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HeadProf Alistair Mathie
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A novel "humanized mouse" model for autoimmune hepatitis and the association of gut microbiota with liver inflammation

Journal article

Yuksel, M., Wang, Y., Tai, N., Peng, J., Guo, J., Beland, K., Lapierre, P., David, C., Alvarez, F., Colle, I., Yan, H., Mieli-Vergani, G., Vergani, D., Ma, Y. and Wen, L. 2015. A novel "humanized mouse" model for autoimmune hepatitis and the association of gut microbiota with liver inflammation. Hepatology. 62 (5), pp. 1536-1550. https://doi.org/10.1002/hep.27998

Impact of donation mode on the proportion and function of T lymphocytes in the liver

Journal article

Xystrakis, E., Yuksel, M., Lin, F., Huang, X., Pop, O.T., Quaglia, A., Heaton, N., Prachalias, A., Rela, M., Fuggle, S., Ma, Y. and Jassem, W. 2015. Impact of donation mode on the proportion and function of T lymphocytes in the liver. PLoS ONE. 10 (10) e0139791. https://doi.org/10.1371/journal.pone.0139791

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities

Journal article

Pulcini, Serena, Staines, Henry M., Lee, Andrew H., Shafik, Sarah H., Bouyer, Guillaume, Moore, Catherine M., Daley, Daniel A., Hoke, Matthew J., Altenhofen, Lindsey M., Painter, Heather J., Mu, Jianbing, Ferguson, David J.P., Llinás, Manuel, Martin, Rowena E., Fidock, David A., Cooper, Roland A. and Krishna, Sanjeev 2015. Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities. Scientific Reports. 5 14552. https://doi.org/10.1038/srep14552

Chemerin Regulates Crosstalk Between Adipocytes and Vascular Cells Through Nox

Journal article

Karla Bianca Neves, Aurelie Nguyen Dinh Cat, Rheure Alves Moreira Lopes, Francisco Jose Rios, Aikaterini Anagnostopoulou, Nubia Souza Lobato, Ana Maria de Oliveira, Rita C. Tostes, Augusto C. Montezano and Rhian M. Touyz 2015. Chemerin Regulates Crosstalk Between Adipocytes and Vascular Cells Through Nox. Hypertension. 66 (3), pp. 657-666. https://doi.org/10.1161/hypertensionaha.115.05616

PARK7/DJ-1 dysregulation by oxidative stress leads to magnesium deficiency: implications in degenerative and chronic diseases

Journal article

Martin Kolisek, Augusto C. Montezano, Gerhard Sponder, Aikaterini Anagnostopoulou, Juergen Vormann, Rhian M. Touyz and Joerg R. Aschenbach 2015. PARK7/DJ-1 dysregulation by oxidative stress leads to magnesium deficiency: implications in degenerative and chronic diseases. Clinical Science. 129 (12), pp. 1143-1150. https://doi.org/10.1042/cs20150355

A cautionary note in the interpretation of human papillomavirus E6 immunohistochemistry in focal cortical dysplasia

Article

Thom, M., Liu, J., Reeves, C., Stopps, V., Sisodiya, S.M. and Liu, J.Y.W. 2015. A cautionary note in the interpretation of human papillomavirus E6 immunohistochemistry in focal cortical dysplasia. Annals of Neurology. 77 (2), pp. 352-353. https://doi.org/10.1002/ana.24330

Single-dose serotonergic stimulation shows widespread effects on functional brain connectivity

Journal article

Klaassens, B.L., van Gorsel, H.C., Khalili-Mahani, N., van der Grond, J., Wyman, B.T., Whitcher, B., Rombouts, S.A.R.B. and van Gerven, J.M.A. 2015. Single-dose serotonergic stimulation shows widespread effects on functional brain connectivity. NeuroImage. 122, pp. 440-450. https://doi.org/10.1016/j.neuroimage.2015.08.012

The cortical thickness phenotype of individuals with DISC1 translocation resembles schizophrenia

Journal article

Doyle, O.M., Bois, C., Thomson, P., Romaniuk, L., Whitcher, B., Williams, S.C.R., Turkheimer, F.E., Stefansson, H., McIntosh, A.M., Mehta, M.A. and Lawrie, S.M. 2015. The cortical thickness phenotype of individuals with DISC1 translocation resembles schizophrenia. Journal of Clinical Investigation. 125 (9), pp. 3714-3722. https://doi.org/10.1172/jci82636

Effects of a balanced translocation between chromosomes 1 and 11 disrupting the DISC1 locus on white matter integrity

Journal article

Whalley, H.C., Dimitrova, R., Sprooten, E., Dauvermann, M.R., Romaniuk, L., Duff, B., Watson, A.R., Moorhead, B., Bastin, M., Semple, S.I., Giles, S., Hall, J., Thomson, P., Roberts, N., Hughes, Z.A., Brandon, N.J., Dunlop, J., Whitcher, B., Blackwood, D.H.R., McIntosh, A.M. and Lawrie, S.M. 2015. Effects of a balanced translocation between chromosomes 1 and 11 disrupting the DISC1 locus on white matter integrity. PLoS ONE. 10 (6) e0130900. https://doi.org/10.1371/journal.pone.0130900

Betaine: Chemistry, Analysis, Function and Effects (Food and Nutritional Components in Focus)

Book

Patel, V.B and Preedy, V.R. Patel, V.B. and Preedy, V.R. (ed.) 2015. Betaine: Chemistry, Analysis, Function and Effects (Food and Nutritional Components in Focus). Royal Society of Chemistry.

Molecular effects of alcohol on iron metabolism

Book chapter

Mehta, K., Farnaud, S. and Patel, V.B. 2015. Molecular effects of alcohol on iron metabolism . in: Patel, V.B. (ed.) Molecular Aspects of Alcohol and Nutrition Academic Press.

Alcohol Metabolism: General Aspects

Book chapter

Ghazali, R. and Patel, V.B. 2015. Alcohol Metabolism: General Aspects. in: Patel, V.B. (ed.) Molecular Aspects of Alcohol and Nutrition Academic Press.

The measurement of physical activity behaviours of young people

Conference paper

Khawaja, I., Safi, A., Collins, P., Nevill, A. and Woodfield, L. 2015. The measurement of physical activity behaviours of young people. International Society of Behavioural Nutrition and Physical Activity Annual Conference 2015. Edinburgh International Conference Centre, Edinburgh, Scotland 03 - 06 Jun 2015

GEVACT: Genomic Variant Classifier Tool

Conference paper

Daneels, D., Grau, I., Sengupta, D., Bonduelle, M., Farid, D.M., Croes, D., Nowé, A. and Van Dooren, S. 2015. GEVACT: Genomic Variant Classifier Tool. BeSHG & NVHG First Joint Meeting “Genetics & Society”. Leuven, Belgium 04 - 05 Feb 2016

CliniPhenome: Clinical and Phenotypic Annotation Database

Conference paper

Sengupta, D., Croes, D., Van Dooren, S., Bonduelle, M. and Nowe, A. 2015. CliniPhenome: Clinical and Phenotypic Annotation Database. BeMGI Annual Meeting 2015. Ghent, Belgium

GeVaCT: Genomic Variant Classifier Tool

Conference paper

Grau, I., Daneels, D., Van Dooren, S., Bonduelle , M., Farid, D.M., Croes, D., Nowé, A. and Sengupta, D. 2015. GeVaCT: Genomic Variant Classifier Tool. 10th Benelux Bioinformatics Conference. University of Antwerp, Belgium 07 - 08 Dec 2015

CliniPhenome: Clinical and Phenotypic Annotation Database

Conference paper

Sengupta, D., Croes, D., Van Dooren, S., Bonduelle, M. and Nowe, A. 2015. CliniPhenome: Clinical and Phenotypic Annotation Database. 2nd International Conference on Health Informatics & Technology. Valencia, Spain 27 - 29 Jul 2015 OMICS Publishing Group.

Cutting Edge: Lessons from fraxinus, a crowd-sourced citizen science game in genomics

Journal article

Rallapalli, G., Players, F., Saunders, D.G., Yoshida, K., Edwards, A., Lugo, C.A., Collin, S., Clavijo, B., Corpas, M., Swarbreck, D., Clark, M., Downie, J.A., Kamoun, S., Cooper, T. and Maclean, D. 2015. Cutting Edge: Lessons from fraxinus, a crowd-sourced citizen science game in genomics. eLife. 4 e07460. https://doi.org/10.7554/elife.07460

GOBLET: The Global Organisation for Bioinformatics Learning, Education and Training

Journal article

Atwood, T.K., Bongcam-Rudloff, E., Brazas, M.E., Corpas, M., Gaudet, P., Lewitter, F., Mulder, N., Palagi, P.M., Schneider, M.V., van Gelder, C.W.G., Attwood, T.K., Banag, C., Blackford, S., Blatter, M.C., Bongcam-Rudloff, E., Brazas, M.D., Brooksbank, C., Budd, A., Charleston, M., Christoffels, A., Conesa, A., Crowe, M., Davies, A., de Crecy-Lagard, V., De Las Rivas, J., Doyle, M., Edwards, R., Facchiano, A., Fernandes, P., Gaeta, B., Gaudet, P., Heger, A., Herringa, J., Hughes, D., Jimenez, R.C., Kille, P., Korpelainen, E., Kumuthini, J., Lewitter, F., MacLean, D., Martinez, S.A.R., McGrath, A., Michalopoulos, I., Mulder, N., Ouellette, B.F., Palagi, P.M., Pearson, W.R., Qi, W., Romano, P., Rother, K., Sansone, S-A., Schneider, M.V., Schönbach, C., Tastan-Bishop, O., Trelles, O., Twells, R., van Gelder, C.W.G., Via, A., Vriend, G., Warnow, T., Watson, M., Westervelt, N. and Zanzoni, A. 2015. GOBLET: The Global Organisation for Bioinformatics Learning, Education and Training. PLOS Computational Biology. 11 (5) e1004281. https://doi.org/10.1371/journal.pcbi.1004143

Crowdsourced direct-to-consumer genomic analysis of a family quartet

Journal article

Corpas, M., Valdivia-Granda, W., Torres, N., Greshake, B., Coletta, A., Knaus, A., Harrison, A.P., Cariaso, M., Moran, F., Nielsen, F., Swan, D., Weiss Solís, D.Y., Krawitz, P., Schacherer, F., Schols, P., Yang, H., Borry, P., Glusman, G. and Robinson, P.N. 2015. Crowdsourced direct-to-consumer genomic analysis of a family quartet. BMC Genomics. 16 910. https://doi.org/10.1186/s12864-015-1973-7

A Quick Guide for Building a Successful Bioinformatics Community

Journal article

Budd, A., Corpas, M., Brazas, M.D., Fuller, J.C., Goecks, J., Mulder, N.J., Michaut, M., Ouellette, B.F.F., Pawlik, A. and Blomberg, N. 2015. A Quick Guide for Building a Successful Bioinformatics Community. PLOS Computational Biology. 11 (2) e1003972. https://doi.org/10.1371/journal.pcbi.1003972

The GOBLET training portal: A global repository of bioinformatics training materials, courses and trainers

Journal article

Corpas, M., Jimenez, R.C., Bongcam-Rudloff, E., Budd, A., Brazas, M.D., Fernandes, P.L., Gaeta, B., Van Gelder, C., Korpelainen, E., Lewitter, F., McGrath, A., MacLean, D., Palagi, P.M., Rother, K., Taylor, J., Via, A., Watson, M., Schneider, M.V. and Attwood, T.K. 2015. The GOBLET training portal: A global repository of bioinformatics training materials, courses and trainers. Bioinformatics. 31 (1), pp. 140-142. https://doi.org/10.1093/bioinformatics/btu601

Ten Simple Rules for Organizing an Unconference

Edited issue

Budd, A., Dinkel, H., Corpas, M., Fuller, J.C., Rubinat, L., Devos, D.P., Khoueiry, P.H., Förstner, K.U., Georgatos, F., Rowland, F., Sharan, M., Binder, J.X., Grace, T., Traphagen, K., Gristwood, A. and Wood, N.T. 2015. Ten Simple Rules for Organizing an Unconference. PLOS Computational Biology. 11 (1) e1003905. https://doi.org/10.1371/journal.pcbi.1003905

Future opportunities and trends for e-infrastructures and life sciences: Going beyond the grid to enable life science data analysis

Journal article

Duarte, A.M.S., Psomopoulos, F.E., Blanchet, C., Bonvin, A.M.J.J., Corpas, M., Franc, A., Jimenez, R.C., de Lucas, J.M., Nyrönen, T., Sipos, G. and Suhr, S.B. 2015. Future opportunities and trends for e-infrastructures and life sciences: Going beyond the grid to enable life science data analysis. Frontiers in Genetics. 6 197. https://doi.org/10.3389/fgene.2015.00197

Anatomy of BioJS, an open source community for the life sciences

Journal article

Yachdav, G., Goldberg, T., Wilzbach, S., Dao, D., Shih, I., Choudhary, S., Crouch, S., Franz, M., García, A., García, L.J., Grüning, B.A., Inupakutika, D., Sillitoe, I., Thanki, A.S., Vieira, B., Villaveces, J.M., Schneider, M.V., Lewis, S., Pettifer, S., Rost, B. and Corpas, M. 2015. Anatomy of BioJS, an open source community for the life sciences. eLife. 2015;4 e07009. https://doi.org/10.7554/elife.07009.001

A quick guide for building a successful bioinformatics community

Journal article

Budd, A., Corpas, M., Brazas, M.D., Fuller, J.C., Goecks, J., Mulder, N.J., Michaut, M., Ouellette, B.F.F., Pawlik, A. and Blomberg, N. 2015. A quick guide for building a successful bioinformatics community. PLOS Computational Biology. 11 (2) e1003972. https://doi.org/10.1371/journal.pcbi.1003972

The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection

Journal article

Torraca, V., Cui, Chao, Boland, Ralf, Bebelman, Jan-Paul, van der Sar, Astrid M., Smit, Martine J., Siderius, Marco, Spaink, Herman P. and Meijer, Annemarie H. 2015. The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection. Disease Models and Mechanisms. 8 (3), pp. 253-269. https://doi.org/10.1242/dmm.017756

Obesity: Subclinical cardiac damage and heart failure

Journal article

Gaze, D.C. 2015. Obesity: Subclinical cardiac damage and heart failure. Annals of Clinical Biochemistry. 52 (2), p. 302. https://doi.org/10.1177/0004563215570547

Preclinical detection of infectivity and disease-specific PrP in blood throughout the incubation period of prion disease

Journal article

Sawyer, E.B., Edgeworth, J.A., Thomas, C., Collinge, J. and Jackson, G.S. 2015. Preclinical detection of infectivity and disease-specific PrP in blood throughout the incubation period of prion disease. Scientific Reports. 5 17742. https://doi.org/10.1038/srep17742

Nerve tissue engineering using blends of poly(3-hydroxyalkanoates) for peripheral nerve regeneration

Journal article

Lizarraga Valderrama, L., Nigmatullin, R., Taylor, C., Haycock, J.W., Claeyssens, F., Knowles, J.C. and Roy, I. 2015. Nerve tissue engineering using blends of poly(3-hydroxyalkanoates) for peripheral nerve regeneration. Engineering in Life Sciences. 15 (6), pp. 612-621. https://doi.org/10.1002/elsc.201400151

Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice combine to promote disease progression in myeloproliferative neoplasms

Journal article

Chen, E., Schneider, R.K., Breyfogle, L.J., Rosen, E.A., Poveromo, L., Elf, S., Ko, A., Brumme, K., Levine, R., Ebert, B.L. and Mullally, A. 2015. Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice combine to promote disease progression in myeloproliferative neoplasms. Blood. 125, pp. 327-335. https://doi.org/10.1182/blood-2014-04-567024

Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms

Journal article

Tapper, W., Jones, A.V., Kralovics, R., Harutyunyan, A.S., Zoi, K., Leung, W., Godfrey, A.L., Guglielmelli, P., Callaway, A., Ward, D., Aranaz, P., White, H.E., Waghorn, K., Lin, F., Chase, A., Baxter, E.J., Maclean, C., Nangalia, J., Chen, E., Evans, P., Short, M., Jack, A., Wallis, L., Oscier, D., Duncombe, A.S., Schuh, A., Mead, A.J., Griffiths, M., Ewing, J., Gale, R.E., Schnittger, S., Haferlach, T., Stegelmann, F., Dohner, K., Grallert, H., Strauch, K., Tanaka, T., Bandinelli, S., Giannopoulos, A., Pieri, L., Mannarelli, C., Gisslinger, H., Barosi, G., Cazzola, M., Reiter, A., Harrison, C., Campbell P., Green, A.R., Vannucchi, A. and Cross N.C. 2015. Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms. Nature Communications . 6 6691. https://doi.org/10.1038/ncomms7691

RECQL5 suppresses oncogenic JAK2-induced replication stress and genomic instability

Journal article

Chen, E., Ahn, J.S., Sykes, D.B., Breyfogle, L.J., Godfrey, A.L., Nangalia, J., Ko, A., DeAngelo, D.J., Green, A.R. and Mullally, A. 2015. RECQL5 suppresses oncogenic JAK2-induced replication stress and genomic instability. Cell Reports. 13, pp. 2345-2532. https://doi.org/10.1016/j.celrep.2015.11.037

Elevated γ-Glutamyltransferase and Erythrocyte Sedimentation Rate in Ischemic Stroke in Discordant Monozygotic Twin Study

Journal article

Vadgama, N., Gaze, D.C., Ranson, J., Hardy, J. and Nasir, J. 2015. Elevated γ-Glutamyltransferase and Erythrocyte Sedimentation Rate in Ischemic Stroke in Discordant Monozygotic Twin Study. International Journal of Stroke. 10 (4), pp. E32-E33. https://doi.org/10.1111/ijs.12440

Acetylcholine-induced coronary spasm in patients with unobstructed coronary arteries is associated with elevated concentrations of soluble CD40 ligand and high-sensitivity C-reactive protein

Journal article

Ong, P., Carro, A., Athanasiadis, A., Borgulya, G., Schäufele, T., Ratge, D., Gaze, D.C., Sechtem, U. and Kaski, J. 2015. Acetylcholine-induced coronary spasm in patients with unobstructed coronary arteries is associated with elevated concentrations of soluble CD40 ligand and high-sensitivity C-reactive protein. Coronary Artery Disease. 26 (2), pp. 126-132. https://doi.org/10.1097/mca.0000000000000181

Effects of seated and standing cold water immersion on recovery from repeated sprinting

Journal article

Leeder, J., van Someren, K., Bell, P., Spence, J., Jewell, A., Gaze, D.C. and Howatson, G. 2015. Effects of seated and standing cold water immersion on recovery from repeated sprinting. Journal of Sports Sciences. 33 (15), pp. 1544-1552. https://doi.org/10.1080/02640414.2014.996914

The association between fibrinogen reactivity to mental stress and high-sensitivity cardiac troponin T in healthy adults

Journal article

Lazzarino, A., Hamer, M., Gaze, D.C., Collinson, P., Rumley, A., Lowe, G. and Steptoe, A. 2015. The association between fibrinogen reactivity to mental stress and high-sensitivity cardiac troponin T in healthy adults. Psychoneuroendocrinology. 59, pp. 37-48. https://doi.org/10.1016/j.psyneuen.2015.05.002

The mediation of coronary calcification in the association between risk scores and cardiac troponin T elevation in healthy adults: Is atherosclerosis a good prognostic precursor of coronary disease?

Journal article

Lazzarino, A., Hamer, M., Carvalho, L., Gaze, D.C., Collinson, P. and Steptoe, A. 2015. The mediation of coronary calcification in the association between risk scores and cardiac troponin T elevation in healthy adults: Is atherosclerosis a good prognostic precursor of coronary disease? Preventive Medicine. 77, pp. 150-154. https://doi.org/10.1016/j.ypmed.2015.05.025

Serial Changes in High-Sensitivity Cardiac Troponin, N-terminal Pro-B-Type Natriuretic Peptide, and Heart Fatty Acid Binding Protein during Exercise Echocardiography in Patients with Suspected Angina Pectoris and Normal Resting Left Ventricular Function

Journal article

de Silva, R., Tsujioka, H., Gaze, D.C., Banya, W., Shah, B., Zoppelaro, G., Hersey, J., Gonzalez, A., Collins, P., Collinson, P., Senior, R. and Fox, K. 2015. Serial Changes in High-Sensitivity Cardiac Troponin, N-terminal Pro-B-Type Natriuretic Peptide, and Heart Fatty Acid Binding Protein during Exercise Echocardiography in Patients with Suspected Angina Pectoris and Normal Resting Left Ventricular Function. Clinical Chemistry. 61 (3), pp. 554-556. https://doi.org/10.1373/clinchem.2014.228536

The clinical and diagnostic performance characteristics of the high sensitivity Abbott cardiac troponin I assay

Journal article

Collinson, P., Gaze, D.C. and Goodacre, S. 2015. The clinical and diagnostic performance characteristics of the high sensitivity Abbott cardiac troponin I assay. Clinical Biochemistry. 48 (4-5), pp. 275-281. https://doi.org/10.1016/j.clinbiochem.2014.12.017


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