A novel pressure sensing circuit for non-invasive RF/microwave blood glucose sensors is presented in this paper. RF sensors are of interest to researchers for measuring blood glucose levels non-invasively. For the measurements, the finger is a popular site that has a good amount of blood supply. When a finger is placed on top of the RF sensor, the electromagnetic fields radiating from the sensor interact with the blood in the finger and the resulting sensor response depends on the permittivity of the blood. The varying glucose level in the blood results in a permittivity change causing a shift in the sensor’s response. Therefore, by observing the sensor’s frequency response it may be possible to predict the blood glucose level. However, there are two crucial points in taking and subsequently predicting the blood glucose level. These points are; the position of the finger on the sensor and the pressure applied onto the sensor. A variation in the glucose level causes a very small frequency shift. However, finger positioning and applying inconsistent pressure have more pronounced effect on the sensor response. For this reason, it may not be possible to take a correct reading if these effects are not considered carefully. Two novel pressure sensing circuits are proposed and presented in this paper to accurately monitor the pressure applied.