Life Sciences

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HeadProf Alistair Mathie
DeputyDr Ian Locke
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Habitual Physical Activity is Associated with Circulating Irisin in Healthy Controls but not in Subjects with Diabetes Mellitus Type 2

Article

Al-Daghri, N.M., Alokail, M.S., Rahman, S., Amer, O.E., Al-Attas, O.S., Alfawaz, H., Tripathi, G., Sabico, S., Chrousos, G.P., McTernan PG and Milan, P.K. 2015. Habitual Physical Activity is Associated with Circulating Irisin in Healthy Controls but not in Subjects with Diabetes Mellitus Type 2. European Journal of Clinical Investigation. 45 (8), pp. 775-781. https://doi.org/10.1111/eci.12468

Recepteur d'Origine nantais (RON) tyrosine kinase splicing variants lacking exons 18 and 19 occur ubiquitously in lung cancer

Article

Krishnaswamy, S., Mohammed, A.K., Amer, O.E., Tripathi, G., Alokail, M.S. and Al-Daghri, N.M. 2015. Recepteur d'Origine nantais (RON) tyrosine kinase splicing variants lacking exons 18 and 19 occur ubiquitously in lung cancer. International Journal of Clinical and Experimental Medicine. 8 (11), pp. 20778-86.

Postprandial effect of a high-fat meal on endotoxemia in arab women with and without insulin-resistance-related diseases

Journal article

Al-Disi, D.A., Al-Daghri, N.M., Khan, N., Alfadda, A.A., Sallam, R.M., Alsaif, M., Sabico, S., Tripathi, G. and McTernan, P.G. 2015. Postprandial effect of a high-fat meal on endotoxemia in arab women with and without insulin-resistance-related diseases. Nutrients. 7 (8), pp. 6375-6389. https://doi.org/10.3390/nu7085290

Vitamin B12 in sufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes

Article

Adaikalakoteswari, A., Finer, S., Voyias, P.D., McCarthy, C.M., Vatish, M., Moore, J., Smart-Halajko, M.C., Bawazeer, N., Al-Daghri, N.M., McTernan, P.G., Kumar, S., Hitman, G.A., Saravanan, P. and Tripathi, G. 2015. Vitamin B12 in sufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes. Clinical Epigenetics. 7 (1), p. 14. https://doi.org/10.1186/s13148-015-0046-8

Platform delivery technologies for nutraceutical applications

Conference paper

Zariwala, M., Somavarapu, S., Evans, R.W., Farnaud, S. and Renshaw, D. 2015. Platform delivery technologies for nutraceutical applications. Vitafoods . Geneva, Switzerland 05 - 07 May 2015

Novel whey protein isolate nanocarriers for oral micronutrient delivery

Conference paper

Farnaud, S., Renshaw, D., Somavarapu, S. and Zariwala, M. 2015. Novel whey protein isolate nanocarriers for oral micronutrient delivery. 9th NIZO Dairy Conference Milk Protein Functionality . Papendal, Netherlands 30 Sep - 02 Oct 2015

Drug Delivery Approaches for Apigenin: A Review

Book chapter

Papay, Z.E., Balogh, E., Zariwala, M., Somavarapu, S. and Antal, I. 2015. Drug Delivery Approaches for Apigenin: A Review. in: Stacks, N.M. (ed.) Apigenin and Naringenin: Natural Sources, Pharmacology and Role in Cancer Prevention New York, USA Nova Science Publishers. pp. 1-20

Biomarkers in Health and Disease: Further Knowledge

Book chapter

Rajendram, R., Rajendram, R., Patel, V.B. and Preedy, V.R. 2015. Biomarkers in Health and Disease: Further Knowledge. in: Preedy, V.R. and Patel, V.B. (ed.) General Methods in Biomarker Research and their Applications Netherlands Springer. pp. 1311-1316

General Methods in Biomarker Research and their Applications, volume 2

Book

Preedy, V.R. and Patel, V.B. (ed.) 2015. General Methods in Biomarker Research and their Applications, volume 2. Springer.

General Methods in Biomarker Research and their Applications, volume 1

Book

Preedy, V.R. and Patel, V.B. (ed.) 2015. General Methods in Biomarker Research and their Applications, volume 1. Springer.

Regional Increase in the Expression of the BCAT Proteins in Alzheimer's Disease Brain: Implications in Glutamate Toxicity

Journal article

Hull, J., Patel, V.B., El Hindy, M., Hezwani, M., Love, S., Kehoe, P.G., Chalmers, C. and Conway, M.E. 2015. Regional Increase in the Expression of the BCAT Proteins in Alzheimer's Disease Brain: Implications in Glutamate Toxicity. Journal of Alzheimer's Disease. 45 (3), pp. 891-905. https://doi.org/10.3233/JAD-142970

New insights into the role of the branched-chain aminotransferase proteins in the human brain

Article

Hull, J., Patel, V.B., Hutson, S.M. and Conway, M.E. 2015. New insights into the role of the branched-chain aminotransferase proteins in the human brain. Journal of Neuroscience Research. 93, pp. 987-998. https://doi.org/10.1002/jnr.23558

Characterisation of hepcidin response to holotransferrin treatment in CHO TRVb-1 cells

Article

Mehta, K., Greenwell, P., Renshaw, D., Busbridge, Mark, Garcia, M, Farnaud, S. and Patel, V. B. 2015. Characterisation of hepcidin response to holotransferrin treatment in CHO TRVb-1 cells. Blood Cells, Molecules, and Diseases. 55 (2), pp. 110-118. https://doi.org/10.1016/j.bcmd.2015.05.002

Resilience: what is it, why do we need it, and can it help us?

Article

Lown, M., Lewith,, G., Simon, C. and Peters, D. 2015. Resilience: what is it, why do we need it, and can it help us? British Journal of General Practice. 65 (639), p. e708–e710. https://doi.org/10.3399/bjgp15X687133

Hanseniaspora jakobsenii sp. nov., a yeast isolated from Bandji, a traditional palm wine of Borassus akeassii

Article

Ouoba, L.I.I., Nielsen, D.S., Anyogu, A., Kando, C., Diawara, B., Jespersen, L. and Sutherland, J.P. 2015. Hanseniaspora jakobsenii sp. nov., a yeast isolated from Bandji, a traditional palm wine of Borassus akeassii. International Journal of Systematic and Evolutionary Microbiology. 65, pp. 3576-3579. https://doi.org/10.1099/ijsem.0.000461

Lysinibacillus louembei sp. nov., a spore-forming bacterium isolated from Ntoba Mbodi, alkaline fermented leaves of cassava from the Republic of the Congo

Journal article

Ouoba, L.I.I., Mbozo, A.B.V., Thorsen, L., Anyogu, A., Nielsen, D.S., Kobawila, S.C. and Sutherland, J.P. 2015. Lysinibacillus louembei sp. nov., a spore-forming bacterium isolated from Ntoba Mbodi, alkaline fermented leaves of cassava from the Republic of the Congo. International Journal of Systematic and Evolutionary Microbiology. 65, pp. 4256-4262. https://doi.org/10.1099/ijsem.0.000570

Comparison of different hand drying methods: the potential for microbe dispersal

Article

Best, E.L. and Redway, K. 2015. Comparison of different hand drying methods: the potential for microbe dispersal. Journal of Hospital Infection. 89 (3), pp. 215-217. https://doi.org/10.1016/j.jhin.2014.11.007

Forward-in-Time, Spatially Explicit Modeling Software to Simulate Genetic Lineages Under Selection

Article

Currat, M., Gerbault, P., Di, D., Nunes, J.M. and Sanchez-Mazas, A. 2015. Forward-in-Time, Spatially Explicit Modeling Software to Simulate Genetic Lineages Under Selection. Evolutionary Bioinformatics. 11 (Supp-2), pp. 27-39. https://doi.org/10.4137/EBO.S33488

Greenlandic Inuit show genetic signatures of diet and climate adaptation

Journal article

Fumagalli, M., Moltke, I., Grarup, N., Racimo, F., Bjerregaard, P., Jørgensen, M.E., Korneliussen, T.S., Gerbault, P., Skotte, L., Linneberg, A., Christensen, C., Brandslund, I., Jørgensen, T., Huerta-Sánchez, E., Schmidt, E.B., Pedersen, O., Hansen, T., Albrechtsen, A. and Nielsen, R. 2015. Greenlandic Inuit show genetic signatures of diet and climate adaptation. Science. 349 (6254), pp. 1343-1347. https://doi.org/10.1126/science.aab2319

Widespread exploitation of the honeybee by early Neolithic farmers

Journal article

Roffet-Salque, M., Regert, M., Evershed, R.P., Outram, A.K., Cramp, L.J., Decavallas, O., Dunne, J., Gerbault, P., Mileto, S., Mirabaud, S., Paakkonen, M., Smyth, J., Soberl, L., Whelton, H.L., Alday-Ruiz, A., Asplund, H., Bartkowiak, M., Bayer-Niemeier, E., Belhouchet, L., Bernardini, F., Budja, M., Cooney, G., Cubas, M., Danaher, E.M., Diniz, M., Domboroczki, L., Fabbri, C., Gonzalez-Urquijo, J.E., Guilaine, J., Hachi, S., Hartwell, B.N., Hofmann, D., Hohle, I., Ibanez, J.J., Karul, N., Kherbouche, F., Kiely, J., Kotsakis, K., Lueth, F., Mallory, J.P., Manen, C., Marciniak, A., Maurice-Chabard, B., Mc Gonigle, M.A., Mulazzani, S., Ozdogan, M., Peric, O.S., Peric, S.R., Petrasch, J., Petrequin, A.M., Petrequin, P., Poensgen, U., Pollard, C.J., Poplin, F., Radi, G., Stadler, P., Stauble, H., Tasic, N., Urem-Kotsou, D., Vukovic, J.B., Walsh, F., Whittle, A., Wolfram, S., Zapata-Pena, L. and Zoughlami, J. 2015. Widespread exploitation of the honeybee by early Neolithic farmers. Nature. 527 (7577), pp. 226-230. https://doi.org/10.1038/nature15757

Human evolutionary genetics

Book chapter

Gerbault, P. and Thomas, M.G. 2015. Human evolutionary genetics. in: International encyclopedia of the social & behavioral sciences (second edition) Elsevier. pp. 289-296

Barriers to working with people affected by cancer: Preliminary qualitative data from a mixed methods exploration of practitioner perspectives in nutritional therapy

Article

Granger, C.A., Pilkington, K., Draper, A. and Polley, M.J. 2015. Barriers to working with people affected by cancer: Preliminary qualitative data from a mixed methods exploration of practitioner perspectives in nutritional therapy. European Journal of Integrative Medicine. 7 (6), p. 681. https://doi.org/10.1016/j.eujim.2015.07.009

The role of acute ambient hypoxia in the regulation of myostatin

PhD thesis

Elliott, B. 2015. The role of acute ambient hypoxia in the regulation of myostatin. PhD thesis University of Westminster Biomedical Sciences https://doi.org/10.34737/9ww8v

Curriculum and beyond: Mathematics support for first year life science students

Conference paper

Bailey, I., Ferrier, C. and Smith, C.L. 2015. Curriculum and beyond: Mathematics support for first year life science students. CETL-MSOR Conference 2015. University of Greenwich 08 Sep 2015 The Sigma Network.

The effect of a selective CXCR2 antagonist (AZD5069) on human blood neutrophil count and innate immune functions.

Journal article

Jurcevic, S., Humfrey, C., Uddin, M., Warrington, S., Larsson, B. and Keen, C. 2015. The effect of a selective CXCR2 antagonist (AZD5069) on human blood neutrophil count and innate immune functions. Br J Clin Pharmacol. . 80 (6), pp. 1324-36. https://doi.org/10.1111/bcp.12724

The effect of melanocortin peptides on Interleukin 1-beta induced chondrocyte cell death and inflammation

Conference poster

Can, V.C., Locke, I.C. and Getting, S.J. 2015. The effect of melanocortin peptides on Interleukin 1-beta induced chondrocyte cell death and inflammation. Physiology 2015 . Cardiff, UK. 08 Jul 2015

Urocortin – From Parkinson’s disease to the skeleton

Journal article

Lawrence, K.M., Jackson, T.R, Jamieson, D., Stevens, A., Owens, G., Sayan, B.S, Locke, I.C. and Townsend, P.A. 2015. Urocortin – From Parkinson’s disease to the skeleton. International Journal of Biochemistry & Cell Biology. 30, pp. 130-138. https://doi.org/10.1016/j.biocel.2014.12.005

Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytes.

Journal article

di Gesso, J.L., Kerr, J.S., Zhang, Q., Raheem, S., Yalamanchili, S.K., O’Hagan, D., Kay, C.D. and O'Connell, M.A. 2015. Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytes. Molecular Nutrition & Food Research. 59 (6), pp. 1143-1154. https://doi.org/10.1002/mnfr.201400799

Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells

Journal article

Amin, H.P., Czank, C., Raheem, S., Zhang, Q., Botting, N.P., Cassidy, A. and Kay, C.D. 2015. Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells. Molecular Nutrition & Food Research. 59 (6), pp. 1095-1106. https://doi.org/10.1002/mnfr.201400803

Prostate cancer cells stimulated by calcium-mediated activation of protein kinase C undergo a refractory period before re-releasing calcium-bearing microvesicles

Article

Lange, S., Stratton, D., Moore, C., Inal, J., Zheng, L. and Li, Z. 2015. Prostate cancer cells stimulated by calcium-mediated activation of protein kinase C undergo a refractory period before re-releasing calcium-bearing microvesicles. Biochemical and Biophysical Research Communications. 460 (3), pp. 511-517. https://doi.org/10.1016/j.bbrc.2015.03.061

Microvesicles released constitutively from prostate cancer cells differ biochemically and functionally to stimulated microvesicles released through sublytic C5b-9

Article

Lange, S., Stratton, D., Moore, C., Antwi-Baffour, S. and Inal, J. 2015. Microvesicles released constitutively from prostate cancer cells differ biochemically and functionally to stimulated microvesicles released through sublytic C5b-9. Biochemical and Biophysical Research Communications. 460 (3), p. 589–595. https://doi.org/10.1016/j.bbrc.2015.03.074

Data-driven Hippocampus CA1 Modeling in the Human Brain Project

Conference poster

Romani, A., Antille, N., Mercer, A., Dynes, J.A., Falk, J., Gevaert, M., Gonzalo, J.K., Kali, S., Kanari, L., Migliore, M., Lange, S., Muller, E.B., Ramaswamy, S., Reimann, M., Riquelme, R.J.L., Rössert, C.A., Shi, Y., Telefont, M., Van Geit, W.A.H., Markram, H., Thomson, A. and W.A.H. Van Geit 2015. Data-driven Hippocampus CA1 Modeling in the Human Brain Project. Neuroscience 2015. Chicago 17 Oct 2015 Society for Neuroscience.

Wearable technology in academia: the use of Google Glass in the life sciences

Article

Elliott, B. and Sukan, A. 2015. Wearable technology in academia: the use of Google Glass in the life sciences. Compass: Journal of Learning & Teaching . 6 (10).

Digestive system

Book chapter

Warford, A. and Madgwick, A. 2015. Digestive system. in: Orchard, G. and Nation, B. (ed.) Cell Structure and Function Oxford UK Oxford University Press. pp. 220-245

The effect of melanocortin peptides on Interleukin 1-beta induced chondrocyte cell death and inflammation

Conference poster

Can, V.C., Locke, I.C. and Getting, S.J. 2015. The effect of melanocortin peptides on Interleukin 1-beta induced chondrocyte cell death and inflammation. Physiology 2015. Cardiff Jun 2015

A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy

Journal article

Kholia, S., Jorfi, S., Thompson, P.R., Causey, C.P., Nicholas, A.P., Inal, J. and Lange, S. 2015. A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy. Journal of Extracellular Vesicles. 4 (1) 26192. https://doi.org/10.3402/jev.v4.26192

Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo

Journal article

Jorfi, S., Ansa-Addo, E.A., Kholia, S., Stratton, D., Valley, S., Lange, S. and Inal, J. 2015. Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo. Scientific Reports. 5 (13006) 13006. https://doi.org/10.1038/srep13006

Correlation between the expression of CD32 and CD180 receptors on CLL cells and MEC1 cell line

Article

Tsertsvadze, T., Mitskevich, N., Ghirdaladze, D. and Porakishvili, N. 2015. Correlation between the expression of CD32 and CD180 receptors on CLL cells and MEC1 cell line. Georgian Medical News. 3 (240), pp. 56-59.

Rewiring of sIgM-mediated intracellular signaling through theCD180 Toll-like receptor

Journal article

Porakishvili, N., Vispute, K., Rajakaruna, N., Kulikova, N., Tsertsvadze, T., Nathwani, A., Damle, R.N., Clark, E.A., Rai, K.R., Chiorazzi, N. and Lydyard, P.M. 2015. Rewiring of sIgM-mediated intracellular signaling through theCD180 Toll-like receptor. Molecular Medicine. 21, pp. 46-57. https://doi.org/10.2119/molmed.2014.00265

What works for Nutrition? Stories of success from Vietnam, Uganda and Kenya

Technical report

RESULTS, U.K., Concern Worldwide, University of Westminster and Keith, R. 2015. What works for Nutrition? Stories of success from Vietnam, Uganda and Kenya. London, UK Results UK.


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