Life Sciences

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Integrating molecular modelling methods to advance influenza A virus drug discovery

Journal article

Patel, H. and Kukol, A. 2021. Integrating molecular modelling methods to advance influenza A virus drug discovery. Drug Discovery Today. 26 (2), pp. 503-510. https://doi.org/10.1016/j.drudis.2020.11.014

The chimera of choice in UK food policy 1976-2018

Journal article

Burges Watson, D.L., Draper, A. and Willis, W.J. 2021. The chimera of choice in UK food policy 1976-2018. British Food Journal. 123 (4), pp. 1596-1609. https://doi.org/10.1108/BFJ-10-2020-0982

Peptidylarginine deiminases and extracellular vesicles: prospective drug targets and biomarkers in central nervous system diseases and repair.

Journal article

Lange, Sigrun 2021. Peptidylarginine deiminases and extracellular vesicles: prospective drug targets and biomarkers in central nervous system diseases and repair. Neural Regeneration Research. 16 (5), pp. 934-938. https://doi.org/10.4103/1673-5374.297058

Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study

Journal article

Bizzotto, R., Jennison, C., Jones, A., Kurbasic, A., Kennedy, G., Bell, J.D., Thomas, E.L., Frost, G., Eriksen, R., Koivula, R., Brage, S., Kaye, J., Hattersley, A., Heggie, A., McEvoy, D., Hart, L.M., Beulens, J.W., Elders, P., Musholt, P.B., Ridderstråle, M., Hansen, T., Allin, K., Hansen, T., Vestergaard, H., Lundgaard, A.T., Thomsen, H.S., Masi, F., Tsirigos, K.D., Brunak, S., Viñuela, A., Mahajan, A., McDonald, T.J., Kokkola, T., Forgie, I., Giordano, G.N., Pavo, I., Ruetten, H., Dermitzakis, E., McCarthy, M., Pedersen, O., Schwenk, J., Adamski, J., Franks, P., Walker, M., Pearson, E. and Mari, A. 2021. Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study. Diabetes Care. 44 (2), pp. 511-518. https://doi.org/10.2337/dc20-1567

The effect of astaxanthin supplementation on performance and fat oxidation during a 40 km cycling time trial

Journal article

Brown, D.R., Warner, A.R., Deb, S., Gough, L.A., Sparks, S.A. and McNaughton, L.R. 2021. The effect of astaxanthin supplementation on performance and fat oxidation during a 40 km cycling time trial. Journal of Science and Medicine in Sport. 24 (1), pp. 92-97. https://doi.org/10.1016/j.jsams.2020.06.017

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain

Journal article

Alić, I., Goh, P.A., Murray, A., Portelius, E., Gkanatsiou, E., Gough, G., Mok, K.Y., Koschut, D., Brunmeir, R., Yeap, Y.J., O'Brien, N.L., Groet, J., Shao, X,, Havlicek, S., Dunn, N.R., Kvartsberg, H., Brinkmalm, G., Hithersay, R,, Startin, C., Hamburg, S., Phillips, M., Pervushin, K., Turmaine, M., Wallon, D., Rovelet-Lecrux, A., Soininen, H., Volpi, E., Martin, J.E., Foo, J.N., Becker, D.L., Rostagno, A., Ghiso, J., Krsnik, Ž., Šimić, G., Kostović, I., Mitrečić, D., LonDownS Consortium, Francis, P.T., Blennow, K., Strydom, A., Hardy, J., Zetterberg, H. and Nižetić, D. 2021. Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain. Molecular Psychiatry. 26, p. 5766–5788. https://doi.org/10.1038/s41380-020-0806-5

Nutritional Management in Polycystic Ovary Syndrome: Challenges and opportunities

Journal article

Hmedeh, C., Ghazeeri, G. and Tewfik, I. 2021. Nutritional Management in Polycystic Ovary Syndrome: Challenges and opportunities. International Journal of Food Safety, Nutrition and Public Health. 6 (2), pp. 120-130. https://doi.org/10.1504/IJFSNPH.2021.113389

Dr Manal Mohammed for The Independent on handwashing and hand-sanitisers

Other

Mohammed, M. Forthcoming. Dr Manal Mohammed for The Independent on handwashing and hand-sanitisers. The Conversation.

Patterns in nature - the true art of microscopy

Exhibition

Lange, S. 2020. Patterns in nature - the true art of microscopy. University of Westminster

Breast Cancer Detection and Treatment Monitoring Using a Noninvasive Prenatal Testing Platform: Utility in Pregnant and Nonpregnant Populations.

Journal article

Lenaerts, L., Che, H., Brison, N., Neofytou, M., Jatsenko, T., Lefrère, H., Maggen, C., Villela, D., Verheecke, M., Dehaspe, L., Croitor, A., Hatse, S., Wildiers, H., Neven, P. and Amant, F. 2020. Breast Cancer Detection and Treatment Monitoring Using a Noninvasive Prenatal Testing Platform: Utility in Pregnant and Nonpregnant Populations. Clinical Chemistry. 66 (11), pp. 1414-1423. https://doi.org/10.1093/clinchem/hvaa196

Predicting fetoplacental mosaicism during cfDNA-based NIPT.

Journal article

Neofytou, M. 2020. Predicting fetoplacental mosaicism during cfDNA-based NIPT. Current Opinion in Obstetrics and Gynecology. 32 (2), pp. 152-158. https://doi.org/10.1097/gco.0000000000000610

Differential anti-proliferative and anti-migratory activities of ursolic acid, 3-O-acetylursolic acid and their combination treatments with quercetin on melanoma cells

Journal article

Alqathama, A., Shao, L., Bader, A., Khondkar, P., Gibbons, S. and Prieto, J.M. 2020. Differential anti-proliferative and anti-migratory activities of ursolic acid, 3-O-acetylursolic acid and their combination treatments with quercetin on melanoma cells. biomolecules. 10 (6) 894. https://doi.org/10.3390/biom10060894

How to make hand sanitiser gel

Journal article

Choon Fu Goh and Abeer H.A. Mohamed Ahmed 2020. How to make hand sanitiser gel. Community Eye Health. 33 (109) 26.

How to make hand sanitiser/hand rub

Journal article

Abeer H.A. Mohamed Ahmed and Choon Fu Goh 2020. How to make hand sanitiser/hand rub. Community Eye Health. 33 (109), pp. 24-25.

Noninvasive prenatal diagnosis by genome-wide haplotyping of cell-free plasma DNA

Journal article

Huiwen Che, Darine Villela, Eftychia Dimitriadou, Cindy Melotte, Nathalie Brison, Maria Neofytou, Kris Van Den Bogaert, Olga Tsuiko, Koen Devriendt, Eric Legius, Masoud Zamani Esteki, Thierry Voet and Joris Robert Vermeesch 2020. Noninvasive prenatal diagnosis by genome-wide haplotyping of cell-free plasma DNA. Genetics in Medicine. 22 (5), pp. P962-973. https://doi.org/10.1038/s41436-019-0748-y

N-Acetylcysteine Nanocarriers Protect against Oxidative Stress in a Cellular Model of Parkinson’s Disease

Journal article

Mursaleen, L., Noble, B., Chan, S.H.Y., Somavarapu, S. and Zariwala, M. 2020. N-Acetylcysteine Nanocarriers Protect against Oxidative Stress in a Cellular Model of Parkinson’s Disease. Antioxidants. 9 (7) 600. https://doi.org/10.3390/antiox9070600

Cover Image, Volume 30, Issue 11

Article

András Ecker, Armando Romani, Sára Sáray, Szabolcs Káli, Michele Migliore, Joanne Falck, Sigrun Lange, Audrey Mercer, Alex M. Thomson, Eilif Muller, Michael W. Reimann and Srikanth Ramaswamy 2020. Cover Image, Volume 30, Issue 11. Hippocampus. 30 (11), p. C1. https://doi.org/10.1002/hipo.23273

Supplementation with a prebiotic (polydextrose) in obese mouse pregnancy improves maternal glucose homeostasis and protects against offspring obesity

Journal article

Maragkoudaki, X., Naylor, M., Papacleovoulou, G., Stolarczyk, E., Rees, D., Pombo, J.M., Abu-Hayyeh, S., Czajka, A., Howard, J.K., Malik, A.N., Williamson, C., Poston, L. and Taylor, P.D. 2020. Supplementation with a prebiotic (polydextrose) in obese mouse pregnancy improves maternal glucose homeostasis and protects against offspring obesity. International Journal of Obesity. 44, pp. 2382-2393. https://doi.org/10.1038/s41366-020-00682-5

Pharmacists detecting atrial fibrillation in general practice: a qualitative focus group study.

Journal article

Savickas, V., Veale, E.L., Bhamra, S.K., Stewart, A.J., Mathie, A. and Corlett, S. 2020. Pharmacists detecting atrial fibrillation in general practice: a qualitative focus group study. BJGP Open. 4 (3) bjgpopen20X101042. https://doi.org/10.3399/bjgpopen20x101042

TASK-3 Two-Pore Potassium Channels drive neuronal excitability of the circadian clock and entrainment to challenging light environments

Other

Aiste Steponenaite, Tatjana Lalic, Lynsey Atkinson, Liting Wei, Alistair Mathie, M. Zameel Cader and Gurprit S. Lall 2020. TASK-3 Two-Pore Potassium Channels drive neuronal excitability of the circadian clock and entrainment to challenging light environments. biorxiv.org. https://doi.org/10.1101/2020.07.27.222885

TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses

Journal article

Tatjana Lalic, Aiste Steponenaite, Liting Wei, Sridhar R. Vasudevan, Alistair Mathie, Stuart N. Peirson, Gurprit S. Lall and M. Zameel Cader 2020. TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses. Nature Communications . 11 4614. https://doi.org/10.1038/s41467-020-17978-9

Opportunistic screening for atrial fibrillation by clinical pharmacists in UK general practice during the influenza vaccination season: A cross-sectional feasibility study.

Journal article

Savickas, Vilius, Stewart, Adrian J., Rees-Roberts, Melanie, Short, Vanessa, Bhamra, Sukvinder K., Corlett, Sarah A., Mathie, A. and Veale, Emma L. 2020. Opportunistic screening for atrial fibrillation by clinical pharmacists in UK general practice during the influenza vaccination season: A cross-sectional feasibility study. PLoS Medicine. 17 (7) e1003197. https://doi.org/10.1371/journal.pmed.1003197

Multiscale, multidomain analysis of microvascular flow dynamics

Journal article

Chipperfield, A.J., Thanaj, M. and Clough, G.F. 2020. Multiscale, multidomain analysis of microvascular flow dynamics. Experimental Physiology. 105 (9), pp. 1452-1458. https://doi.org/10.1113/ep087874

Natto and Vitamin K2: a promising nutraceutical aid for bone maintenance

Journal article

Kitching, V. and Tewfik, I. 2020. Natto and Vitamin K2: a promising nutraceutical aid for bone maintenance. International Journal of Food, Nutrition and Public Health.

Evaluating the effectiveness of a tailored health educational health toolkit to modulate Type 2 Diabetes Mellitus and restrain its complications

Journal article

Mbiatem, M. E. and Tewfik, I. 2020. Evaluating the effectiveness of a tailored health educational health toolkit to modulate Type 2 Diabetes Mellitus and restrain its complications. International Journal of Food, Nutrition and Public Health. 12 (1/2), pp. 41- 62.

Investigating chemical changes during Snake fruit and Black tea Kombucha fermentation and the associated immunomodulatory activity in Salmonella typhi-infected mice

Journal article

Zubaidah, E., Valencia, V., Rifa'i, M., Srianta, I. and Tewfik, I. 2020. Investigating chemical changes during Snake fruit and Black tea Kombucha fermentation and the associated immunomodulatory activity in Salmonella typhi-infected mice. Potravinarstvo Slovak Journal of Food Sciences. 14, pp. 995-1000. https://doi.org/10.5219/1416

Novel antibiotic-loaded particles conferring eradication of deep tissue bacterial reservoirs for the treatment of chronic urinary tract infection

Journal article

Wai K. Lau, Dhanuson Dharmasena, Harry Horsley, Nazila Jafari, James Malone-Lee, Eleanor Stride, Mohan Edirisinghe and Jennifer L. Rohn 2020. Novel antibiotic-loaded particles conferring eradication of deep tissue bacterial reservoirs for the treatment of chronic urinary tract infection. Journal of Controlled Release. 328, pp. 490-502. https://doi.org/10.1016/j.jconrel.2020.08.048

Preprint: Image Processing and Quality Control for Abdominal Magnetic Resonance Imaging in the UK Biobank

Other

Basty, N., Liu, Yi, Cule, M., Thomas, E. Louise, Bell, J.D. and Whitcher, B. 2020. Preprint: Image Processing and Quality Control for Abdominal Magnetic Resonance Imaging in the UK Biobank. arXiv.

Preprint: Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study

Other

Atabaki-Pasdar, N., Ohlsson, M., Vinuela, A., Frau, F., Pomares-Millan, H., Haid, M., Jones, A. G., Thomas, E. L., Koivula, R. W., Kurbasic, A., Mutie, P. M., Fitipaldi, H., Fernandez, J., Dawed, A. Y., Giordano, G. N., Forgie, I. M., McDonald, T. J., Rutters, F., Cederberg, H., Chabanova, E., Dale, M., Masi, F. D., Thomas, C. E., Allin, K. H., Hansen, T. H., Heggie, A., Hong, M.-G., Elders, P. J., Kennedy, G., Kokkola, T., Pedersen, H. K., Mahajan, A., McEvoy, D., Pattou, F., Raverdy, V., Haussler, R. S., Sharma, S., Thomsen, H. S., Vangipurapu, J., Vestergaard, H., 't Hart, L. M. and Adamski, J. 2020. Preprint: Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study. medRxiv. https://doi.org/10.1101/2020.02.10.20021147

Pertussis in Lao PDR: Seroprevalence and disease

Journal article

Kleine, Daria, Billamay, Somxay, Chanthavilay, Phetsavanh, Mongkhoune, Sodaly, Keokhamphoui, Chirapha, Souksakhone, Chanthala, Nouanthong, Phonethipsavanh, Khamphaphongphane, Bouaphan, Muller, Claude P. and Black, Antony P. 2020. Pertussis in Lao PDR: Seroprevalence and disease. International Journal of Infectious Diseases. 95, pp. p282-287. https://doi.org/10.1016/j.ijid.2020.03.074

Hepatitis A virus in Lao People’s Democratic Republic: Seroprevalence and risk factors

Journal article

Khounvisith, Vilaysone, Xaiyaphet, Xaipasong, Chanthavilay, Phetsavanh, Nouanthong, Phonethipsavanh, Vongphachanh, Bounta, Reinharz, Daniel, Muller, Claude P. and Black, Antony P. 2020. Hepatitis A virus in Lao People’s Democratic Republic: Seroprevalence and risk factors. The American Journal of Tropical Medicine and Hygiene. 103 (1), pp. 164-168. https://doi.org/10.4269/ajtmh.19-0451

Lasting benefit of infant hepatitis B vaccination in adolescents in the Lao People’s Democratic Republic

Journal article

Hefele, Lisa, Vannachone, Souphaphone, Khounvisith, Vilaysone, Nouanthong, Phonethipsavanh, Sayasone, Somphou, Kounnavong, Sengchang, Chanthavilay, Phetsavanh, Muller, Claude P. and Black, Antony P. 2020. Lasting benefit of infant hepatitis B vaccination in adolescents in the Lao People’s Democratic Republic. International Journal of Infectious Diseases. 93, pp. 217-223. https://doi.org/10.1016/j.ijid.2020.01.055

Association between maternal serum homocysteine concentrations in early pregnancy and adverse pregnancy outcomes

Journal article

Nwogu, C., Okunade, K., Adenekan, M., Sekumade, A., John-Olabode, S. and Oluwole, A. 2020. Association between maternal serum homocysteine concentrations in early pregnancy and adverse pregnancy outcomes. Annals of African Medicine. 19 (2), pp. 113-118. https://doi.org/10.4103/aam.aam_41_19

Prevalence of Rhesus C and D Alloantibodies among Rhesus-Negative Women of Child Bearing Age at a Tertiary Hospital in South-West Nigeria

Journal article

Otomewo, L., John-Olabode, S., Okunade, K., Olorunfemi, G. and Ajie, I. 2020. Prevalence of Rhesus C and D Alloantibodies among Rhesus-Negative Women of Child Bearing Age at a Tertiary Hospital in South-West Nigeria. Nigerian Journal of Clinical Practice. 23 (12), pp. 1759-1766. https://doi.org/10.4103/njcp.njcp_114_20

Prognostic impact of pretreatment thrombocytosis in epithelial ovarian cancer

Journal article

Okunade, K., Dawodu, O., Adenekan, M., Nwogu, C.M., Awofeso, O., Ugwu, A.O., Salako, O., John-Olabode, S., Olowoselu, O. and Anorlu, R. 2020. Prognostic impact of pretreatment thrombocytosis in epithelial ovarian cancer. Nigerian Journal of Clinical Practice. 23 (8), pp. 1141-1147. https://doi.org/10.4103/njcp.njcp_134_19

Seroprevalence of anti-tetanus antibodies in mothers and cord blood and associated factors in health-care settings in Lao People’s Democratic Republic

Journal article

Ounnavong, Phoumsavath, Chanthavilay, Phetsavanh, Khampanisong, Phonepaseuth, Reinharz, Daniel, Muller, Claude P and Black, A. 2020. Seroprevalence of anti-tetanus antibodies in mothers and cord blood and associated factors in health-care settings in Lao People’s Democratic Republic. Vaccine. 38 (5), pp. 1234-1240. https://doi.org/10.1016/j.vaccine.2019.11.007

Timeliness of immunisation with the pentavalent vaccine at different levels of the health care system in the Lao People’s Democratic Republic: A cross-sectional study

Journal article

Hefele, Lisa, Syphan, Sengdavanh, Xayavong, Dalouny, Homsana, Anousin, Kleine, Daria, Chanthavilay, Phetsavanh, Nouanthong, Phonethipsavanh, Xaydalasouk, Kinnaly, Phathammavong, Outavong, Billamay, Somxay, Xeuatvongsa, Anonh, Reinharz, Daniel, Black, Antony and Muller, Claude P. 2020. Timeliness of immunisation with the pentavalent vaccine at different levels of the health care system in the Lao People’s Democratic Republic: A cross-sectional study. PLoS ONE. https://doi.org/10.1371/journal.pone.0242502

Targeting the MAPK7/MMP9 axis for metastasis in primary bone cancer

Journal article

Green, D., Eyre, H., Singh, A., Taylor, T, J., Chu, J., Jeys, L., Sumathi, V., Coonar, A., Rassl, D., Babur, M., Forster, D., Alzabin, S., Ponthan, F., McMahon, A., Bigger, B., Reekie, T., Kassiou, M., Williams, K., Dalmay, T., Fraser, D, W. and Finegan, G, F. 2020. Targeting the MAPK7/MMP9 axis for metastasis in primary bone cancer. Oncogene. https://doi.org/10.1038/s41388-020-1379-0

Immune monitoring of a child with autoimmune hepatitis and type 1 diabetes during COVID-19 infection

Journal article

Yuksel, M., Akturk, H. and Arikan, C. 2020. Immune monitoring of a child with autoimmune hepatitis and type 1 diabetes during COVID-19 infection. European Journal of Gastroenterology and Hepatology. 32 (9), pp. 1251-1255. https://doi.org/10.1097/meg.0000000000001804

Measuring single cell divisions in human tissues from multi-region sequencing data

Journal article

Benjamin Werner, Jack Case, Marc Williams, Ketevan Chkhaidze, Daniel Temko, Javier Fernández-Mateos, George David Cresswell, Daniel Nichol, William Cross, Inmaculada Spiteri, Weini Huang, Tomlinson, I., Chris Barnes, Trevor Graham and Andrea Sottoriva 2020. Measuring single cell divisions in human tissues from multi-region sequencing data. Nature Communications . 11 1035. https://doi.org/10.1038/s41467-020-14844-6


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