This paper presents results from the SESAR ER3 Domino project. It focuses on an ECAC-wide assessment of two 4D-adjustment mechanisms, implemented separately and conjointly. These reflect flight behaviour en-route and at-gate, optimising given (cost) objective functions. New metrics designed to capture network effects are used to analyse the results of a microscopic, agent based model. The results show that some implementations of the mechanisms allow the protection of the network from ‘domino’ effects. Airlines focusing on costs may trigger additional side-effects on passengers, displaying, in some instances, clear trade-offs between passenger- and flight-centric metrics.