Life Sciences

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HeadProf Alistair Mathie
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Widespread exploitation of the honeybee by early Neolithic farmers

Journal article

Roffet-Salque, M., Regert, M., Evershed, R.P., Outram, A.K., Cramp, L.J., Decavallas, O., Dunne, J., Gerbault, P., Mileto, S., Mirabaud, S., Paakkonen, M., Smyth, J., Soberl, L., Whelton, H.L., Alday-Ruiz, A., Asplund, H., Bartkowiak, M., Bayer-Niemeier, E., Belhouchet, L., Bernardini, F., Budja, M., Cooney, G., Cubas, M., Danaher, E.M., Diniz, M., Domboroczki, L., Fabbri, C., Gonzalez-Urquijo, J.E., Guilaine, J., Hachi, S., Hartwell, B.N., Hofmann, D., Hohle, I., Ibanez, J.J., Karul, N., Kherbouche, F., Kiely, J., Kotsakis, K., Lueth, F., Mallory, J.P., Manen, C., Marciniak, A., Maurice-Chabard, B., Mc Gonigle, M.A., Mulazzani, S., Ozdogan, M., Peric, O.S., Peric, S.R., Petrasch, J., Petrequin, A.M., Petrequin, P., Poensgen, U., Pollard, C.J., Poplin, F., Radi, G., Stadler, P., Stauble, H., Tasic, N., Urem-Kotsou, D., Vukovic, J.B., Walsh, F., Whittle, A., Wolfram, S., Zapata-Pena, L. and Zoughlami, J. 2015. Widespread exploitation of the honeybee by early Neolithic farmers. Nature. 527 (7577), pp. 226-230. https://doi.org/10.1038/nature15757

Human evolutionary genetics

Book chapter

Gerbault, P. and Thomas, M.G. 2015. Human evolutionary genetics. in: International encyclopedia of the social & behavioral sciences (second edition) Elsevier. pp. 289-296

Barriers to working with people affected by cancer: Preliminary qualitative data from a mixed methods exploration of practitioner perspectives in nutritional therapy

Article

Granger, C.A., Pilkington, K., Draper, A. and Polley, M.J. 2015. Barriers to working with people affected by cancer: Preliminary qualitative data from a mixed methods exploration of practitioner perspectives in nutritional therapy. European Journal of Integrative Medicine. 7 (6), p. 681. https://doi.org/10.1016/j.eujim.2015.07.009

The role of acute ambient hypoxia in the regulation of myostatin

PhD thesis

Elliott, B. 2015. The role of acute ambient hypoxia in the regulation of myostatin. PhD thesis University of Westminster Biomedical Sciences https://doi.org/10.34737/9ww8v

Curriculum and beyond: Mathematics support for first year life science students

Conference paper

Bailey, I., Ferrier, C. and Smith, C.L. 2015. Curriculum and beyond: Mathematics support for first year life science students. CETL-MSOR Conference 2015. University of Greenwich 08 Sep 2015 The Sigma Network.

The effect of a selective CXCR2 antagonist (AZD5069) on human blood neutrophil count and innate immune functions.

Journal article

Jurcevic, S., Humfrey, C., Uddin, M., Warrington, S., Larsson, B. and Keen, C. 2015. The effect of a selective CXCR2 antagonist (AZD5069) on human blood neutrophil count and innate immune functions. Br J Clin Pharmacol. . 80 (6), pp. 1324-36. https://doi.org/10.1111/bcp.12724

The effect of melanocortin peptides on Interleukin 1-beta induced chondrocyte cell death and inflammation

Conference poster

Can, V.C., Locke, I.C. and Getting, S.J. 2015. The effect of melanocortin peptides on Interleukin 1-beta induced chondrocyte cell death and inflammation. Physiology 2015 . Cardiff, UK. 08 Jul 2015

Urocortin – From Parkinson’s disease to the skeleton

Journal article

Lawrence, K.M., Jackson, T.R, Jamieson, D., Stevens, A., Owens, G., Sayan, B.S, Locke, I.C. and Townsend, P.A. 2015. Urocortin – From Parkinson’s disease to the skeleton. International Journal of Biochemistry & Cell Biology. 30, pp. 130-138. https://doi.org/10.1016/j.biocel.2014.12.005

Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytes.

Journal article

di Gesso, J.L., Kerr, J.S., Zhang, Q., Raheem, S., Yalamanchili, S.K., O’Hagan, D., Kay, C.D. and O'Connell, M.A. 2015. Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytes. Molecular Nutrition & Food Research. 59 (6), pp. 1143-1154. https://doi.org/10.1002/mnfr.201400799

Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells

Journal article

Amin, H.P., Czank, C., Raheem, S., Zhang, Q., Botting, N.P., Cassidy, A. and Kay, C.D. 2015. Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells. Molecular Nutrition & Food Research. 59 (6), pp. 1095-1106. https://doi.org/10.1002/mnfr.201400803

Prostate cancer cells stimulated by calcium-mediated activation of protein kinase C undergo a refractory period before re-releasing calcium-bearing microvesicles

Article

Lange, S., Stratton, D., Moore, C., Inal, J., Zheng, L. and Li, Z. 2015. Prostate cancer cells stimulated by calcium-mediated activation of protein kinase C undergo a refractory period before re-releasing calcium-bearing microvesicles. Biochemical and Biophysical Research Communications. 460 (3), pp. 511-517. https://doi.org/10.1016/j.bbrc.2015.03.061

Microvesicles released constitutively from prostate cancer cells differ biochemically and functionally to stimulated microvesicles released through sublytic C5b-9

Article

Lange, S., Stratton, D., Moore, C., Antwi-Baffour, S. and Inal, J. 2015. Microvesicles released constitutively from prostate cancer cells differ biochemically and functionally to stimulated microvesicles released through sublytic C5b-9. Biochemical and Biophysical Research Communications. 460 (3), p. 589–595. https://doi.org/10.1016/j.bbrc.2015.03.074

Data-driven Hippocampus CA1 Modeling in the Human Brain Project

Conference poster

Romani, A., Antille, N., Mercer, A., Dynes, J.A., Falk, J., Gevaert, M., Gonzalo, J.K., Kali, S., Kanari, L., Migliore, M., Lange, S., Muller, E.B., Ramaswamy, S., Reimann, M., Riquelme, R.J.L., Rössert, C.A., Shi, Y., Telefont, M., Van Geit, W.A.H., Markram, H., Thomson, A. and W.A.H. Van Geit 2015. Data-driven Hippocampus CA1 Modeling in the Human Brain Project. Neuroscience 2015. Chicago 17 Oct 2015 Society for Neuroscience.

Wearable technology in academia: the use of Google Glass in the life sciences

Article

Elliott, B. and Sukan, A. 2015. Wearable technology in academia: the use of Google Glass in the life sciences. Compass: Journal of Learning & Teaching . 6 (10).

Digestive system

Book chapter

Warford, A. and Madgwick, A. 2015. Digestive system. in: Orchard, G. and Nation, B. (ed.) Cell Structure and Function Oxford UK Oxford University Press. pp. 220-245

The effect of melanocortin peptides on Interleukin 1-beta induced chondrocyte cell death and inflammation

Conference poster

Can, V.C., Locke, I.C. and Getting, S.J. 2015. The effect of melanocortin peptides on Interleukin 1-beta induced chondrocyte cell death and inflammation. Physiology 2015. Cardiff Jun 2015

A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy

Journal article

Kholia, S., Jorfi, S., Thompson, P.R., Causey, C.P., Nicholas, A.P., Inal, J. and Lange, S. 2015. A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy. Journal of Extracellular Vesicles. 4 (1) 26192. https://doi.org/10.3402/jev.v4.26192

Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo

Journal article

Jorfi, S., Ansa-Addo, E.A., Kholia, S., Stratton, D., Valley, S., Lange, S. and Inal, J. 2015. Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo. Scientific Reports. 5 (13006) 13006. https://doi.org/10.1038/srep13006

Correlation between the expression of CD32 and CD180 receptors on CLL cells and MEC1 cell line

Article

Tsertsvadze, T., Mitskevich, N., Ghirdaladze, D. and Porakishvili, N. 2015. Correlation between the expression of CD32 and CD180 receptors on CLL cells and MEC1 cell line. Georgian Medical News. 3 (240), pp. 56-59.

Rewiring of sIgM-mediated intracellular signaling through theCD180 Toll-like receptor

Journal article

Porakishvili, N., Vispute, K., Rajakaruna, N., Kulikova, N., Tsertsvadze, T., Nathwani, A., Damle, R.N., Clark, E.A., Rai, K.R., Chiorazzi, N. and Lydyard, P.M. 2015. Rewiring of sIgM-mediated intracellular signaling through theCD180 Toll-like receptor. Molecular Medicine. 21, pp. 46-57. https://doi.org/10.2119/molmed.2014.00265

What works for Nutrition? Stories of success from Vietnam, Uganda and Kenya

Technical report

RESULTS, U.K., Concern Worldwide, University of Westminster and Keith, R. 2015. What works for Nutrition? Stories of success from Vietnam, Uganda and Kenya. London, UK Results UK.

Gag-Protease Sequence Evolution Following Protease Inhibitor Monotherapy Treatment Failure in HIV-1 Viruses Circulating in East Africa.

Article

Sutherland, K.A., Goodall, R.L., McCormick, A.L., Kapaata, A., Lyagoba, F., Kaleebu, P., Thiltgen, G., Gilks, C.F., Spyer, M., Kityo, C., Pillay, D., Dunn, D. and Gupta, R.K. 2015. Gag-Protease Sequence Evolution Following Protease Inhibitor Monotherapy Treatment Failure in HIV-1 Viruses Circulating in East Africa. AIDS Research and Human Retroviruses. 31 (10), pp. 1032-1037. https://doi.org/10.1089/aid.2015.0138

Evidence for Reduced Drug Susceptibility without Emergence of Major Protease Mutations following Protease Inhibitor Monotherapy Failure in the SARA Trial

Journal article

Sutherland, K.A., Parry, C.M., McCormick, A.L., Kapaata, A., Lyagoba, F., Kaleebu, P., Gilks, C.F., Goodall, R., Spyer, M., Kityo, C., Pillay, D., Gupta, R.K. and DART Virology Group 2015. Evidence for Reduced Drug Susceptibility without Emergence of Major Protease Mutations following Protease Inhibitor Monotherapy Failure in the SARA Trial. PLoS ONE. 10 (9) e0137834. https://doi.org/10.1371/journal.pone.0137834

IL28B genotype predicts response to chronic hepatitis C triple therapy with telaprevir or boceprevir in treatment naïve and treatment-experienced patients other than prior partial- and null-responders

Article

Calisti, G., Tavares, A., Macartney, M.J., McCormick, A.L., Labbett, W., Jacobs, M., Dusheiko, G., Rosenberg, W.M. and Haque, T. 2015. IL28B genotype predicts response to chronic hepatitis C triple therapy with telaprevir or boceprevir in treatment naïve and treatment-experienced patients other than prior partial- and null-responders. SpringerPlus. 4 (1). https://doi.org/10.1186/s40064-015-1137-x

Evaluation of sequencing of HCV core/E1, NS5A and NS5B as a genotype predictive tool in comparison with commercial assays targeting 5′UTR

Journal article

McCormick, A.L., Macartney, M.J., Abdi-Abshir, I., Labbett, W., Smith, C., Irish, D., Webster, D.P. and Haque, T. 2015. Evaluation of sequencing of HCV core/E1, NS5A and NS5B as a genotype predictive tool in comparison with commercial assays targeting 5′UTR. Journal of Clinical Virology. 66 (May), pp. 56-59. https://doi.org/10.1016/j.jcv.2015.03.006

Ultra-deep sequencing provides insights into the virology of hepatitis C super-infections in a case of three sequential infections with different genotypes

Journal article

Chung, E., Ferns, R.B., He, M., Rigatti, R., Grant, P., McCormick, A.L., Bhagani, S., Webster, D.P., Nastouli, E. and Waters, L.J. 2015. Ultra-deep sequencing provides insights into the virology of hepatitis C super-infections in a case of three sequential infections with different genotypes. Journal of Clinical Virology. 70 (Sept), pp. 63-66. https://doi.org/10.1016/j.jcv.2015.06.105

Language impairment in a case of a complex chromosomal rearrangement with a breakpoint downstream of FOXP2

Journal article

Moralli, D., Nudel, R., Chan, M.T.M., Green, C.M., Volpi, E., Benítez-Burraco, A., Newbury, D.F. and García-Bellido, P. 2015. Language impairment in a case of a complex chromosomal rearrangement with a breakpoint downstream of FOXP2 . Molecular Cytogenetics. 8 36. https://doi.org/10.1186/s13039-015-0148-1

Evidence for targeting of CD38 mRNA by the post-transcriptional regulator protein ZFP36L1

Conference poster

Murphy, J.J. 2015. Evidence for targeting of CD38 mRNA by the post-transcriptional regulator protein ZFP36L1. 4th European Congress of Immunology. Vienna 08 Sep 2015

The Notch target Hes1, is a STAT5 target gene with implications in cancer

Conference poster

Rani, A., Greenlaw, R., Galustian, C. and Murphy, J.J. 2015. The Notch target Hes1, is a STAT5 target gene with implications in cancer. 2015 Meeting of the ICIS in Bamberg, Germany, October 11th -14th. Bamberg, Germany Oct 2015 https://doi.org/10.1016/j.cyto.2015.08.214

Acute hypoxia reduces plasma myostatin independent of hypoxic dose

Conference poster

Elliott, B., Simonson, T.S., Getting, S.J., Renshaw, D., Wagner Peter, D. and MacKenzie, R. 2015. Acute hypoxia reduces plasma myostatin independent of hypoxic dose. 8th International Conference on Cachexia, Sarcopenia and Muscle Wasting. Paris 04 - 06 Dec 2015 The Society on Sarcopenia, Cachexia and Wasting Disorders.

Application of RT-Bst to enhance detection of pathogenic viruses of the respiratory tract

Article

Kabir, M.S., Clements, M.O., Atkins, M. and Kimmitt, P.T. 2015. Application of RT-Bst to enhance detection of pathogenic viruses of the respiratory tract. British Journal of Biomedical Science. 72 (3), pp. 128-134.

Comparison of virus dispersal and aerosolization by different hand-drying devices

Conference paper

Kimmitt, P.T. and Redway, K. 2015. Comparison of virus dispersal and aerosolization by different hand-drying devices. European Public Health Conference. Milan 14 Oct 2015

Physical Education or Playtime: which is more effective at promoting physical activity in primary school children?

Article

Wood, C. and Hall, K. 2015. Physical Education or Playtime: which is more effective at promoting physical activity in primary school children? BMC Research Notes. 8 (12). https://doi.org/10.1186/s13104-015-0979-1

The Workplace Simulation Project

Conference poster

Ferrier, C. 2015. The Workplace Simulation Project. IBMS Congress 2015. ICC Birmingham 28 Sep 2015

Body fat MRS

Article

Thomas, E.L. and Bell, J.D. 2015. Body fat MRS. eMagRes. 4 (3), pp. 663-672. https://doi.org/10.1002/9780470034590.emrstm1478

A case-control study of the health and wellbeing benefits of allotment gardening

Article

Wood, C., Pretty, J. and Griffin, M. 2015. A case-control study of the health and wellbeing benefits of allotment gardening. Journal of Public Health. 38 (3), pp. e336-e344. https://doi.org/10.1093/pubmed/fdv146

A randomized controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes.

Article

Guess, N.D., Dornhorst, A., Oliver, N., Bell, J.D., Thomas, E.L. and Frost, G.S. 2015. A randomized controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes. Nutrition & Metabolism. 12 (36). https://doi.org/10.1186/s12986-015-0033-2

The Breast Cancer Cookbook

Book

Keshtgar, M., Robertson, C.E. and Dwek, M. Keshtgar, M. (ed.) 2015. The Breast Cancer Cookbook. London Quadrille.

Validation of a fast method for quantification of intra-abdominal and subcutaneous adipose tissue for large-scale human studies

Article

Borga, M., Thomas, E.L., Romu, T., Rosander, J., Fitzpatrick, J., Leinhard, O.D., Bell, J.D. and Borger Magnus 2015. Validation of a fast method for quantification of intra-abdominal and subcutaneous adipose tissue for large-scale human studies. NMR in Biomedicine. 28 (12), pp. 1747-1753. https://doi.org/10.1002/nbm.3432

Dissociation between exercise-induced reduction in liver fat and changes in hepatic and peripheral glucose homeostasis in obese patients with Non-Alcoholic Fatty Liver Disease.

Journal article

Cuthbertson, D.J., Shojaee-Moradie, F., Sprung, V.S., Jones, H., Pugh, C.J., Richardson, P., Kemp, G.J., Barrett, M., Jackson, N.C., Thomas, E.L., Bell, J.D. and Umpleby, A.M. 2015. Dissociation between exercise-induced reduction in liver fat and changes in hepatic and peripheral glucose homeostasis in obese patients with Non-Alcoholic Fatty Liver Disease. Clinical Science. 130 (2), pp. 93-104. https://doi.org/10.1042/CS20150447


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