5848
ISSN1176-9114
Year2018
PublisherDove Medical Press Ltd.
Publisher's versionijn-166901-hydrophobically-modified-chitosan-liposomes-for-intestinal-d-092618.pdf
Digital Object Identifier (DOI)doi:10.2147/IJN.S166901
Publication dates
Published27 Sep 2018
LicenseCC BY-NC 3.0

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