Life Sciences

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HeadProf Alistair Mathie
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2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm

Journal article

Partridge, F.A., Forman, R., Willis, N.J., Bataille, C.J.R., Murphy, E.A., Brown, A.E., Heyer-Chauhan, N., Bruno Marinič, B., Sowood, D.J.C., Wynne, G.M., Else, K.J., Russell, A.J. and Sattelle, D.B. 2018. 2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm. PLoS Neglected Tropical Diseases. 12 (7) e0006487. https://doi.org/10.1371/journal.pntd.0006487

Preprint: 2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm

Other

Partridge, F.A., Forman, R., Willis, N.J., Bataille, C.J.R., Murphy, E.A., Brown, A.E., Heyer-Chauhan, N., Bruno Marinič, B., Sowood, D.J.C., Wynne, G.M., Else, K.J., Russell, A.J. and Sattelle, D.B. 2018. Preprint: 2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm. biorxiv.org. https://doi.org/10.1101/254037

An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes

Journal article

Partridge, F.A., Brown, A.E., Buckingham, S.D., Willis, N.J., Wynne, G.M., Forman, R., Else, K.J., Morrison, A.A., Matthews, J.B., Russell, A.J., Lomas, D.A. and Sattelle, D.B. 2018. An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes. International Journal for Parasitology: Drugs and Drug Resistance. 8 (1), pp. 8-21. https://doi.org/10.1016/j.ijpddr.2017.11.004

Hybridization to High-Density Filter Arrays of a Brugia malayi BAC Library with Biotinylated Oligonucleotides and PCR Products

Journal article

Foster, J.M., Kamal, I.H., Daub, J., Swan, M.C., Ingram, J.R., Ganatra, M., Ware, J., Guiliano, D.B., Aboobaker, A., Moran, L., Blaxter, M. and Slatko, B.E. 2018. Hybridization to High-Density Filter Arrays of a Brugia malayi BAC Library with Biotinylated Oligonucleotides and PCR Products. BioTechniques. 30 (6), pp. 1216-1224. https://doi.org/10.2144/01306bm06

Muscle tensions merge to cause a DNA replication crisis.

Journal article

Brayson, D., Ho, C.Y. and Shanahan, C.M. 2018. Muscle tensions merge to cause a DNA replication crisis. The Journal of Cell biology. 217 (6), pp. 1891-1893. https://doi.org/10.1083/jcb.201804041

Preprint: Accumulation of prelamin A drives inflammation in the heart with implications for treatment of inherited and acquired cardiomyopathies

Other

Daniel Brayson, Andrea Frustaci, Romina Verardo, Cristina Chimenti, Matteo Antonio Russo, Robert Hayward, Sadia Munir Ahmad, Gema Vizcay-Barrena, Andrea Protti, Peter S. Zammit, Cristobal G. dos Remedios, Elisabeth Ehler, Ajay M. Shah and Catherine M. Shanahan 2018. Preprint: Accumulation of prelamin A drives inflammation in the heart with implications for treatment of inherited and acquired cardiomyopathies. biorxiv.org. https://doi.org/10.1101/457044

NADPH Oxidase 5 Is a Pro‐Contractile Nox Isoform and a Point of Cross‐Talk for Calcium and Redox Signaling‐Implications in Vascular Function

Journal article

Augusto C. Montezano, Livia De Lucca Camargo, Patrik Persson, Francisco J. Rios, Adam P. Harvey, Aikaterini Anagnostopoulou, Roberto Palacios, Ana Caroline P. Gandara, Rheure Alves‐Lopes, Karla B. Neves, Maria Dulak‐Lis, Chet E. Holterman, Pedro Lagerblad de Oliveira, Delyth Graham, Christopher Kennedy and Rhian M. Touyz 2018. NADPH Oxidase 5 Is a Pro‐Contractile Nox Isoform and a Point of Cross‐Talk for Calcium and Redox Signaling‐Implications in Vascular Function. Journal of the American Heart Association. 7 (12) e009388. https://doi.org/10.1161/jaha.118.009388

Vascular smooth muscle contraction in hypertension

Journal article

Rhian M Touyz, Rheure Alves-Lopes, Francisco J Rios, Livia L Camargo, Aikaterini Anagnostopoulou, Anders Arner and Augusto C Montezano 2018. Vascular smooth muscle contraction in hypertension. Cardiovascular Research. 114 (4), pp. 529-539. https://doi.org/10.1093/cvr/cvy023

Prostate cancer detection using quantitative T2 and T2-weighted imaging: The effects of 5-alpha-reductase inhibitors in men on active surveillance

Journal article

Giganti, F., Gambarota, G., Moore, C.M., Robertson, N.L., Mccartan, N., Jameson, C., Bott, S.R., Winkler, M., Whitcher, B., Castro-Santamaria, R., Emberton, M., Allen, C. and Kirkham, A. 2018. Prostate cancer detection using quantitative T2 and T2-weighted imaging: The effects of 5-alpha-reductase inhibitors in men on active surveillance. Journal of Magnetic Resonance Imaging. 47 (6), pp. 1646-1653. https://doi.org/10.1002/jmri.25891

The Impact of Physical Activity intervention on university employees’ behaviour change, health and well-being

Conference item

Safi, A., Cole, M. and Walker, N. 2018. The Impact of Physical Activity intervention on university employees’ behaviour change, health and well-being. BASES Division of Physical Activity for Health Divisional Day Conference. Coventry University, UK 08 Feb 2018

Do University employees meet the physical activity guidelines’ (within or outside the workplace)?

Conference paper

Safi, A., Cole, M. and Walker, N. 2018. Do University employees meet the physical activity guidelines’ (within or outside the workplace)? Population Health and Prevention Conference by Public Health England. Leeds, UK 07 Mar 2018

How to eat right and keep well during Ramadan

Other

Al-Kateb, H., Cole, M. and Safi, A. 2018. How to eat right and keep well during Ramadan. Al Jazeera.

Researchers give tips for a healthy Ramadan

Other

Safi, A. 2018. Researchers give tips for a healthy Ramadan. The Press Reader.

Eating right and keeping well during Ramadan

Other

Al-Kateb, H., Cole, M. and Safi, A. 2018. Eating right and keeping well during Ramadan. Times of Oman.

How to stay healthy while fasting during festival

Other

Safi, A. and Badiani, Y. 2018. How to stay healthy while fasting during festival. The Independent.

Eating right and keeping well during Ramadan

Article

Al-Kateb, H., Cole, M. and Safi, A. 2018. Eating right and keeping well during Ramadan. HealthToday. HT, pp. 14-17.

Genomic variant classifier tool

Book chapter

Grau, I., Sengupta, D., Farid, D.M., Manderick, B., Nowe, A., Garcia Lorenzo, M.M., Daneels, D., Bonduelle, M., Croes, D. and Van Dooren, S. 2018. Genomic variant classifier tool. in: IntelliSys 2016: Proceedings of SAI Intelligent Systems Conference (IntelliSys) 2016 Springer.

Phenotype-loci associations in networks of patients with rare disorders: application to assist in the diagnosis of novel clinical cases

Journal article

Bueno, A., Rodríguez-López, R., Reyes-Palomares, A., Rojano, E., Corpas, M., Nevado, J., Lapunzina, P., Sánchez-Jiménez, F. and Ranea, J.A.G. 2018. Phenotype-loci associations in networks of patients with rare disorders: application to assist in the diagnosis of novel clinical cases. European Journal of Human Genetics. 26, pp. 1451-1461. https://doi.org/10.1038/s41431-018-0139-x

A FAIR guide for data providers to maximise sharing of human genomic data

Journal article

Corpas, M., Kovalevskaya, N.V., McMurray, A. and Nielsen, F.G.G. 2018. A FAIR guide for data providers to maximise sharing of human genomic data. PLOS Computational Biology. 14 (3) e1005873. https://doi.org/10.1371/journal.pcbi.1005873

Personal Genome Project UK (PGP-UK): A research and citizen science hybrid project in support of personalized medicine

Journal article

Beck, S., Berner, A.M., Bignell, G., Bond, M., Callanan, M.J., Chervova, O., Conde, L., Corpas, M., Ecker, S., Elliott, H.R., Fioramonti, S.A., Flanagan, A.M., Gaentzsch, R., Graham, D., Gribbin, D., Guerra-Assunção, J.A., Hamoudi, R., Harding, V., Harrison, P.L., Herrero, J., Hofmann, J., Jones, E., Khan, S., Kaye, J., Kerr, P., Libertini, E., Marks, L., McCormack, L., Moghul, I., Pontikos, N., Rajanayagam, S., Rana, K., Semega-Janneh, M., Smith, C.P., Strom, L., Umur, S., Webster, A.P., Williams, E.H., Wint, K. and Wood, J.N. 2018. Personal Genome Project UK (PGP-UK): A research and citizen science hybrid project in support of personalized medicine. BMC Medical Genomics. 11 108. https://doi.org/10.1186/s12920-018-0423-1

APPLaUD: Access for patients and participants to individual level uninterpreted genomic data

Journal article

Thorogood, A., Bobe, J., Prainsack, B., Middleton, A., Scott, E., Nelson, S., Corpas, M., Bonhomme, N., Rodriguez, L.L., Murtagh, M. and Kleiderman, E. 2018. APPLaUD: Access for patients and participants to individual level uninterpreted genomic data. Human Genomics. 12 7. https://doi.org/10.1186/s40246-018-0139-5

Modulation of Beta Bursts in the Subthalamic Nucleus Predicts Motor Performance

Journal article

Flavie Torrecillos, Gerd Tinkhauser, Petra Fischer, Alexander L. Green, Tipu Z. Aziz, Thomas Foltynie, Patricia Limousin, Ludvic Zrinzo, Keyoumars Ashkan, Peter Brown, Huiling Tan and Green, A. 2018. Modulation of Beta Bursts in the Subthalamic Nucleus Predicts Motor Performance. Journal of Neuroscience. 38 (41), pp. 8905-8917. https://doi.org/10.1523/jneurosci.1314-18.2018

Zebrafish Infection: From Pathogenesis to Cell Biology

Journal article

Vincenzo Torraca and Serge Mostowy 2018. Zebrafish Infection: From Pathogenesis to Cell Biology. Trends in Cell Biology. 28 (2), pp. P143-156. https://doi.org/10.1016/j.tcb.2017.10.002

Shigella-Induced Emergency Granulopoiesis Protects Zebrafish Larvae from Secondary Infection

Journal article

Willis, Alexandra R., Torraca, V., Gomes, Margarida C., Shelley, Jennifer, Mazon-Moya, Maria, Filloux, Alain, Lo Celso, Cristina and Mostowy, Serge 2018. Shigella-Induced Emergency Granulopoiesis Protects Zebrafish Larvae from Secondary Infection. mBio. 9 (3) e00933-18. https://doi.org/10.1128/mbio.00933-18

PO-018 Acquired DNA damage in adolescent obesity – a promoter and predictor of cancer?

Article

Usman, M. and Volpi, E.V. 2018. PO-018 Acquired DNA damage in adolescent obesity – a promoter and predictor of cancer? ESMO Open. 3 (Supplement 2), pp. A27-A28. https://doi.org/10.1136/esmoopen-2018-eacr25.66

Acute cardiovascular responses to resistance exercise in anabolic steroids users: A preliminary investigation / Réponses cardiovasculaires aigues à l'exercice de résistance chez les utilisateurs de stéroïdes anaboliques

Journal article

Angell, P.J., Green, D.J., Lord, R., Gaze, D.C., Whyte, G. and George, K.P. 2018. Acute cardiovascular responses to resistance exercise in anabolic steroids users: A preliminary investigation / Réponses cardiovasculaires aigues à l'exercice de résistance chez les utilisateurs de stéroïdes anaboliques. Science and Sports. https://doi.org/10.1016/j.scispo.2018.05.003

Appraising the Effects of Physical Activity Interventions on Risk Factors of Cardiovascular Diseases and Obesity: A Systematic Review

Journal article

Sum, K. and Tewfik, I. 2018. Appraising the Effects of Physical Activity Interventions on Risk Factors of Cardiovascular Diseases and Obesity: A Systematic Review. International Journal of Food, Nutrition and Public Health. 10 (1), pp. 40-77. https://doi.org/10.47556/J.IJFNPH.10.1.2018.4

Growing from a Seed

Journal article

Sum, K. 2018. Growing from a Seed. Student Engagement in Higher Education Journal. 2 (1), pp. 7-11.

Translational regulation in mycobacteria and its implications for pathogenicity

Journal article

Sawyer, E.B., Grabowska, A. and Cortes, T. 2018. Translational regulation in mycobacteria and its implications for pathogenicity. Nucleic Acids Research. 46 (14), pp. 6950-6961. https://doi.org/10.1093/nar/gky574

Multinodular and vacuolating neuronal tumors in epilepsy: dysplasia or neoplasia?

Journal article

Thom, M., Liu, J., Bongaarts, A., Reinten, R., Paradiso, B., Jäger, H., Reeves, C., Somani, A., An, S., Marsdon, D., McEvoy, A., Miserocchi, A., Thorne, L., Newman, F., Bucur, S., Honavar, M., Jacques, T. and Aronica, E. 2018. Multinodular and vacuolating neuronal tumors in epilepsy: dysplasia or neoplasia? Brain Pathology. 28 (2), pp. 155-171. https://doi.org/10.1111/bpa.12555

Characterising subtypes of hippocampal sclerosis and reorganization: correlation with pre and postoperative memory deficit

Journal article

Prada Jardim, A., Liu, J., Baber, J., Michalak, Z., Reeves, C., Ellis, M., Novy, J., de Tisi, J., McEvoy, A., Miserocchi, A., Targas Yacubian, E., Sisodiya, S., Thompson, P. and Thom, M. 2018. Characterising subtypes of hippocampal sclerosis and reorganization: correlation with pre and postoperative memory deficit. Brain Pathology. 28 (2), pp. 143-154. https://doi.org/10.1111/BPA.12514

The Blood-Brain Barrier in Psychosis

Journal article

Pollak, T.A., Drndarski, S., Stone, M.J., David, A.S., McGuire, P. and Abbott, N.J. 2018. The Blood-Brain Barrier in Psychosis. The Lancet Psychiatry. 5 (1), pp. 79-92. https://doi.org/10.1016/S2215-0366(17)30293-6

Defining the requirements for the pathogenic interaction between mutant calreticulin and MPL in MPN

Journal article

Elf, S., Abdelfattah, N.S., Baral, A.J., Beeson, D., Rivera, J.F., Ko, A., Florescu, N., Birrane, G., Chen, E. and Mullally, A. 2018. Defining the requirements for the pathogenic interaction between mutant calreticulin and MPL in MPN. Blood. 131 (7), pp. 782-786. https://doi.org/10.1182/blood-2017-08-800896

Human papillomavirus Genotype Distribution and Co-infection with Sexually Transmitted Pathogens in Reproductive age Women in Urban Gambia

PhD thesis

Bah Camara, H. 2018. Human papillomavirus Genotype Distribution and Co-infection with Sexually Transmitted Pathogens in Reproductive age Women in Urban Gambia. PhD thesis University of Westminster Faculty of Science and Technology https://doi.org/10.34737/qx759

Serological evidence of myocardial injury with exercise

Book chapter

Shave, R. and Gaze, D.C. 2018. Serological evidence of myocardial injury with exercise. in: Thompson, P.D. and Fernandez, A.B. (ed.) Thompson Exercise and Sports Cardiology volume 3: Exercise Risks, Cardiac Arrhythmias and Unusual Problems in Athletes World Scientific Publishing.

Pathophysiology: Altered Physiological States

Book

Gaze, D.C. (ed.) 2018. Pathophysiology: Altered Physiological States. Croatia InTech Publishing.

Introductory Chapter: Congenital Heart Disease

Book chapter

Gaze, D.C. 2018. Introductory Chapter: Congenital Heart Disease. in: Gaze, D.C. (ed.) Congenital Heart Disease Croatia InTech Publishing. pp. 1-4

Congenital Heart Disease

Book

Gaze, D.C. (ed.) 2018. Congenital Heart Disease. Croatia InTech Publishing.

The ventrolateral medulla and medullary raphe in sudden unexpected death in epilepsy

Journal article

Patodia, S., Somani, A., O’Hare, M., Venkateswaran, R., Liu, J., Michalak, Z., Ellis, M., Scheffer, I., Diehl, B., Sisodiya, S. and Thom, M. 2018. The ventrolateral medulla and medullary raphe in sudden unexpected death in epilepsy. Brain. 141 (6), pp. 1719-1733. https://doi.org/10.1093/brain/awy078

Ultrasensitive quantification of cardiac troponin I by a Single Molecule Counting method: analytical validation and biological features

Journal article

Garcia-Osuna, A., Gaze D.C., Grau-Agramunt, M., Morris, T., Telha, C., Bartolome, A., Bishop, J., Monsalve, L., Livingston, R., Estis, J., Nolan, N., Sandlund, J. and Ordonez-Llanos, J. 2018. Ultrasensitive quantification of cardiac troponin I by a Single Molecule Counting method: analytical validation and biological features. Clinica Chimica Acta. 486, pp. 224-231. https://doi.org/10.1016/j.cca.2018.08.015


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