Life Sciences

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HeadProf Alistair Mathie
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Improving Physiological Relevance of Cell Culture: The Possibilities, Considerations and Future Directions of the Ex Vivo Co-Culture Model

Journal article

Allen, Sophie L., Elliott, Bradley T., Carson, Brian P. and Breen, Leigh 2023. Improving Physiological Relevance of Cell Culture: The Possibilities, Considerations and Future Directions of the Ex Vivo Co-Culture Model. American Journal of Physiology: Cell Physiology. 324 (2), pp. C420-C427. https://doi.org/10.1152/ajpcell.00473.2022

Artifact-Free Fat-Water Separation in Dixon MRI using Deep Learning

Journal article

Basty, N., Thanaj, M., Cule, M., Sorokin, E., Liu, Y., Thomas, E.L., Bell, J.D. and Whitcher, B. 2023. Artifact-Free Fat-Water Separation in Dixon MRI using Deep Learning. Journal of Big Data. 10 4. https://doi.org/10.1186/s40537-022-00677-1

Enhanced production of biobased, biodegradable, Poly(3-hydroxybutyrate) using an unexplored marine bacterium Pseudohalocynthiibacter aestuariivivens, isolated from highly polluted coastal environment.

Journal article

Esposito, Fortunato Palma, Vecchiato, Vittoria, Buonocore, Carmine, Tedesco, Pietro, Noble, Brendon, Basnett, Pooja and de Pascale, Donatella 2023. Enhanced production of biobased, biodegradable, Poly(3-hydroxybutyrate) using an unexplored marine bacterium Pseudohalocynthiibacter aestuariivivens, isolated from highly polluted coastal environment. Bioresource Technology. 368, p. 128287. https://doi.org/10.1016/j.biortech.2022.128287

Special Issue "The Exposome in Immune Evolution, Health and Disease"

Edited issue

Lange, S. 2023. Special Issue "The Exposome in Immune Evolution, Health and Disease". Biology.

An exploration into the impact that shift work has on the nutritional behaviours of UK police officers

Journal article

Allen, K., Safi, A. and Deb, S. 2023. An exploration into the impact that shift work has on the nutritional behaviours of UK police officers. British Journal of Nutrition. 130 (2), pp. 284-293. https://doi.org/10.1017/s0007114522002999

Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models.

Journal article

Allesøe, Rosa Lundbye, Lundgaard, A., Hernández Medina, R., Aguayo-Orozco, Alejandro, Johansen, J., Nissen, Jakob Nybo, Brorsson, Caroline, Mazzoni, Gianluca, Niu, L., Biel, J., Brasas, Valentas, Webel, Henry, Benros, M., Pedersen, A., Chmura, Piotr Jaroslaw, Jacobsen, U., Mari, Andrea, Koivula, R., Mahajan, Anubha, Vinuela, A., Tajes, Juan Fernandez, Sharma, Sapna, Haid, M., Hong, M., Musholt, Petra B, De Masi, Federico, Vogt, Josef, Pedersen, Helle Krogh, Gudmundsdottir, Valborg, Jones, Angus, Kennedy, G., Bell, Jimmy, Thomas, E.L., Frost, G., Thomsen, Henrik, Hansen, Elizaveta, Hansen, T., Vestergaard, Henrik, Muilwijk, Mirthe, Blom, Marieke T, 't Hart, Leen M, Pattou, Francois, Raverdy, Violeta, Brage, Soren, Kokkola, Tarja, Heggie, Alison, McEvoy, Donna, Mourby, Miranda, Kaye, J., Hattersley, A., McDonald, Timothy, Ridderstråle, M., Walker, Mark, Forgie, Ian, Giordano, Giuseppe N, Pavo, Imre, Ruetten, Hartmut, Pedersen, O., Hansen, T., Dermitzakis, Emmanouil, Franks, Paul W, Schwenk, J., Adamski, Jerzy, McCarthy, Mark I, Pearson, Ewan, Banasik, Karina, Rasmussen, S., Brunak, S. and IMI DIRECT Consortium 2023. Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models. Nature Biotechnology. 41, pp. 399-408. https://doi.org/10.1038/s41587-022-01520-x

Preprint: Liver Shape Analysis using Statistical Parametric Maps at Population Scale

Other

Thanaj, M., Basty, N., Cule, M., Sorokin, E.P., Whitcher, B., Bell, J.D. and Thomas, E.L. 2023. Preprint: Liver Shape Analysis using Statistical Parametric Maps at Population Scale. medRxiv. https://doi.org/10.1101/2022.08.18.22278951

Septins promote caspase activity and coordinate mitochondrial apoptosis

Journal article

Hoan Van Ngo, Stevens Robertin, Dominik Brokatzky, Magdalena K. Bielecka, Damián Lobato‐Márquez, Vincenzo Torraca and Serge Mostowy 2023. Septins promote caspase activity and coordinate mitochondrial apoptosis. Cytoskeleton. 80 (7/8), pp. 254-265. https://doi.org/10.1002/cm.21696

The effects of gradual vs. rapid weight loss on serum concentrations of myokines and body composition in overweight and obese females

Journal article

Bagheri, Reza, Ashtary-Larky, Damoon, Elliott, B., Willoughby, Darryn S., Kargarfard, Mehdi, Alipour, Meysam, Lamuchi-Deli, Nasrin, Kooti, Wesam, Asbaghi, Omid and Wong, Alexei 2023. The effects of gradual vs. rapid weight loss on serum concentrations of myokines and body composition in overweight and obese females. Archives of Physiology and Biochemistry. 129 (3), pp. 821-828. https://doi.org/10.1080/13813455.2021.1874020

Free School Meals impact

Digital or visual media

Keith, R. 2022. Free School Meals impact . BBC London radio

A correlational analysis of COVID-19 incidence and mortality and urban determinants of vitamin D status across the London boroughs

Journal article

Borna, M., Woloshynowych, M., Schiano-Phan, R., Volpi, E. and Usman, M. 2022. A correlational analysis of COVID-19 incidence and mortality and urban determinants of vitamin D status across the London boroughs. Scientific Reports. 12 (1) 11741. https://doi.org/10.1038/s41598-022-15664-y

Artemisinin inhibits neutrophil and macrophage chemotaxis, cytokine production and NET release

Journal article

Morad, H.O.J., Luqman, S., Garcia Pinto, L., Cunningham, K., Vilar, B., Clayton, G., Shankar-Hari, M. and McNaughton, P.A. 2022. Artemisinin inhibits neutrophil and macrophage chemotaxis, cytokine production and NET release. Scientific Reports. 2022 (12) 11078. https://doi.org/10.1038/s41598-022-15214-6

Succeeding In Science With Neurodiversity

Edited issue

Mattin, L.R. 2022. Succeeding In Science With Neurodiversity. The Endocrinologist. 145 (Autumn), p. 14.

Repurposing the antimalarial compound artemisinin as a novel therapy for inflammatory conditions

Conference item

Morad, H. 2022. Repurposing the antimalarial compound artemisinin as a novel therapy for inflammatory conditions. Drug Repurposing II. Woburn House, London, UK 10 - 11 May 2022 The Biochemical Society.

Trypan Blue Exclusion Assay, Neutral Red, Acridine Orange and Propidium Iodide

Book chapter

Arinzechukwu Ude, Kaiyven Afi-Leslie, Kelechi Okeke and Emmanuel Ogbodo 2022. Trypan Blue Exclusion Assay, Neutral Red, Acridine Orange and Propidium Iodide. in: Cytotoxicity: Understanding Cellular Damage and Response IntechOpen.

Stromal Cells and Extracellular Vesicles

Book chapter

Arinzechukwu Ude, Emmanuel Ogbodo and Kelechi Okeke 2022. Stromal Cells and Extracellular Vesicles. in: Yusuf Tutar and Lütfi Tutar (ed.) Cancer Metastasis: Molecular Mechanism and Clinical Therapy IntechOpen.

Leukaemia: The Purinergic System and Small Extracellular Vesicles

Book chapter

Arinzechukwu Ude and Kelechi Okeke 2022. Leukaemia: The Purinergic System and Small Extracellular Vesicles. in: Margarete Dulce Bagatini (ed.) Purinergic System IntechOpen.

Aprepitant is a novel, selective activator of the K2P channel TRAAK

Journal article

McCoull, D., Veall, E.L., Walsh, Y., Byrom, L., Avkiran, T., Large, J.M., Vaitone, E., Gaffey, F., Jerman, J., Mathie, A. and Wright, P.D. 2022. Aprepitant is a novel, selective activator of the K2P channel TRAAK. Biochemical and Biophysical Research Communications. 588, pp. 41-46. https://doi.org/10.1016/j.bbrc.2021.12.031

Gain and loss of TASK3 channel function and its regulation by novel variation cause KCNK9 imprinting syndrome

Journal article

Cousin, M.A., Veale, E.L., Dsouza, N.R., Tripathi, S., Holden, R.G., Arelin, M., Beek, G., Bekheirnia, M.R., Beygo, J., Bhambhani, V., Bialer, M., Bigoni, S., Boelman, C., Klee, E.W. and Mathie, A. 2022. Gain and loss of TASK3 channel function and its regulation by novel variation cause KCNK9 imprinting syndrome. Genome Medicine. 14 62. https://doi.org/10.1186/s13073-022-01064-4

A KCNB1 gain of function variant causes developmental delay and speech apraxia but not seizures

Journal article

Veale, E.L., Golluscio, A., Grand, K., Graham, J.M. Jr and Mathie, A. 2022. A KCNB1 gain of function variant causes developmental delay and speech apraxia but not seizures. Frontiers in Pharmacology. 13 1093313. https://doi.org/10.3389/fphar.2022.1093313

HIV and Schistosoma Co-Exposure Leads to Exacerbated Pulmonary Endothelial Remodeling and Dysfunction Associated with Altered Cytokine Landscape

Journal article

Sandra Medrano-Garcia, Daniel Morales-Cano, Bianca Barreira, Alba Vera-Zambrano, Rahul Kumar, Djuro Kosanovic, Ralph Theo Schermuly, Brian B. Graham, Francisco Perez-Vizcaino, Alistair Mathie, Rajkumar Savai, Soni Pullamseti, Ghazwan Butrous, Edgar Fernández-Malavé and Angel Cogolludo 2022. HIV and Schistosoma Co-Exposure Leads to Exacerbated Pulmonary Endothelial Remodeling and Dysfunction Associated with Altered Cytokine Landscape. Cells. 11 (15) 2414. https://doi.org/10.3390/cells11152414

Genetic and environmental determinants of diastolic heart function

Journal article

Marjola Thanaj, Johanna Mielke, Kathryn A. McGurk, Wenjia Bai, Nicolò Savioli, Antonio de Marvao, Hannah V. Meyer, Lingyao Zeng, Florian Sohler, R. Thomas Lumbers, Martin R. Wilkins, James S. Ware, Christian Bender, Daniel Rueckert, Aidan MacNamara, Daniel F. Freitag and Declan P. O’Regan 2022. Genetic and environmental determinants of diastolic heart function. Nature Cardiovascular Research. 1, pp. 361-371. https://doi.org/10.1038/s44161-022-00048-2

Chapter 12 - Fermented plant-based beverage: kombucha

Book chapter

Zubaidah, E., Srianta, I and Tewfik, I. 2022. Chapter 12 - Fermented plant-based beverage: kombucha. in: Prakash, Sangeeta, Bhandari, Bhesh R. and Gaiani, Claire (ed.) Engineering Plant-Based Food Systems Elsevier. pp. 215-231

Tailored Dietary Plan to Sustain Healthy Lifestyle of Adults with Restrained Mobility

Journal article

Khawandanah, J., Khawandanah, D., Tewfik, S. and Tewfik, I. 2022. Tailored Dietary Plan to Sustain Healthy Lifestyle of Adults with Restrained Mobility. Food Science & Nutrition Technology. 7 (2). https://doi.org/10.23880/fsnt-16000286

The effect of different concentration of banana ambon puree on the physicochemical, microbiological, and organoleptic properties of rice bran yogurt

Conference paper

Iswanto, N., Srianta, I., Poernomo, L.N., Nugerahani, I., Kuswardhani, I., Ristiarini, S. and Tewfik, I. 2022. The effect of different concentration of banana ambon puree on the physicochemical, microbiological, and organoleptic properties of rice bran yogurt. International Food Conference 2021. Online 03 Nov 2021 E3S Web of Conferences. https://doi.org/10.1051/e3sconf/202234403001

Enhancement of the lactic acid bacteria population, chemical and organoleptic properties of soygurt with nutraceuticals from purple sweet potato (Ipomoea batatas L) paste

Conference paper

Lambertus, E., Srianta, I., Liem, D., Wanaputra, F., Nugerahani, I., Kuswardhani, I. and Tewfik, I. 2022. Enhancement of the lactic acid bacteria population, chemical and organoleptic properties of soygurt with nutraceuticals from purple sweet potato (Ipomoea batatas L) paste. International Food Conference 2021. Online 03 Nov 2021 E3S Web of Conferences. https://doi.org/10.1051/e3sconf/202234402004

Optimization of Physicochemical and Organoleptic Properties of Cookies made of Modified Cassava Flour and Mung Bean Flour

Conference paper

Leticia, C.G., Trisnawati, C.Y., Widyastuti, T.E.W., Srianta, I. and Tewfik, I. 2022. Optimization of Physicochemical and Organoleptic Properties of Cookies made of Modified Cassava Flour and Mung Bean Flour. International Food Conference 2021. Online 03 Nov 2021 E3S Web of Conferences. https://doi.org/10.1051/e3sconf/202234404003

Effect of Molasses Concentration on the Pigment Production of Monascus purpureus M9 on Monascus Fermented Durian Seed

Conference paper

Alvin, A., Nugerahani, I., Ristiarini, S., Kuswardani, I., Srianta, I. and Tewfik, I. 2022. Effect of Molasses Concentration on the Pigment Production of Monascus purpureus M9 on Monascus Fermented Durian Seed. International Food Conference 2021. Online 03 Nov 2021 E3S Web of Conferences. https://doi.org/10.1051/e3sconf/202234403003

The Anti-neoplastic Effects of Probiotics and Prebiotics against Colorectal Cancer: A Systematic Review

Journal article

Cubillos, S.I. and Tewfik, I. 2022. The Anti-neoplastic Effects of Probiotics and Prebiotics against Colorectal Cancer: A Systematic Review. Journal of Food Research. 11 (2). https://doi.org/10.5539/jfr.v11n2p35

Knowledge, attitude and practice of pharmacovigilance among Nepalese health professionals

Journal article

Shrestha, S.C., Ghebremeskel, K., White, K., Minelli, C., Tewfik, I., Thapa, P. and Tewfik, S. 2022. Knowledge, attitude and practice of pharmacovigilance among Nepalese health professionals. Journal of Pharmacovigilance and Drug Research. 3 (3), pp. 40-. https://doi.org/10.53411/jpadr.2022.3.3.07

Severe Acute Respiratory Syndrome Type 2‐Causing Coronavirus: Variants and Preventive Strategies

Journal article

Mehmet Onur Aydogdu, Jennifer L. Rohn, Nazila V. Jafari, Francis Brako, Shervanthi Homer‐Vanniasinkam and Mohan Edirisinghe 2022. Severe Acute Respiratory Syndrome Type 2‐Causing Coronavirus: Variants and Preventive Strategies. Advanced Science. 9 (11) 2104495. https://doi.org/10.1002/advs.202104495

Effect of old age on the subpopulations of enteric glial cells in human descending colon

Conference poster

Baidoo, N. 2022. Effect of old age on the subpopulations of enteric glial cells in human descending colon. 30th United European Gastroenterology Week 2022. Messe Wien Exhibition & Congress Center, Vienna, Austria 08 - 11 Oct 2022 https://doi.org/10.1002/ueg2.12294

Total collagen content and distribution is increased in human colon during advancing age

Conference poster

Baidoo, N. 2022. Total collagen content and distribution is increased in human colon during advancing age. 29th International Student Congress Of (bio)Medical Sciences. University Medical Center Groningen, Groningen, The Netherlands 08 - 10 Jun 2022

The vulnerability of the human taenia coli to alterations in total collagen within the colon of the elderly

Journal article

Baidoo, N., Sanger, G.J. and Belai, A. 2022. The vulnerability of the human taenia coli to alterations in total collagen within the colon of the elderly. Acta Histochemica. 124 (8) 151958. https://doi.org/10.1016/j.acthis.2022.151958

Total collagen content and distribution is increased in human colon during advancing age

Journal article

Nicholas Baidoo, Ellie Crawley, Charles H. Knowles, Gareth J. Sanger and Abi Belai 2022. Total collagen content and distribution is increased in human colon during advancing age. PLoS ONE. 17 (6) e0269689. https://doi.org/10.1371/journal.pone.0269689

The urothelium: a multi-faceted barrier against a harsh environment

Journal article

Nazila V. Jafari and Jennifer L. Rohn 2022. The urothelium: a multi-faceted barrier against a harsh environment. Mucosal Immunology. 15 (6), pp. 1127-1142. https://doi.org/10.1038/s41385-022-00565-0

Endogenous versus exogenous cell replacement for Parkinson’s disease: where are we at and where are we going?

Journal article

Theodora Mourtzi and Ilias Kazanis 2022. Endogenous versus exogenous cell replacement for Parkinson’s disease: where are we at and where are we going? Neural Regeneration Research. 17 (12), pp. 2637-2642. https://doi.org/10.4103/1673-5374.336137

Heterogeneity of quiescent and active neural stem cells in the postnatal brain

Journal article

Dimitrios Dimitrakopoulos, Dimitrios Kakogiannis and Ilias Kazanis 2022. Heterogeneity of quiescent and active neural stem cells in the postnatal brain. The International Journal of Developmental Biology. 66 (1-2-3), pp. 51-58. https://doi.org/10.1387/ijdb.220010ik

Divergence between Neuronal and Oligodendroglial Cell Fate, in Postnatal Brain Neural Stem Cells, Leads to Divergent Properties in Polymorphic In Vitro Assays

Journal article

Maria Anesti, Stavroula Magkafa, Efstathia Prantikou and Ilias Kazanis 2022. Divergence between Neuronal and Oligodendroglial Cell Fate, in Postnatal Brain Neural Stem Cells, Leads to Divergent Properties in Polymorphic In Vitro Assays. Cells. 11 (11) 1743. https://doi.org/10.3390/cells11111743

The Digital Health Evidence Generator

Project report

Bolotov, A., Volpi, E. and Chan You Fee, D. 2022. The Digital Health Evidence Generator. University of Westminster. https://doi.org/10.34737/w6866


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