Life Sciences

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HeadProf Alistair Mathie
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Biosynthesis of Poly-3-Hydroxybutyrate and its Application in Controlled Drug Delivery

PhD thesis

Puthussery, H. 2019. Biosynthesis of Poly-3-Hydroxybutyrate and its Application in Controlled Drug Delivery. PhD thesis University of Westminster School of Life Sciences https://doi.org/10.34737/q9xy6

Short-Term Exercise Training Inconsistently Influences Basel Testosterone in Older Men: A Systematic Review and Meta-Analysis

Journal article

Hayes, L. and Elliott, B. 2019. Short-Term Exercise Training Inconsistently Influences Basel Testosterone in Older Men: A Systematic Review and Meta-Analysis. Frontiers in Physiology. 9 1878. https://doi.org/10.3389/fphys.2018.01878

Biocatalytic electrode improvement strategies in microbial fuel cell systems

Journal article

Breheny, M., Bowman, K., Farahmand, N., Gomaa, O., Keshavarz, T. and Kyazze, G. 2019. Biocatalytic electrode improvement strategies in microbial fuel cell systems. Journal of Chemical Technology and Biotechnology. 94 (7), pp. 2081-2091. https://doi.org/10.1002/jctb.5916

Peptidylarginine Deiminases Post-translationally deiminate Prohibitin and modulate Extracellular Vesicle Release and microRNAs in Glioblastoma Multiforme

Journal article

Kosgodage, U., Uysal Onganer, P., Maclatchy, A., Kraev, I., Chatterton, N.P., Nicholas, A.P., Inal, J.M. and Lange, S. 2019. Peptidylarginine Deiminases Post-translationally deiminate Prohibitin and modulate Extracellular Vesicle Release and microRNAs in Glioblastoma Multiforme . International Journal of Molecular Sciences. 20 (1) 103. https://doi.org/10.3390/ijms20010103

A novel ladder-like lectin relates to sites of mucosal immunity in Atlantic Halibut (Hippoglossus hippoglossus L.)

Journal article

Magnadóttir, B., Gudmundsdottir, S. and Lange, S. 2019. A novel ladder-like lectin relates to sites of mucosal immunity in Atlantic Halibut (Hippoglossus hippoglossus L.) . Fish & Shellfish Immunology. 87, pp. 9-12. https://doi.org/10.1016/j.fsi.2018.12.034

Cannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cells

Journal article

Kosgodage, U., Uysal Onganer, P., Maclatchy, A., Mould, R., Nunn, A.V.W., Guy, G.W., Kraev, I., Chatterton, N.P., Thomas, E.L., Inal, J.M., Bell, J.D. and Lange, S. 2019. Cannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cells. Translational Oncology. 12 (3), pp. 513-522. https://doi.org/10.1016/j.tranon.2018.12.004

Buffering agents: Sodium Bicarbonate, Sodium Citrate, Sodium Phosphate

Book chapter

McNaughton, L., Brewer, C., Deb, S., Hilton, N., Gough, L. and Sparks, S.A. 2019. Buffering agents: Sodium Bicarbonate, Sodium Citrate, Sodium Phosphate. in: Hoffman, J. (ed.) Dietary Supplementation in Sport and Exercise: Evidence, Safety, and Ergogenic Benefits Routledge. pp. 191-205

Probing the mechanism of simultaneous bioenergy production and biodegradation process of Congo red in microbial fuel cells

Journal article

Gomaa, O.M., Fapetu, S.A., Kyazze, G. and Keshavarz, T. 2019. Probing the mechanism of simultaneous bioenergy production and biodegradation process of Congo red in microbial fuel cells. Journal of Chemical Technology and Biotechnology. 94 (7), pp. 2092-2097. https://doi.org/10.1002/jctb.5892

Draft Genome Sequences of Salmonella enterica subsp. enterica Serovar Dublin Strains from St. Nectaire and Morbier Cheeses Characterized by Multilocus Variable-Number Tandem-Repeat Analysis Profiles Associated with Two Fatal Outbreaks in France

Journal article

Six, S.C., Vignaud, M.L. and Mohammed, M. 2019. Draft Genome Sequences of Salmonella enterica subsp. enterica Serovar Dublin Strains from St. Nectaire and Morbier Cheeses Characterized by Multilocus Variable-Number Tandem-Repeat Analysis Profiles Associated with Two Fatal Outbreaks in France. Microbiology Resource Announcements. 8 (1) e01361-18. https://doi.org/10.1128/MRA.01361-18

Peptidylarginine deiminase and deiminated proteins are detected throughout early halibut ontogeny - Complement components C3 and C4 are post-translationally deiminated in halibut (Hippoglossus hippoglossus L.)

Journal article

Magnadóttir, B., Bragason, B.T., Bricknell, I.R., Bowden, T., Nicholas, A.P., Hristova, M., Gudmundsdottir, S., Dodds, A.W. and Lange, S. 2019. Peptidylarginine deiminase and deiminated proteins are detected throughout early halibut ontogeny - Complement components C3 and C4 are post-translationally deiminated in halibut (Hippoglossus hippoglossus L.). Developmental and Comparative Immunology. 92, pp. 1-19. https://doi.org/10.1016/j.dci.2018.10.016

The roles of social media, clean eating and self-esteem in the risk of disordered eating: A pilot study of self-reported healthy eaters

Journal article

Fivian, E. and Wood, C. 2019. The roles of social media, clean eating and self-esteem in the risk of disordered eating: A pilot study of self-reported healthy eaters. International Journal of Food, Nutrition and Public Health. 10 (1), pp. 28-39.

Genome-wide and abdominal MRI-imaging data provides evidence that a genetically determined favourable adiposity phenotype is characterized by lower ectopic liver fat and lower risk of type 2 diabetes, heart disease and hypertension

Journal article

Ji, Y., Yiorkas, A.M., Frau, F., Mook-Kanamori, D., Staiger, H., Thomas, E.L., Atabaki-Pasdar, N., Campbell, A., Tyrrell, J., Jones, S.E., Beaumont, R.N., Wood, A.R., Tuke, M.A., Ruth, K.S., Mahajan, A., Murray, A., Freathy, R.M., Weedon, M.N., Hattersley, A.T., Hayward, C., Machann, J., Häring, H.U., Franks, P.W., de Mutsert, R., Pearson, E., Stefan, N., Frayling, T.M., Allebrandt, K.V., Bell, J.D., Blakemore, A.I. and Yaghootkar, H. 2019. Genome-wide and abdominal MRI-imaging data provides evidence that a genetically determined favourable adiposity phenotype is characterized by lower ectopic liver fat and lower risk of type 2 diabetes, heart disease and hypertension. Diabetes. 68 (1), pp. 207-219. https://doi.org/10.2337/db18-0708

Spatiotemporal dynamics of PDGFRβ expression in pericytes and glial scar formation in penetrating brain injuries in adults

Journal article

Reeves, C., Jardim, A.P., Sisodiya, S.M., Thom, M. and Liu, J. 2019. Spatiotemporal dynamics of PDGFRβ expression in pericytes and glial scar formation in penetrating brain injuries in adults. Neuropathology and Applied Neurobiology. 45 (6), pp. 609-627 NAN-2018-0107.R1. https://doi.org/10.1111/nan.12539

The use of bio-electrochemical systems in environmental remediation of xenobiotics: a review

Journal article

Fernando, E., Keshavarz, T. and Kyazze, G. 2019. The use of bio-electrochemical systems in environmental remediation of xenobiotics: a review. Journal of Chemical Technology and Biotechnology. 94 (7), pp. 2070-2080. https://doi.org/10.1002/jctb.5848

The effects of dietary supplementation with inulin and inulin-propionate ester on hepatic steatosis in adults with non-alcoholic fatty liver disease

Journal article

Chambers, E.S., Byrne, C.S., Rugyendo, A., Morrison, D.J., Preston, T., Tedford, M.C., Bell, J.D., Thomas, E.L., Akbar, A.N., Riddell, N.E., Sharma, R., Thursz, M.R., Manousou, P. and Frost, G. 2019. The effects of dietary supplementation with inulin and inulin-propionate ester on hepatic steatosis in adults with non-alcoholic fatty liver disease. Diabetes, Obesity and Metabolism. 21 (2), pp. 372-376. https://doi.org/10.1111/dom.13500

Reference range of liver corrected T1 values in a population at low risk for fatty liver disease-a UK Biobank sub-study, with an appendix of interesting cases

Journal article

Mojtahed, A., Kelly, C.J., Herlihy, A.H., Kin, S., Wilman, H.R., McKay, A., Kelly, M., Milanesi, M., Neubauer, S,, Thomas, E.L., Bell, J.D., Banerjee, R. and Harisinghani, M. 2019. Reference range of liver corrected T1 values in a population at low risk for fatty liver disease-a UK Biobank sub-study, with an appendix of interesting cases. Abdominal Radiology. 44 (1), pp. 72-84. https://doi.org/10.1007/s00261-018-1701-2

Development of Measure Yourself Concerns and Wellbeing for informal caregivers of people with cancer – a multicentred study

Journal article

Jolliffe, R., Collaco, N., Seers, H., Farrell, C., Sawkins, M.J. and Polley, M.J. 2019. Development of Measure Yourself Concerns and Wellbeing for informal caregivers of people with cancer – a multicentred study. Supportive Care in Cancer. 27 (5), pp. 1901-1909. https://doi.org/10.1007/s00520-018-4422-8

Quality Control of Hypericum perforatum L. Analytical challenges and recent progress

Journal article

Agapouda, A., Booker, A., Kiss, T., Hohmann, J., Heinrich, M. and Csupor, D. 2019. Quality Control of Hypericum perforatum L. Analytical challenges and recent progress. Journal of Pharmacy and Pharmacology. 71 (1), pp. 15-37. https://doi.org/10.1111/jphp.12711

Evidence of chemotherapy-induced bystander effect and a potential involvement of reactive oxygen species in an in vitro co-culture model

Article

Okeke, K., Conway, M. and Morse, R. 2018. Evidence of chemotherapy-induced bystander effect and a potential involvement of reactive oxygen species in an in vitro co-culture model. Mutagenesis. 33 (5-6), pp. 392-393. https://doi.org/10.1093/mutage/gey033

GI-530159, a novel, selective, mechano-sensitive K2P channel opener, reduces rat dorsal root ganglion (DRG) neuron excitability

Journal article

Alexandre J.C. Loucif, Pierre-Philippe Saintot, Jia Liu, Brett M. Antonio, Shannon G. Zellmer, Katrina Yoger, Emma L. Veale, Anna Wilbrey, Kiyoyuki Omoto, Lishuang Cao, Alex Gutteridge, Neil A. Castle, Edward B. Stevens and Alistair Mathie 2018. GI-530159, a novel, selective, mechano-sensitive K2P channel opener, reduces rat dorsal root ganglion (DRG) neuron excitability. British Journal of Pharmacology. 175 (12), pp. 2272-2283. https://doi.org/10.1111/bph.14098

HIV transgene expression impairs K+ channel function in the pulmonary vasculature

Journal article

Mondejar-Parreño, G., Morales-Cano, D., Barreira, B., Callejo, M., Ruiz-Cabello, J., Moreno, L., Esquivel-Ruiz, S., Mathie, A., Butrous, G., Perez-Vizcaino, F. and Cogolludo, A. 2018. HIV transgene expression impairs K+ channel function in the pulmonary vasculature. American Journal of Physiology: Lung and Molecular Physiology. 315 (5), pp. L711-L723. https://doi.org/10.1152/ajplung.00045.2018

Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons.

Journal article

Fernández-Fernández, D., Cadaveira-Mosquera, A., Rueda-Ruzafa, L., Herrera-Pérez, S., Veale, E.L., Reboreda, A., Mathie, A. and Lamas, J.A. 2018. Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons. PLoS ONE. 13 (6) e0199282. https://doi.org/10.1371/journal.pone.0199282

Pharmacists detecting atrial fibrillation (PDAF) in primary care during the influenza vaccination season: a multisite, cross-sectional screening protocol

Article

Emma L Veale, Adrian J Stewart, Alistair Mathie, Satvinder K Lall, Melanie Rees-Roberts, Vilius Savickas, Sukvinder K Bhamra and Sarah A Corlett 2018. Pharmacists detecting atrial fibrillation (PDAF) in primary care during the influenza vaccination season: a multisite, cross-sectional screening protocol. BMJ Open. 8 (3) e021121. https://doi.org/10.1136/bmjopen-2017-021121

Multiscale Analysis of Microvascular Blood Flow and Oxygenation

Conference paper

Thanaj, M., Chipperfield, A.J. and Clough, G.F. 2018. Multiscale Analysis of Microvascular Blood Flow and Oxygenation. World Congress on Medical Physics and Biomedical Engineering 2018. Prague, Czech Republic 03 - 08 Jun 2018 Springer. https://doi.org/10.1007/978-981-10-9038-7_36

Analysis of microvascular blood flow and oxygenation: Discrimination between two haemodynamic steady states using nonlinear measures and multiscale analysis

Journal article

Thanaj, M., Chipperfield, A.J. and Clough, G.F. 2018. Analysis of microvascular blood flow and oxygenation: Discrimination between two haemodynamic steady states using nonlinear measures and multiscale analysis. Computers in Biology and Medicine. 102, pp. 157-167. https://doi.org/10.1016/j.compbiomed.2018.09.026

Efficacy of co-supplementation therapy with vitamins B9, B12, and D on endothelial dysfunction in streptozotocin-induced diabetic rats

Journal article

Al-Joufi, F., El-Bana, M., Tewfik, I. and Anwar, M. 2018. Efficacy of co-supplementation therapy with vitamins B9, B12, and D on endothelial dysfunction in streptozotocin-induced diabetic rats. Asian Journal of Pharmaceutical and Clinical Research . 11 (9), pp. 407-410. https://doi.org/10.22159/ajpcr.2018.v11i9.25361

Genome-Wide and Abdominal Imaging Data Characterizes Common Alleles Associated with Higher BMI and Subcutaneous Fat but Less Liver Fat and Lower Risk of Type 2 Diabetes

Article

Yaghootkar, Hanieh, Ji, Yingjie, Yiorkas, Andrianos M., Frau, Francesca, Mook-Kanamori, Dennis, De Mutsert, Renee, Tyrrell, Jessica, Jones, Samuel E., Beaumont, Robert, Wood, Andrew R., Thomas, Louise, Allebrandt, Karla V., Stefan, Norbert, Staiger, Harald, Pearson, Ewan, Blakemore, Alex I., Bell, Jimmy D. and Frayling, Timothy M. 2018. Genome-Wide and Abdominal Imaging Data Characterizes Common Alleles Associated with Higher BMI and Subcutaneous Fat but Less Liver Fat and Lower Risk of Type 2 Diabetes. Diabetes. 67 (Supplement 1), pp. 20-OR. https://doi.org/10.2337/db18-20-or

The effects of a three-week restricted carbohydrate diet on exercise metabolism and performance of three cyclists

Journal article

Hough, P. 2018. The effects of a three-week restricted carbohydrate diet on exercise metabolism and performance of three cyclists. Trends in Sport Sciences. 3 (25), pp. 117-125. https://doi.org/10.23829/TSS.2018.25.3-1

Immunity levels to poliovirus in Lao children and adults before the vaccine-derived poliovirus outbreak: A retrospective study

Journal article

Pauly, Maude, Black, Antony P., Khampanisong, Phonepaseuth, Nouanthong, Phonethipsavanh, Hübschen, Judith M, Nanthavong, Naphavanh, Sayasinh, Kong, Jutavijittum, Prapan, Samountry, Bounthome, Xeuatvongsa, Anonh, Diedrich, Sabine and Muller, Claude P. 2018. Immunity levels to poliovirus in Lao children and adults before the vaccine-derived poliovirus outbreak: A retrospective study. PLoS ONE. 13 (5) e0197370. https://doi.org/10.1371/journal.pone.0197370

High circulation of hepatitis E virus in pigs and professionals exposed to pigs in Laos

Journal article

Khounvisith, Vilaysone, Tritz, Silvia, Khenkha, Latdavone, Phoutana, Vannaphone, Keosengthong, Amphone, Pommasichan, Sisavath, Nouanthong, Phonethipsavanh, Hübschen, Judith M, Snoeck, Chantal J, Reinharz, Daniel, Muller, Claude P., Black, Antony P. and Pauly, Maude 2018. High circulation of hepatitis E virus in pigs and professionals exposed to pigs in Laos. Zoonoses and Public Health. 65 (8), pp. 1020-1026. https://doi.org/10.1111/zph.12520

Selenium deficiency and pregnancy outcome in pregnant women with HIV in Lagos, Nigeria

Journal article

Okunade, K.S., Olowoselu, O.F., Osanyin, G.E., John-Olabode, S., Akanmu, S.A. and Anorlu, R.I. 2018. Selenium deficiency and pregnancy outcome in pregnant women with HIV in Lagos, Nigeria. International Journal of Gynecology & Obstetrics. 142 (2), pp. 207-213. https://doi.org/10.1002/ijgo.12508

Evidence of increased Hepatitis E virus exposure in Lao villagers with contact to ruminants

Journal article

Tritz, Silvia E, Khounvisith, Vilaysone, Pommasichan, Sisavath, Ninnasopha, Khampasong, Keosengthong, Amphone, Phoutana, Vannaphone, Camoin, Margot, Hübschen, Judith M, Black, A., Muller, Claude P and others 2018. Evidence of increased Hepatitis E virus exposure in Lao villagers with contact to ruminants. Zoonoses and public health. 65 (6), pp. 690-701. https://doi.org/10.1111/zph.12483

Seroprevalence and risk factors of hepatitis B and C virus infections in female workers of Lao garment factories

Journal article

Xaydalasouk, Kinnaly, Strobel, Michel, Buisson, Yves, Black, A. and Muller, Claude P 2018. Seroprevalence and risk factors of hepatitis B and C virus infections in female workers of Lao garment factories. PLoS ONE. https://doi.org/10.1371/journal.pone.0199919

MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure

Journal article

Triantafyllou, E., Pop, O.T., Possamai, L.A., Wilhelm, A., Liaskou, E., Singanayagam, A., Bernsmeier, C., Khamri, W., Petts, G., Dargue, R., Davies, S.P., Tickle, J., Yuksel, M., Patel, V.C., Abeles, R.D., Stamataki, Z., Curbishley, S.M., Ma, Y., Wilson, I.D., Coen, M., Woollard, K.J., Quaglia, A., Wendon, J., Thursz, M.R., Adams, D.H., Weston, C.J. and Antoniades, C.G. 2018. MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure. Gut. 67, pp. 333-347. https://doi.org/10.1136/gutjnl-2016-313615

The induction of autoimmune hepatitis in the human leucocyte antigen-DR4 non-obese diabetic mice autoimmune hepatitis mouse model

Journal article

Yuksel, M., Xiao, X., Tai, N., Vijay, G.M., Gülden, E., Beland, K., Lapierre, P., Alvarez, F., Hu, Z., Colle, I., Ma, Y. and Wen, L. 2018. The induction of autoimmune hepatitis in the human leucocyte antigen-DR4 non-obese diabetic mice autoimmune hepatitis mouse model. Clinical and Experimental Immunology. 192 (1), pp. 164-176. https://doi.org/10.1111/cei.12843

The evolutionary landscape of colorectal tumorigenesis

Journal article

William Cross, Michal Kovac, Ville Mustonen, Daniel Temko, Hayley Davis, Ann-Marie Baker, Sujata Biswas, Roland Arnold, Laura Chegwidden, Chandler Gatenbee, Alexander R.A. Anderson, Viktor Koelzer, Pierre Martinez, Xiaowei Jiang, Enric Domingo, Dan J. Woodcock, Yun Feng, Monika Kovacova, Tim Maughan, Richard Adams, Simon Bach, Andrew Beggs, Louise Brown, Francesca Buffa, Jean-Baptiste Cazier, Enric Domingo, Andrew Blake, Che-Hsi Wu, Ekaterina Chatzpili, Susan Richman, Philip Dunne, Paul Harkin, Geoff Higgins, Jim Hill, Chris Holmes, Denis Horgan, Rick Kaplan, Richard Kennedy, Mark Lawler, Simon Leedham, Tim Maughan, Ultan McDermott, Gillies McKenna, Gary Middleton, Dion Morton, Graeme Murray, Phil Quirke, Manuel Salto-Tellez, Les Samuel, Anna Schuh and David Sebag-Montefiore 2018. The evolutionary landscape of colorectal tumorigenesis. Nature Ecology & Evolution. 2, pp. 1661-1672. https://doi.org/10.1038/s41559-018-0642-z

Bolus ingestion of whey protein immediately post-exercise does not influence rehydration compared to energy-matched carbohydrate ingestion

Journal article

Evans, G.H., Mattin, L.R., Ireland, I., Harrison, W., Yau, A.M.W., McIver, V., Pocock, T., Sheader, E. and James, L.J. 2018. Bolus ingestion of whey protein immediately post-exercise does not influence rehydration compared to energy-matched carbohydrate ingestion. Nutrients. 10 (6) 769. https://doi.org/10.3390/nu10060769

The effect of exercise intensity on gastric emptying rate, appetite and gut derived hormone responses after consuming a standardised semi-solid meal in healthy males

Journal article

Mattin, L.R., Yau, A.M.W., McIver, V., James, L.J. and Evans, G.H. 2018. The effect of exercise intensity on gastric emptying rate, appetite and gut derived hormone responses after consuming a standardised semi-solid meal in healthy males. Nutrients. 10 (6) 787. https://doi.org/10.3390/nu10060787

Improved reference genome of Aedes aegypti informs arbovirus vector control.

Journal article

Matthews, B.J., Dudchenko, O., Kingan, S.B., Koren, S., Antoshechkin, I., Crawford, J.E., Glassford, W.J., Herre, M., Redmond, S.N., Rose, N.H., Weedall, G.D., Wu, Y., Batra, S.S., Vosshall, L.B. and Partridge, F. 2018. Improved reference genome of Aedes aegypti informs arbovirus vector control. Nature. 563, pp. 501-507. https://doi.org/10.1038/s41586-018-0692-z

The fungal alkaloid Okaramine-B activates an L-glutamate-gated chloride channel from Ixodes scapularis, a tick vector of Lyme disease

Journal article

Furutani, S., Ihara, M., Lees, K., Buckingham, S.D., Partridge, F.A., David, J.A., Patel, R., Warchal, S., Mellor, I.R., Matsuda, K. and Sattelle, D.B. 2018. The fungal alkaloid Okaramine-B activates an L-glutamate-gated chloride channel from Ixodes scapularis, a tick vector of Lyme disease. International Journal for Parasitology: Drugs and Drug Resistance. 8 (2), pp. 350-360. https://doi.org/10.1016/j.ijpddr.2018.06.001


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