Life Sciences

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HeadProf Alistair Mathie
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Variational Bayesian inference for a nonlinear forward model

Journal article

Chappell, M.A., Groves, A.R., Whitcher, B. and Woolrich, M.W. 2009. Variational Bayesian inference for a nonlinear forward model. IEEE Transactions on Signal Processing. 57 (1), pp. 223-236. https://doi.org/10.1109/tsp.2008.2005752

Agonist occupancy is essential for forward trafficking of AMPA receptors.

Journal article

Coleman, S.K., Möykkynen, T., Jouppila, A., Koskelainen, S., Rivera, C., Korpi, E.R. and Keinänen, K. 2009. Agonist occupancy is essential for forward trafficking of AMPA receptors. Journal of Neuroscience. 29 (2), pp. 303-312. https://doi.org/10.1523/jneurosci.3953-08.2009

Dynamic visualization of membrane-inserted fraction of pHluorin-tagged channels using repetitive acidification technique.

Journal article

Khiroug, S.S., Pryazhnikov, E., Coleman, S.K., Jeromin, A., Keinänen, K. and Khiroug, L. 2009. Dynamic visualization of membrane-inserted fraction of pHluorin-tagged channels using repetitive acidification technique. BMC Neuroscience. 10 141. https://doi.org/10.1186/1471-2202-10-141

Ethanol increases desensitization of recombinant GluR-D AMPA receptor and TARP combinations

Edited issue

Tommi P. Möykkynen, Coleman, S.K., Kari Keinänen, David M. Lovinger and Esa R. Korpi 2009. Ethanol increases desensitization of recombinant GluR-D AMPA receptor and TARP combinations. Alcohol. 43 (4), pp. 277-284. https://doi.org/10.1016/j.alcohol.2009.04.005

DECIPHER: Shedding Light on Chromosomal Imbalance and Phenotype Interpretation

Conference paper

Corpas, M., Richards, S., Bevan, P., van Vooren, S., Pettett, R., Firth, H. and Carter, N. 2009. DECIPHER: Shedding Light on Chromosomal Imbalance and Phenotype Interpretation. 7th European Cytogenetics Conference. Stockholm, Sweden 04 - 07 Jul 2009

DECIPHER: Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl Resources.

Journal article

Firth, H.V., Richards, S.M., Bevan, A.P., Clayton, S., Corpas, M., Rajan, D., Van Vooren, S., Moreau, Y., Pettett, R.M. and Carter, N.P. 2009. DECIPHER: Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl Resources. The American Journal of Human Genetics. 84 (4), pp. P524-533. https://doi.org/10.1016/j.ajhg.2009.03.010

Mapping of partially overlapping de novo deletions across an autism susceptibility region (AUTS5) in two unrelated individuals affected by developmental delays with communication impairment.

Journal article

Newbury, D.F., Warburton, P.C., Wilson, N., Bacchelli, E., Carone, S., International Molecular Genetic Study of Autism Consortium, Lamb, J.A., Maestrini, E., Monaco, A.P. and Volpi, E. 2009. Mapping of partially overlapping de novo deletions across an autism susceptibility region (AUTS5) in two unrelated individuals affected by developmental delays with communication impairment. American Journal of Medical Genetics Part A. 149A (4), pp. 588-597. https://doi.org/10.1002/ajmg.a.32704

HAC stability in murine cells is influenced by nuclear localization and chromatin organization.

Journal article

Moralli, D., Chan, D.Y., Jefferson, A., Volpi, E.V. and Monaco, Z.L. 2009. HAC stability in murine cells is influenced by nuclear localization and chromatin organization. BMC Cell Biology. 10 18. https://doi.org/10.1186/1471-2121-10-18

Copy number variation and association analysis of SHANK3 as a candidate gene for autism in the IMGSAC collection.

Journal article

Sykes, N.H., Toma, C., Wilson, N., Volpi, E., Sousa, I., Pagnamenta, A.T., Tancredi, R., Battaglia, A., Maestrini, E., Bailey, A.J., Monaco, A.P. and International Molecular Genetic Study of Autism Consortium (IMGSAC) 2009. Copy number variation and association analysis of SHANK3 as a candidate gene for autism in the IMGSAC collection. European Journal of Human Genetics. 17, pp. 1347-1353. https://doi.org/10.1038/ejhg.2009.47

Severe insulin resistance and intrauterine growth deficiency associated with haploin sufficiency for INSR and CHN2: new insights into synergistic pathways involved in growth and metabolism

Journal article

Suliman, S.G., Stanik, J., McCulloch, L.J., Wilson, N., Edghill, E.L., Misovicova, N., Gasperikova, D., Sandrikova, V., Elliott, K.S., Barak, L., Ellard, S., Volpi, E.V., Klimes, I. and Gloyn, A.L. 2009. Severe insulin resistance and intrauterine growth deficiency associated with haploin sufficiency for INSR and CHN2: new insights into synergistic pathways involved in growth and metabolism. Diabetes. 58 (12), pp. 2954-2961. https://doi.org/10.2337/db09-0787

Secreted Frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer

Journal article

Kawano, Y., Diez, S., Uysal-Onganer, P., Darrington, R.S., Waxman, J. and Kypta, R.M. 2009. Secreted Frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer. British Journal of Cancer. 100, pp. 1165-1174. https://doi.org/10.1038/sj.bjc.6604976

The use of cardiovascular biomarkers for the assessment of heart disease in men

Book chapter

Gaze, D.C. 2009. The use of cardiovascular biomarkers for the assessment of heart disease in men. in: Heart Disease in Men Nova Science Publishers. pp. 167-182

Alterations in left ventricular function and cardiac biomarkers as a consequence of repetitive endurance cycling

Journal article

Williams, K., Gregson, W., Robertson, C., Datson, N., Whyte, G., Murrell, C., Wilson, L., Ainslie, P., Ross, E., Shave, R., Gaze, D.C. and George, K. 2009. Alterations in left ventricular function and cardiac biomarkers as a consequence of repetitive endurance cycling. European Journal of Sport Science. 9 (2), pp. 97-105. https://doi.org/10.1080/17461390902763391

Left ventricular wall segment motion after ultra-endurance exercise in humans assessed by myocardial speckle tracking

Journal article

George, K., Shave, R., Oxborough, D., Cable, T., Dawson, E., Artis, N., Gaze, D.C., Hew-Butler, T., Sharwood, K. and Noakes, T. 2009. Left ventricular wall segment motion after ultra-endurance exercise in humans assessed by myocardial speckle tracking. European Journal of Echocardiography. 10 (2), p. 238–243. https://doi.org/10.1093/ejechocard/jen207

Cardiovascular Consequences of Completing a 160-km Ultramarathon

Journal article

Scott, J.M., Esch, B.T., Shave, R., Warburton, D.E., Gaze, D.C. and George, K. 2009. Cardiovascular Consequences of Completing a 160-km Ultramarathon. Medicine and Science in Sports and Exercise. 41 (1), pp. 26-34. https://doi.org/10.1249/mss.0b013e31818313ff

Cardiac troponin elevations in patients presenting with emergency orthopaedic trauma

Journal article

Gaze, D.C. 2009. Cardiac troponin elevations in patients presenting with emergency orthopaedic trauma. Injury. 40 (3), p. 338. https://doi.org/10.1016/j.injury.2008.10.031

The diagnostic and prognostic value of tissue Doppler imaging during dobutamine stress echocardiography in end-stage renal disease

Article

Sharma, R., Mehta, R.L., Brecker, S.J.D., Gaze, D.C., Gregson, H., Streather, C.P., Collinson, P.O. and Pellerin, D. 2009. The diagnostic and prognostic value of tissue Doppler imaging during dobutamine stress echocardiography in end-stage renal disease. Coronary Artery Disease. 20 (3), pp. 230-237. https://doi.org/10.1097/mca.0b013e32832ac5eb

Assay imprecision and 99th-percentile reference value of a high-sensitivity cardiac troponin I assay

Journal article

Collinson, P.O., Clifford-Mobley, O., Gaze, D.C., Boa, F. and Senior, R. 2009. Assay imprecision and 99th-percentile reference value of a high-sensitivity cardiac troponin I assay. Clinical Chemistry. 55 (7), p. 1433–1434. https://doi.org/10.1373/clinchem.2009.124925

Rosiglitazone reduces the development and rupture of experimental aortic aneurysms

Journal article

Jones, A., Deb, R., Torsney, E., Howe, F., Dunkley, M., Gnaneswaran, Y., Gaze, D.C., Nasr, H., Loftus, I.M., Thompson, M.M. and Cockerill, G.W. 2009. Rosiglitazone reduces the development and rupture of experimental aortic aneurysms. Circulation. 119, p. 3125–3132. https://doi.org/10.1161/circulationaha.109.852467

Cardiac troponins in patients with renal failure. What are we measuring and when should we measure it?

Journal article

Collinson, P.O. and Gaze, D.C. 2009. Cardiac troponins in patients with renal failure. What are we measuring and when should we measure it? Annals of Clinical Biochemistry. 46 (4), pp. 269-270. https://doi.org/10.1258/acb.2009.009058

Ischemia Modified Albumin: A Novel Biomarker for the Detection of Cardiac Ischemia

Journal article

Gaze, D.C. 2009. Ischemia Modified Albumin: A Novel Biomarker for the Detection of Cardiac Ischemia. European Journal of Drug Metabolism and Pharmacokinetics. 24 (4), pp. 333-341. https://doi.org/10.2133/dmpk.24.333

Id1 promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signalling

Journal article

Wood, A.D., Chen, E., Donaldson, I.J., Hattangadi, S., Burke, K.A., Dawson, M.A., Miranda-Saavendra, D., Lodish, H.F., Green, A.R. and Gottgens, B. 2009. Id1 promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signalling. Blood. 114, pp. 1820-1830. https://doi.org/10.1182/blood-2009-02-206573

The use of cardiac markers for the assessment of heart disease in men

Book chapter

Gaze, D.C. 2009. The use of cardiac markers for the assessment of heart disease in men. in: Todd, A.B. and Mosley, M.H. (ed.) Heart Disease in Men New York Nova Science Publishers. pp. 167-182

PPARalpha deficiency impacts the regulation ofadipocyte leptin synthesis and secretion

Journal article

Holness, M.J., Zariwala, M., Walker, C.G. and Sugden, M.C. 2009. PPARalpha deficiency impacts the regulation ofadipocyte leptin synthesis and secretion. Diabetic Medicine. 26 (S1), pp. 37-38. https://doi.org/10.1111/j.1464-5491.2009.02662.x

The molecular regulation of adipose-tissue gene expression by an early life intervention

Journal article

Sugden, M.C., Zariwala, M., Nooristani, S. and Holness, M.J. 2009. The molecular regulation of adipose-tissue gene expression by an early life intervention. Diabetic Medicine. 26 (S1), pp. 37-38. https://doi.org/10.1111/j.1464-5491.2009.02662.x

Abrus Toxins: Study on a dangerous lectin duo present in the seeds of Indian licorice

Book

Surendranath, K. 2009. Abrus Toxins: Study on a dangerous lectin duo present in the seeds of Indian licorice. Germany Lambert Academic Publishing GmbH & Company KG.

Endoplasmic stress is induced by lipopolysaccharides and high glucose and is alleviated by salicylates in cultured primary human adipocytes

Conference item

Alhusaini, S., Lois, K., McGee, K.C., McTernan, P.G., Kumar, S. and Tripathi, G. 2009. Endoplasmic stress is induced by lipopolysaccharides and high glucose and is alleviated by salicylates in cultured primary human adipocytes. 45th EASD Annual Meeting of the European Association for the Study of Diabetes. Vienna, Austria 30 Sep - 02 Oct 2009 Springer. https://doi.org/10.1007/s00125-009-1445-1

A novel role for p53 in the regulation of oxidative stress in vascular cells in response to glucose fluctuation

Conference item

Schisano, B., Radford, C.R., Harte, A.L., Tripathi, G., McTernan, P.G. and Ceriello, A. 2009. A novel role for p53 in the regulation of oxidative stress in vascular cells in response to glucose fluctuation. 45th EASD Annual Meeting of the European Association for the Study of Diabetes. Vienna, Austria 30 Sep - 02 Oct 2009 Springer. https://doi.org/10.1007/s00125-009-1445-1

Acute and chronic saturated fatty acid treatment as a key instigator of the TLR mediated inflammatory response in human adipose tissue in vitro

Conference item

Harte, A.L., Youssef-Elabd, E.M., McGee, K.C., Tripathi, G., Abdalla, M.S., Sharada, H.M., Ashour, E., Amin, A.I., O’Hare, J.P., Kumar, S. and McTernan, P.G. 2009. Acute and chronic saturated fatty acid treatment as a key instigator of the TLR mediated inflammatory response in human adipose tissue in vitro. 45th General Assembly of the European Association for the Study of Diabetes. Messe Wien, Vienna, Austria 03 Sep - 02 Oct 2009 Springer. https://doi.org/10.1007/s00125-010-1872-z

Metabolic endotoxaemia as a mediator of mitochondrial dysfunction in human adipose tissue, alleviated by salicylate

Conference item

McGee, K.C., Tripathi, G., Creely,S.J., Harte, A.L., Langowska, M., Da Silva, N.F., Brown, A., Oscarsson, J., Clapham, J.C., Kumar, S. and McTernan, P.G. 2009. Metabolic endotoxaemia as a mediator of mitochondrial dysfunction in human adipose tissue, alleviated by salicylate. 45th General Assembly of the European Association for the Study of Diabetes. Messe Wien, Vienna, Austria 30 Sep - 02 Oct 2009 Springer. https://doi.org/10.1007/s00125-010-1872-z

Endoplasmic reticulum stress induced by hyperglycaemia and saturated fatty acids is alleviated by salicylates in cultured primary human adipocytes

Conference item

Langowska, M., Alhusaini, S., McGee, K.C., Harte, A.L., McTernan, P.G., Kumar, S. and Tripathi, G. 2009. Endoplasmic reticulum stress induced by hyperglycaemia and saturated fatty acids is alleviated by salicylates in cultured primary human adipocytes. 45th General Assembly of the European Association for the Study of Diabetes. Messe Wien, Vienna, Austria 30 Sep - 02 Oct 2009 Springer. https://doi.org/10.1007/s00125-010-1872-z

Liraglutide down regulates endoplasmic reticulum stress in human endothelial cells exposed to hyperglycaemia

Conference item

Schisano, B., Tripathi, G., Harte, A.L., McTernan, P.G., Knusden, L. and Ceriello, A. 2009. Liraglutide down regulates endoplasmic reticulum stress in human endothelial cells exposed to hyperglycaemia. 45th General Assembly of the European Association for the Study of Diabetes. Messe Wien, Vienna, Austria 30 Sep - 02 Oct 2009 Springer. https://doi.org/10.1007/s00125-010-1872-z

IGF-independent effects of insulin-like growth factor binding protein-5 (Igfbp5) in vivo

Article

Tripathi, G., Salih, D.A.M., Drozd, A.C., Cosgrove, R.A., Cobb, L.C. and Pell, J.M. 2009. IGF-independent effects of insulin-like growth factor binding protein-5 (Igfbp5) in vivo. FASEB Journal. 23 (8), pp. 2616-2626. https://doi.org/10.1096/fj.08-114124

PPARs and the orchestration of metabolic fuel selection

Article

Sugden, M.C., Zariwala, M.G. and Holness, M.J. 2009. PPARs and the orchestration of metabolic fuel selection. Pharmacological Research. 60 (3), p. 141–150. https://doi.org/10.1016/j.phrs.2009.03.014

Impact of selection and demography on the diffusion of lactase persistence

Journal article

Gerbault, P., Moret, C., Currat, M. and Sanchez-Mazas, A. 2009. Impact of selection and demography on the diffusion of lactase persistence. PLoS ONE. 4 (7) e6369. https://doi.org/10.1371/journal.pone.0006369

Changes in progenitor populations and ongoing neurogenesis in the regenerating chick spinal cord

Article

Lange, S., Whalley, K., Gogel, S. and Ferretti, P. 2009. Changes in progenitor populations and ongoing neurogenesis in the regenerating chick spinal cord. Developmental Biology. 332 (2), p. 234–245. https://doi.org/10.1016/j.ydbio.2009.05.569

Post-transcriptional regulator protein ZFP36L1 targeting of Bcl-2 mRNA

Conference paper

Zekavati, A., Marsh, P. and Murphy, J.J. 2009. Post-transcriptional regulator protein ZFP36L1 targeting of Bcl-2 mRNA. 2nd European Congress of Immunology. Berlin, Germany 13 – 16 September 2009

Evaluation of community level interventions to address social and structural determinants of health: a cluster randomised controlled trial

Article

Wall, M., Hayes, R., Moore, D.G., Pettigrew, M., Clow, A., Schmidt, E., Draper, A., Lock, K., Lynch, R. and Renton, A. 2009. Evaluation of community level interventions to address social and structural determinants of health: a cluster randomised controlled trial. BMC Public Health. 9 (207), p. 1. https://doi.org/10.1186/1471-2458-9-207

Sound science and environmental monitoring: a case study of pharmaceuticals in aquatic environments

Conference paper

Walker, S. and McEldowney, S. 2009. Sound science and environmental monitoring: a case study of pharmaceuticals in aquatic environments. William Smith meeting: environmental pollution and human health. London

Pharmaceuticals in water and regulatory concerns

Conference paper

Walker, S. and McEldowney, S. 2009. Pharmaceuticals in water and regulatory concerns. Society of environmental toxiocology and chemisty annual meeting: environment and human health. London


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