Life Sciences

Bell, P.G., Gaze, D.C., Davison, G.W., George, T.W., Scotter, M.J. and Howatson, G. 2014. Montmorency tart cherry (Prunus cerasus L.) concentrate lowers uric acid, independent of plasma cyanidin-3-O-glucosiderutinoside. Journal of Functional Foods. 11, pp. 82-90. https://doi.org/10.1016/j.jff.2014.09.004

Zhou, X.-M., Entwistle, A., Zhang, H., Jackson, A.P., Mason, T.O., Shimanovich, U., Knowles, T.P.J., Smith, A.T., Sawyer, E.B. and Perrett, S. 2014. Self-assembly of amyloid fibrils that display active enzymes. ChemCatChem. 6 (7), pp. 1961-1968. https://doi.org/10.1002/cctc.201402125

Hu, C., Chan, S.I., Sawyer, E.B., Yu, Y. and Wang, J. 2014. Metalloprotein design using genetic code expansion. Chemical Society Reviews. 43, pp. 6498-6510. https://doi.org/10.1039/c4cs00018h

Patel, H. and Kukol, A 2014. Influenza A nucleoprotein binding sites for antivirals: current research and future potential. Future Virology. 9, pp. 625-627. https://doi.org/10.2217/fvl.14.45

Li, J., Kent, D.G., Godfrey, A.L., Manning, H., Nangalia, J., Aziz, A., Chen, E., Saeb-Parsy, K., Find, J., Sneade, R., Hamilton, T.L., Pask, D.C., Silber, Y., Zhao, X., Ghevaert, C., Liu, P. and Green, A.R. 2014. JAK2V617F homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease. Blood. 123, pp. 3139-3151. https://doi.org/10.1182/blood-2013-06-510222

Chen, E., Ahn, J.S., Massie, C.E., Clynes, D., Godfrey, A.L., Li, J., Park, H.J., Nangalia, J., Silber, Y., Mullally, A., Gibbons, R.J. and Green, A.R. 2014. JAK2V617F promotes replication fork stalling with disease-restricted impairment of the intra-S checkpoint response. Proceedings of the National Academy of Sciences of the United States of America. 111, pp. 15190-15195. https://doi.org/10.1073/pnas.1401873111

Chen, E. and Mullally, A. 2014. How does JAK2V617F contribute to pathogenesis of myeloproliferative neoplasms? (Review). Hematology American Society of Hematology Education Program. 2014, pp. 268-276. https://doi.org/10.1182/asheducation-2014.1.268

Phillips, G., Bottomley, C., Schmidt, E., Tobi, P., Lais, S., Yu, G., Lynch, R., Lock, K., Draper, A., Moore, D., Clow, A., Petticrew, M., Hayes, R. and Renton, A. 2014. Well London Phase-1: results among adults of a cluster-randomised trial of a community engagement approach to improving health behaviours and mental well-being in deprived inner-city neighbourhoods . Journal of Epidemiology & Community Health. 68 (7), pp. 606-614. https://doi.org/10.1136/jech-2013-202505

Taneja, A., Gaze, D.C., Coats, A., Dumitrascu, D., Spinarova, L., Collinson, P., Roughton, M. and Flather, M. 2014. Effects of nebivolol on biomarkers in elderly patients with heart failure. International Journal of Cardiology. 175 (2), pp. 253-260. https://doi.org/10.1016/j.ijcard.2014.05.018

Leeder, J., van Someren, K., Gaze, D.C., Jewell, A., Deshmukh, N., Shah, I., Barker, J. and Howatson, G. 2014. Recovery and Adaptation From Repeated Intermittent-Sprint Exercise. International Journal of Sports Physiology and Performance. 9 (3), pp. 489-946. https://doi.org/10.1123/ijspp.2012-0316

Gaze, D.C. and Collinson, P. 2014. Cardiac troponin I but not cardiac troponin T adheres to polysulfone dialyser membranes in an in vitro haemodialysis model: explanation for lower serum cTnI concentrations following dialysis. Open Heart. 1 (1), p. e000108 e000108. https://doi.org/10.1136/openhrt-2014-000108

Gaze, D.C., Prante, C., Dreier, J., Knabbe, C., Collet, C., Launay, J., Franekova, J., Jabor, A., Lennartz, L., Shih, J., del Rey, J., Zaninotto, M., Plebani, M. and Collinson, P. 2014. Analytical evaluation of the automated galectin-3 assay on the Abbott ARCHITECT immunoassay instruments. Clinical Chemistry and Laboratory Medicine . 52 (6), pp. 919-926. https://doi.org/10.1515/cclm-2013-0942

Gaze, D.C. 2014. Research Highlights: Run for your life: reduction in inflammatory mediators following cardiac rehabilitation. Biomarkers in Medicine. 8 (2), pp. 233-237. https://doi.org/10.2217/bmm.13.148

Collinson, P., Gaze, D.C. and Goodacre, S. 2014. Comparison of contemporary troponin assays with the novel biomarkers, heart fatty acid binding protein and copeptin, for the early confirmation or exclusion of myocardial infarction in patients presenting to the emergency department with chest pain. Heart. 100 (2), pp. 140-145. https://doi.org/10.1136/heartjnl-2013-304716

MacKenzie, R. and Elliott, B. 2014. Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 7, pp. 55-67. https://doi.org/10.2147/DMSO.S48260

Newell, M., Wallis, G.A. and Galloway, S.D.R. 2014. Impact of carbohydrate nutrition on exercise metabolism and performance. AgroFOOD Industry Hi-Tech. 25 (2), pp. 32-36.

Youssef, G., Gillett, C., Agbaje, O., Crompton, T. and Montano Hernandez, X. 2014. Phosphorylation of NTRK1 at Y674/Y675 induced by TP53-dependent repression of PTPN6 expression: a potential novel prognostic marker for breast cancer. Modern Pathology. 27, pp. 361-374 23948750. https://doi.org/10.1038/modpathol.2013.129

Preston, L.J. and Dartnell, L. 2014. Planetary habitability: lessons learned from terrestrial analogues. International Journal of Astrobiology. 13 (1). https://doi.org/10.1017/S1473550413000396

Dartnell, L. and Patel, M.R. 2014. Degradation of microbial fluorescence biosignatures by solar ultraviolet radiation on Mars. International Journal of Astrobiology. 13 (2), pp. 112-123. https://doi.org/10.1017/S1473550413000335

Herschy, B., Whicher, A., Camprubi, E., Watson, C., Dartnell, L., Ward, J., Evans, J.R.G. and Lane, N. 2014. An Origin-of-Life Reactor to Simulate Alkaline Hydrothermal Vents. Journal of Molecular Evolution. 79 (5-6), pp. 213-227. https://doi.org/10.1007/s00239-014-9658-4

Makela, P., Gawned, S and Jones, F 2014. Starting early: integration of self-management support into an acute stroke service. BMJ Open Quality. 3 (1) u202037.w1759. https://doi.org/10.1136/bmjquality.u202037.w1759

Zupancic, S., Kocbek, P., Kristl, J., Zariwala, M., Renshaw, D., Gul, M.O., Elsaid, Z., Taylor, K.M.G. and Somavarapu, S. 2014. Formulation and characterization of curcumin loaded DQAsomes for pulmonary delivery. 10th International Conference and Workshop on Biological Barriers. Saarbrücken 16 - 21 Feb 2014

Zariwala, M., Kosicka, A., MacKenzie, R. and Renshaw, D. 2014. Serum ferritin levels are correlated with total adiposity, but not BMI in obese males. Society for Endocrinology BES 2014. Liverpool, UK 24 - 27 Mar 2014 BioScientifica Ltd.. https://doi.org/10.1530/endoabs.34.P255

Zariwala, M. and Farnaud, S. 2014. A human cell model of Parkinson’s disease confirms iron accumulation in dopaminergic neurons following 6-OHDOPA treatment. European Iron Club Annual Meeting 2014. Verona, Italy 11 - 14 Sep 2014

Zariwala, M., Bendre, H., Markiv, A., Farnaud, S., Somavarapu, S. and Renshaw, D. 2014. Fabrication and characterization of novel hydrophobically modified chitosan nanoliposomes for oral iron delivery. European Iron Club Annual Meeting 2014. Verona, Italy 11 - 14 Sep 2014

Butterworth, S., Overduin, M. and Barr, A.J. 2014. Targeting protein tyrosine phosphatase SHP2 for therapeutic intervention. Future Medicinal Chemistry. 6 (12), pp. 1423-1437. https://doi.org/10.4155/fmc.14.88

Fagan-Watson, B., Watson, T., Elliott, B., Vanner, R., Shaw, Ben and Morris, S. 2014. What range of methods is available to evaluate the implementation and impact of complex environmental policies on complex systems? A report to the Department for Environment, Food and Rural Affairs. Policy Studies Institute. Defra, London.

Derges, J., Clow, A., Lynch, R., Jain, S., Phillips, G., Petticrew, M., Renton, A. and Draper, A. 2014. ‘Well London’ and the benefits of participation: results of a qualitative study nested in a cluster randomised trial. BMJ Open. 2014 (4), p. e003596 e003596. https://doi.org/10.1136/bmjopen-2013-003596

Walker, K. and Green, J. 2014. The development of Eucalyptus as a medicine. National Institute of Medical Herbalists 150th Annual Conference. Nottingham 09 - 13 Oct 2014

Pérez Blanco, E. and Lewis, J. 2014. A comparative study of Alexandrium tamarense cyst distribution in Belfast Lough. European Journal of Phycology. 49 (2), pp. 255-263. https://doi.org/10.1080/09670262.2014.912761

Taylor, J., Kegel, J.U., Lewis, J. and Medlin, L.K. 2014. Validation of the detection of Alexandrium spp using specific RNA probes tested in a microarray format: Calibration of signal using variability of RNA content with environmental conditions. Harmful Algae. 37, pp. 17-27. https://doi.org/10.1016/j.hal.2014.05.001

Voyias, P., Antonysunil, A., Kumasaiyai, W., Kyrou, I., Vrbikova, J., Hainer, V., Fried, M., Sramkova, P., Saravanan, P., Kumar, S., McTernan, P. and Tripathi, G. 2014. Unfolded protein response in adipose tissue of obese diabetic women significantly improved 6 months post bariatric surgery, irrespective of malabsorptive or bypass operation type and correlates with plasma glucose concentration. Society for Endocrinology BES 2014. Liverpool 24 - 27 May 2017 Society for Endocrinology. https://doi.org/10.1530/endoabs.34.P269

Al-Disi, D., Al-Daghri, N., Khan, N., Alsaif, M., Alfadda, A., Sabico, S., Tripathi, G. and McTernan, P. 2014. A 3-month low fat diet leads to significant lipid profile improvement in obese T2DM Saudi subjects, without substantial weight loss, and the capacity to manage a damaging high-fat meal challenge more appropriately post intervention. Society for Endocrinology BES 2014. Liverpool 24 - 27 May 2014 Society for Endocrinology. https://doi.org/10.1530/endoabs.34.P223

Kumsaiyai, W., Al-Daghri, N., Kyrou, I., Vrbikova, J., Hainer, V., Fried, M., Sramkova, P., Barber, T., S Kumar,, Tripathi, G. and McTernan, P. 2014. Systemic triglycerides as a key determinant of TLR regulated inflammatory risk in human adipose tissue post bariatric surgical intervention and weight loss. Society for Endocrinology BES 2014. Liverpool 24 - 27 Mar 2014 Society for Endocrinology. https://doi.org/10.1530/endoabs.34.P238

Piya, M., Reddy, N., Campbell, A., Hattersley, J., Halder, L., Tripathi, G., Tahrani, A., Kumar, S., Barber, T. and McTernan, P. 2014. Meal size and frequency influences metabolic endotoxaemia and inflammatory risk but has no effect on diet induced thermogenesis in either lean or obese subjects. Society for Endocrinology BES 2014. Liverpool 24 - 27 May 2014 Society for Endocrinology. https://doi.org/10.1530/endoabs.34.P226

Antonysunil, A., Vatish, M., Lawson, A., Wood, C., Sivakumar, K., Webster, C., Anderson, N., McTernan, P., Tripathi, G. and Saravanan, P. 2014. Elevated cord leptin from low B12 mothers predicts birth weight. Society for Endocrinology BES 2014. Liverpool 24 - 27 May 2014 Society for Endocrinology. https://doi.org/10.1530/endoabs.34.P262

Voyias, P., Antonysunil, A., Kumasaiyai, W., Kyrou, I., Vrbikova, J., Hainer, V., Fried, M., Sramkova, P., Saravanan, P., Kumar, S., McTernan, P. and Tripathi, G. 2014. Bariatric surgery induced weight loss and systemic glucose regulates intracellular unfolded protein response within human adipose tissue from type 2 diabetes mellitus patients. 74th Scientific Sessions of the American Diabetes Association. San Francisco, USA 13 - 17 Jun 2014

Adaikalakoteswari, A., Finer, S., Voyias, P.D., McCarthy, M., Vatish, M., Moore, J., Smart-Halajko, M., Bawazeer, N., Al-Daghri, N.M., McTernan, P.G., Hitman, G.A., Saravanan, P. and Tripathi, G. 2014. Methyl Donor Deficiency Due to Low Vitamin B12 Impairs Insulin Signalling in Human Adipocytes by Down Regulating Akt Pathway via PTEN and TRB3. 74th Scientific Sessions of the American Diabetes Association. San Francisco, USA 13 - 17 Jun 2014

Patel, A., N Williams, N., Nwokolo, C., Tripathi, G. and Arasaradnam, R. 2014. PWE-001 Field Cancerisation Theory In Colorectal Cancer (crc): What Role Do Fibroblast Growth Factors Have? British Society of Gastroenterology Annual General Meeting. 16 - 19 Jun 2014 BMJ. https://doi.org/10.1136/gutjnl-2014-307263.261

Adaikalakoteswari, A., Finer, S., Hitman, G.A., Saravanan, P. and Tripathi, G. 2014. Vitamin B12 deficiency induces adipocyte dysfunction via enhanced cholesterol biosynthesis, unfolded protein response and associated epigenetic marks. 41st UK Adipose Tissue Discussion Group. Norwich 15 Dec 2014